Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1OWX | Solution structure of the C-terminal RRM of human La (La225-334) | |
1S79 | Solution structure of the central RRM of human La protein | |
1S7A | NMR structure of the La motif of human La protein | |
1YTY | 2.29 | Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen |
1ZH5 | 1.85 | Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen |
2VOD | 2.1 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU |
2VON | 2.1 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU |
2VOO | 1.8 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU |
2VOP | 2.8 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0075522 | IRES-dependent viral translational initiation |
Biological Process | GO:0008334 | histone mRNA metabolic process |
Biological Process | GO:0071045 | nuclear histone mRNA catabolic process |
Biological Process | GO:0045727 | positive regulation of translation |
Biological Process | GO:1903608 | protein localization to cytoplasmic stress granule |
Biological Process | GO:0042780 | tRNA 3'-end processing |
Biological Process | GO:0001682 | tRNA 5'-leader removal |
Biological Process | GO:0006409 | tRNA export from nucleus |
Biological Process | GO:0006400 | tRNA modification |
Biological Process | GO:0008033 | tRNA processing |
Molecular Function | GO:0003677 | DNA binding |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0003729 | mRNA binding |
Molecular Function | GO:0008266 | poly(U) RNA binding |
Molecular Function | GO:1990825 | sequence-specific mRNA binding |
Molecular Function | GO:0000049 | tRNA binding |
Cellular Component | GO:0000781 | chromosome, telomeric region |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0010494 | cytoplasmic stress granule |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:1990904 | ribonucleoprotein complex |
InterPro | InterPro name |
---|---|
IPR000504 | RNA recognition motif domain |
IPR002344 | Lupus La protein |
IPR006630 | La-type HTH domain |
IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
IPR014886 | La protein, xRRM domain |
IPR035979 | RNA-binding domain superfamily |
IPR036388 | Winged helix-like DNA-binding domain superfamily |
IPR036390 | Winged helix DNA-binding domain superfamily |
IPR045180 | La domain containing protein |
Pfam | Pfam name |
---|---|
PF00076 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
PF05383 | La domain |
PF08777 | RNA binding motif |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-73980 | RNA Polymerase III Transcription Termination | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
Location | ECO term | Pubmed |
---|---|---|
Nucleus | ECO:0000305 |