MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1AXM	3.0	HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
1DJS	2.4	LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1
1DZC		High resolution structure of acidic fibroblast growth factor. Mutant FGF-4-ALA-(24-154), 24 NMR structures
1DZD		High resolution structure of acidic fibroblast growth factor (27-154), 24 NMR structures
1E0O	2.8	CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
1EVT	2.8	CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
1HKN	2.0	A complex between acidic fibroblast growth factor and 5-amino-2-naphthalenesulfonate
1JQZ	1.65	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag.
1JT3	1.95	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Histidine Tag AND LEU 73 REPLACED BY VAL (L73V)
1JT4	1.78	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND VAL 109 REPLACED BY LEU (V109L)
1JT5	1.85	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L73V/V109L)
1JT7	1.7	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE AND LEU 73 REPLACED BY VAL AND VAL 109 REPLACED BY LEU (L44F/L73V/V109L)
1JTC	1.7	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag AND LEU 44 REPLACED BY PHE (L44F)
1JY0	1.7	Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V).
1K5U	2.0	Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with His93 replaced by Gly (H93G).
1K5V	2.1	Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag with Asn106 replaced by Gly (N106G).
1M16	1.7	Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Terminal His Tag and Leu 44 Replaced with Phe (L44F), Leu 73 Replaced with Val (L73V), Val 109 Replaced with Leu (V109L) and Cys 117 Replaced with Val (C117V).
1NZK	1.95	Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor
1P63	1.6	Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag and Leu111 Replaced with Ile (L111I)
1PZZ	2.0	Crystal structure of FGF-1, V51N mutant
1Q03	2.05	Crystal structure of FGF-1, S50G/V51G mutant
1Q04	1.8	Crystal structure of FGF-1, S50E/V51N
1RG8	1.1	Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form)
1RML		NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES
1RY7	3.2	Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
1YTO	2.1	Crystal Structure of Gly19 deletion Mutant of Human Acidic Fibroblast Growth Factor
1Z2V	1.9	Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor
1Z4S	2.6	Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth Factor
2AFG	2.0	2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
2AQZ	1.85	Crystal structure of FGF-1, S17T/N18T/G19 deletion mutant
2AXM	3.0	HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
2ERM		Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue
2HW9	1.6	Crystal structure of Lys12Cys/Cys117Val mutant of human acidic fibroblast Growth factor at 1.60 angstrom resolution.
2HWA	1.65	Crystal structure of Lys12Thr/Cys117Val mutant of human acidic fibroblast growth factor at 1.65 angstrom resolution.
2HWM	1.6	Crystal structure of Lys12Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.60 angstrom resolution
2HZ9	1.7	Crystal structure of Lys12Val/Asn95Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.70 angstrom resolution.
2K43		Acidic fibroblast growth factor solution structure in the FGF-1-C2A binary complex: key component in the fibroblast growthfactor non-classical pathway
2K4A		FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway
2K8R		Solution structure of human acidic fibroblast growth factor in complex with anti-angiogenic drug inositol hexaphosphate (IP6)
2KI4		FGF1-S100A13 complex structure: key component in non-classical path way of FGF1
2KI6		The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion
2NTD	2.52	Human fibroblast growth factor-1 (140 amino acid form) with Cys117Val/Pro134Cys mutations
2Q9X	1.7	Crystal structure of highly stable mutant Q40P/S47I/H93G of human fibroblast growth factor-1
2RQ9		Solution structure of human acidic fibroblast growth factor (aFGF) in the presence of a protein stabilizer NDSB-new
3B9U	1.55	Crystal structure of L26N/D28N/H93G mutant of Human acidic fibroblast growth factor
