MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1A02	2.7	STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
1FOS	3.05	TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES
1JNM	2.2	Crystal Structure of the Jun/CRE Complex
1JUN		NMR STUDY OF C-JUN HOMODIMER
1S9K	3.1	Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site
1T2K	3.0	Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
5FV8	1.99	Structure of cJun-FosW coiled coil complex.
5T01	1.89	Human c-Jun DNA binding domain homodimer in complex with methylated DNA
6Y3V	1.499	14-3-3 Sigma in complex with phosphorylated c-Jun peptide

GO term

GO ontology	GO term	GO description
Biological Process	GO:0060395	SMAD protein signal transduction
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0031103	axon regeneration
Biological Process	GO:0008283	cell population proliferation
Biological Process	GO:0072740	cellular response to anisomycin
Biological Process	GO:0071276	cellular response to cadmium ion
Biological Process	GO:0071277	cellular response to calcium ion
Biological Process	GO:0034614	cellular response to reactive oxygen species
Biological Process	GO:0061029	eyelid development in camera-type eye
Biological Process	GO:0140467	integrated stress response signaling
Biological Process	GO:0035026	leading edge cell differentiation
Biological Process	GO:0001889	liver development
Biological Process	GO:0001774	microglial cell activation
Biological Process	GO:0030224	monocyte differentiation
Biological Process	GO:0043922	negative regulation by host of viral transcription
Biological Process	GO:0043392	negative regulation of DNA binding
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:0031953	negative regulation of protein autophosphorylation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Biological Process	GO:0003151	outflow tract morphogenesis
Biological Process	GO:0043923	positive regulation by host of viral transcription
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:2000144	positive regulation of DNA-templated transcription initiation
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation
Biological Process	GO:0010634	positive regulation of epithelial cell migration
Biological Process	GO:0048146	positive regulation of fibroblast proliferation
Biological Process	GO:1902895	positive regulation of miRNA transcription
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0035994	response to muscle stretch
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0070412	R-SMAD binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0035497	cAMP response element binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0140296	general transcription initiation factor binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding
Molecular Function	GO:0000976	transcription cis-regulatory region binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0000791	euchromatin
Cellular Component	GO:0000228	nuclear chromosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0035976	transcription factor AP-1 complex
Cellular Component	GO:0005667	transcription regulator complex
Cellular Component	GO:0017053	transcription repressor complex

InterPro / Pfam

InterPro	InterPro name
IPR002112	Transcription factor Jun
IPR004827	Basic-leucine zipper domain
IPR005643	Jun-like transcription factor
IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily
IPR046347	Basic-leucine zipper domain superfamily

Pfam	Pfam name
PF00170	bZIP transcription factor
PF03957	Jun-like transcription factor

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1912408	Pre-NOTCH Transcription and Translation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2559580	Oxidative Stress Induced Senescence	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-2871796	FCERI mediated MAPK activation	Leaf	R-HSA-168256	Immune System
R-HSA-450341	Activation of the AP-1 family of transcription factors	Leaf	R-HSA-168256	Immune System
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-5687128	MAPK6/MAPK4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Leaf	R-HSA-1643685	Disease
R-HSA-8943724	Regulation of PTEN gene transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9018519	Estrogen-dependent gene expression	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9673324	WNT5:FZD7-mediated leishmania damping	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Nucleus

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Enhanced
appendix	glandular cells	Medium	Enhanced
breast	adipocytes	Low	Enhanced
breast	glandular cells	Medium	Enhanced
cerebellum	granular cells - nucleus	High	Enhanced
cerebellum	white matter cells - nucleus	Medium	Enhanced
cerebral cortex	neuronal cells	Low	Enhanced
cervix	squamous epithelial cells	Medium	Enhanced
colon	endothelial cells	Low	Enhanced
colon	glandular cells	Medium	Enhanced
colon	peripheral nerve/ganglion	Medium	Enhanced
duodenum	glandular cells	Medium	Enhanced
endometrium 1	cells in endometrial stroma	Low	Enhanced
endometrium 2	cells in endometrial stroma	Low	Enhanced
endometrium 2	glandular cells	Low	Enhanced
epididymis	glandular cells	Low	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
fallopian tube	ciliated cells (cell body)	Medium	Enhanced
fallopian tube	non-ciliated cells	Medium	Enhanced
gallbladder	glandular cells	High	Enhanced
kidney	distal tubules	High	Enhanced
kidney	proximal tubules (cell body)	Medium	Enhanced
lung	alveolar cells type I	Medium	Enhanced
lung	alveolar cells type II	Low	Enhanced
lung	macrophages	Medium	Enhanced
nasopharynx	basal cells	Medium	Enhanced
nasopharynx	ciliated cells (cell body)	Medium	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
placenta	endothelial cells	Low	Enhanced
rectum	glandular cells	Medium	Enhanced
salivary gland	glandular cells	Low	Enhanced
skin 1	cells in basal layer	Low	Enhanced
skin 1	cells in granular layer	Medium	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 1	fibrohistiocytic cells	High	Enhanced
skin 2	cells in basal layer	High	Enhanced
skin 2	cells in granular layer	Medium	Enhanced
skin 2	cells in spinous layer	Low	Enhanced
skin 2	endothelial cells	Medium	Enhanced
skin 2	fibrohistiocytic cells	High	Enhanced
small intestine	glandular cells	Medium	Enhanced
smooth muscle	smooth muscle cells	Low	Enhanced
stomach 1	glandular cells	Medium	Enhanced
stomach 2	glandular cells	Medium	Enhanced
thyroid gland	glandular cells	High	Enhanced
urinary bladder	urothelial cells	Medium	Enhanced
vagina	squamous epithelial cells	High	Enhanced

Summary of P05412

Gene: JUN
Protein: Transcription factor Jun

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P05412

Gene: JUN Protein: Transcription factor Jun

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: JUN
Protein: Transcription factor Jun