Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1OWX | Solution structure of the C-terminal RRM of human La (La225-334) | |
| 1S79 | Solution structure of the central RRM of human La protein | |
| 1S7A | NMR structure of the La motif of human La protein | |
| 1YTY | 2.29 | Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen |
| 1ZH5 | 1.85 | Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen |
| 2VOD | 2.1 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU |
| 2VON | 2.1 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU |
| 2VOO | 1.8 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU |
| 2VOP | 2.8 | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0075522 | IRES-dependent viral translational initiation |
| Biological Process | GO:0008334 | histone mRNA metabolic process |
| Biological Process | GO:0071045 | nuclear histone mRNA catabolic process |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:1903608 | protein localization to cytoplasmic stress granule |
| Biological Process | GO:0042780 | tRNA 3'-end processing |
| Biological Process | GO:0001682 | tRNA 5'-leader removal |
| Biological Process | GO:0006409 | tRNA export from nucleus |
| Biological Process | GO:0006400 | tRNA modification |
| Biological Process | GO:0008033 | tRNA processing |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0008266 | poly(U) RNA binding |
| Molecular Function | GO:1990825 | sequence-specific mRNA binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| InterPro
|
InterPro name |
|---|---|
| IPR000504 | RNA recognition motif domain |
| IPR002344 | Lupus La protein |
| IPR006630 | La-type HTH domain |
| IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| IPR014886 | La protein, xRRM domain |
| IPR035979 | RNA-binding domain superfamily |
| IPR036388 | Winged helix-like DNA-binding domain superfamily |
| IPR036390 | Winged helix DNA-binding domain superfamily |
| IPR045180 | La domain containing protein |
| Pfam
|
Pfam name |
|---|---|
| PF00076 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
| PF05383 | La domain |
| PF08777 | RNA binding motif |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-73980 | RNA Polymerase III Transcription Termination | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Nucleus | ECO:0000305 |