3BA4	1.8	Crystal structure of L26D mutant of Human acidic fibroblast growth factor
3BA5	1.75	Crystal structure of D28A mutant of Human acidic fibroblast growth factor
3BA7	1.6	Crystal structure of L26N/D28A mutant of Human acidic fibroblast growth factor
3BAD	2.0	Crystal structure of D70A/H93G mutant of Human acidic fibroblast growth factor
3BAG	1.75	Crystal structure of K112N/N114A mutant of Human acidic fibroblast growth factor
3BAH	1.65	Crystal structure of K112N mutant of Human acidic fibroblast growth factor
3BAO	1.55	Crystal structure of L26N mutant of Human acidic fibroblast growth factor
3BAQ	1.8	Crystal structure of L26A mutant of Human acidic fibroblast growth factor
3BAU	1.6	Crystal structure of K12V/L26D/D28A mutant of Human acidic fibroblast growth factor
3BAV	1.62	Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor
3BB2	1.5	Crystal structure of L26D/D28N mutant of Human acidic fibroblast growth factor
3CQA	1.8	Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala and Lys101Ala
3CRG	1.85	Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala
3CRH	2.15	Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala
3CRI	2.1	Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser, Glu82Asn and Lys101Ala
3CU1	2.6	Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex
3FGM	1.95	Crystal structure of L44F/C83T/C117V/F132W mutant of Human acidic fibroblast growth factor
3FJ8	2.0	Crystal structure of C117I mutant of Human acidic fibroblast growth factor
3FJ9	1.9	Crystal structure of F85W mutant of Human acidic fibroblast growth factor
3FJA	1.95	Crystal structure of F132W mutant of Human acidic fibroblast growth factor
3FJB	2.0	Crystal structure of V31I mutant of Human acidic fibroblast growth factor
3FJC	2.0	Crystal structure of L44W mutant of Human acidic fibroblast growth factor
3FJD	1.9	Crystal structure of L44F/F132W mutant of Human acidic fibroblast growth factor
3FJE	2.1	Crystal structure of C83S mutant of Human acidic fibroblast growth factor
3FJF	1.9	Crystal structure of C83T mutant of Human acidic fibroblast growth factor
3FJH	1.9	Crystal structure of C83A mutant of Human acidic fibroblast growth factor
3FJI	2.55	Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor
3FJJ	1.9	Crystal structure of C83V mutant of Human acidic fibroblast growth factor
3FJK	2.15	Crystal structure of A66C mutant of Human acidic fibroblast growth factor
3HOM	2.3	Crystal structure of oxidized A66C mutant of Human acidic fibroblast growth factor
3JUT	2.25	Acidic Fibroblast Growth Factor (FGF-1) complexed with gentisic acid
3K1X	1.98	Acidic Fibroblast Growth Factor (FGF-1) complexed with dobesilate
3O3Q	1.6	Crystal structure of L44F/M67I/L73V/A103G/deletion 104-106/F108Y/V109L/L111I/C117V/R119G/deletion 120-122 mutant form of Human acidic fibroblast growth factor
3OJ2	2.2	Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation
3OJM	2.1	Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation
3OJV	2.6	Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop
3UD7	2.8	Crystal Structure Analysis of FGF1-Disaccharide(NI21) complexes
3UD8	2.37	Crystal Structure Analysis of FGF1-Disaccharide(NI22) complex
3UD9	2.34	Crystal Structure Analysis of FGF1-Disaccharide(NI23) complex
3UDA	2.51	Crystal Structure Analysis of FGF1-Disaccharide(NI24) complex
4J23	3.882	Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex
4Q91	1.799	Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
4Q9G	1.554	Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor
4Q9P	1.8	Crystal structure of C16T/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
4QAL	1.5	Crystal structure of C117A mutant of human acidic fibroblast growth factor
4QBC	1.519	Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium formate buffer
4QBV	1.497	Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer
4QC4	1.491	Crystal structure of C117S mutant of human acidic fibroblast growth factor
4QO3	2.047	Crystal structure of C16S/N18S/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
4XKI	2.0	Human Fibroblast Growth Factor - 1 (FGF-1) mutant S116R
4YOL	1.97	Human fibroblast growth factor-1 C16S/A66C/C117A/P134A

