MultifacetedProtDB - Bologna Biocomputing Group

Summary of P05813

Gene: CRYBA1, CRYB1
Protein: Beta-crystallin A3

Protein family
Protein sequence
Protein function

Catalytic activity

The protein has not catalytic activity

Publications

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0002088	lens development in camera-type eye
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade
Biological Process	GO:0032007	negative regulation of TOR signaling
Biological Process	GO:0001818	negative regulation of cytokine production
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
Biological Process	GO:0051898	negative regulation of protein kinase B signaling
Biological Process	GO:0006909	phagocytosis
Biological Process	GO:2000210	positive regulation of anoikis
Biological Process	GO:0010506	regulation of autophagy
Biological Process	GO:0007601	visual perception
Molecular Function	GO:0005212	structural constituent of eye lens
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
cataract 10 multiple types	MONDO:0010948	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:600881	Orphanet:98985
cataract 10 multiple types	MONDO:0010948	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:600881	Orphanet:98995
early-onset lamellar cataract	MONDO:0018611	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:441452
early-onset sutural cataract	MONDO:0020372	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98985
early-onset nuclear cataract	MONDO:0020376	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98991
early-onset posterior polar cataract	MONDO:0020378	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98993