GO term

GO ontology	GO term	GO description
Biological Process	GO:0032148	activation of protein kinase B activity
Biological Process	GO:0009653	anatomical structure morphogenesis
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0009887	animal organ morphogenesis
Biological Process	GO:0060681	branch elongation involved in ureteric bud branching
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0034605	cellular response to heat
Biological Process	GO:0050673	epithelial cell proliferation
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway
Biological Process	GO:0030324	lung development
Biological Process	GO:0072163	mesonephric epithelium development
Biological Process	GO:0001759	organ induction
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0043406	positive regulation of MAP kinase activity
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0051781	positive regulation of cell division
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process
Biological Process	GO:0010595	positive regulation of endothelial cell migration
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation
Biological Process	GO:1902533	positive regulation of intracellular signal transduction
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0030334	regulation of cell migration
Biological Process	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor
Biological Process	GO:1901509	regulation of endothelial tube morphogenesis
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0042060	wound healing
Molecular Function	GO:0030544	Hsp70 protein binding
Molecular Function	GO:0044548	S100 protein binding
Molecular Function	GO:0005104	fibroblast growth factor receptor binding
Molecular Function	GO:0008083	growth factor activity
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0005178	integrin binding
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm

InterPro / Pfam

InterPro	InterPro name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF

Pfam	Pfam name
PF00167	Fibroblast growth factor

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-109704	PI3K Cascade	Internal node	R-HSA-162582	Signal Transduction
R-HSA-1257604	PIP3 activates AKT signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-1839122	Signaling by activated point mutants of FGFR1	Leaf	R-HSA-1643685	Disease
R-HSA-1839130	Signaling by activated point mutants of FGFR3	Leaf	R-HSA-1643685	Disease
R-HSA-190322	FGFR4 ligand binding and activation	Internal node	R-HSA-162582	Signal Transduction
R-HSA-190370	FGFR1b ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190371	FGFR3b ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190372	FGFR3c ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190373	FGFR1c ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190375	FGFR2c ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190377	FGFR2b ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2033519	Activated point mutants of FGFR2	Leaf	R-HSA-1643685	Disease
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	Leaf	R-HSA-1643685	Disease
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654687	Downstream signaling of activated FGFR1	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654688	SHC-mediated cascade:FGFR1	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654689	PI-3K cascade:FGFR1	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654693	FRS-mediated FGFR1 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654695	PI-3K cascade:FGFR2	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654699	SHC-mediated cascade:FGFR2	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654700	FRS-mediated FGFR2 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654704	SHC-mediated cascade:FGFR3	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654706	FRS-mediated FGFR3 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654710	PI-3K cascade:FGFR3	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654712	FRS-mediated FGFR4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654719	SHC-mediated cascade:FGFR4	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654720	PI-3K cascade:FGFR4	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654726	Negative regulation of FGFR1 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654727	Negative regulation of FGFR2 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654732	Negative regulation of FGFR3 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654733	Negative regulation of FGFR4 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5655253	Signaling by FGFR2 in disease	Internal node	R-HSA-1643685	Disease
R-HSA-5655302	Signaling by FGFR1 in disease	Internal node	R-HSA-1643685	Disease
R-HSA-5655332	Signaling by FGFR3 in disease	Internal node	R-HSA-1643685	Disease
R-HSA-5673001	RAF/MAP kinase cascade	Internal node	R-HSA-162582	Signal Transduction
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8851708	Signaling by FGFR2 IIIa TM	Leaf	R-HSA-1643685	Disease

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
breast	adipocytes	Low	Enhanced
breast	glandular cells	Low	Enhanced
breast	myoepithelial cells	Low	Enhanced
kidney	cells in glomeruli	High	Enhanced

Disease

Location	ECO term	Pubmed
Cytoplasm
Cytoplasm, cell cortex
Cytoplasm, cytosol
Nucleus
Secreted

Summary of P05230

Gene: FGF1, FGFA
Protein: Fibroblast growth factor 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P05230

Gene: FGF1, FGFA Protein: Fibroblast growth factor 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: FGF1, FGFA
Protein: Fibroblast growth factor 1