Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1C0F | 2.4 | CRYSTAL STRUCTURE OF DICTYOSTELIUM CAATP-ACTIN IN COMPLEX WITH GELSOLIN SEGMENT 1 |
| 1C0G | 2.0 | CRYSTAL STRUCTURE OF 1:1 COMPLEX BETWEEN GELSOLIN SEGMENT 1 AND A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 228: Q228K/T229A/A230Y/E360H) |
| 1D4X | 1.75 | Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at 1.75 A resolution. |
| 1DEJ | 2.4 | CRYSTAL STRUCTURE OF A DICTYOSTELIUM/TETRAHYMENA CHIMERA ACTIN (MUTANT 646: Q228K/T229A/A230Y/A231K/S232E/E360H) IN COMPLEX WITH HUMAN GELSOLIN SEGMENT 1 |
| 1EQY | 2.3 | COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1 |
| 1ESV | 2.0 | COMPLEX BETWEEN LATRUNCULIN A:RABBIT MUSCLE ALPHA ACTIN:HUMAN GELSOLIN DOMAIN 1 |
| 1H1V | 2.99 | gelsolin G4-G6/actin complex |
| 1KCQ | 1.65 | Human Gelsolin Domain 2 with a Cd2+ bound |
| 1MDU | 2.2 | Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (GS-1) |
| 1NLV | 1.8 | Crystal Structure Of Dictyostelium Discoideum Actin Complexed With Ca ATP And Human Gelsolin Segment 1 |
| 1NM1 | 1.8 | Crystal Structure of D. Dicsoideum Actin Complexed With Gelsolin Segment 1 and Mg ATP at 1.8 A Resolution |
| 1NMD | 1.9 | Crystal Structure of D. Discoideum Actin-Gelsolin Segment 1 Complex Crystallized In Presence Of Lithium ATP |
| 1P8X | 2.0 | The Calcium-Activated C-terminal half of gelsolin |
| 1P8Z | 2.6 | Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156 |
| 1SOL | A PIP2 AND F-ACTIN-BINDING SITE OF GELSOLIN, RESIDUE 150-169 (NMR, AVERAGED STRUCTURE) | |
| 1T44 | 2.0 | Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation |
| 1YAG | 1.9 | STRUCTURE OF THE YEAST ACTIN-HUMAN GELSOLIN SEGMENT 1 COMPLEX |
| 1YVN | 2.1 | THE YEAST ACTIN VAL 159 ASN MUTANT COMPLEX WITH HUMAN GELSOLIN SEGMENT 1. |
| 2FF3 | 2.0 | Crystal structure of Gelsolin domain 1:N-wasp V2 motif hybrid in complex with actin |
| 2FF6 | 2.05 | Crystal structure of Gelsolin domain 1:ciboulot domain 2 hybrid in complex with actin |
| 2FH1 | 1.55 | C-terminal half of gelsolin soaked in low calcium at pH 4.5 |
| 2FH2 | 2.5 | C-terminal half of gelsolin soaked in EGTA at pH 4.5 |
| 2FH3 | 2.87 | C-terminal half of gelsolin soaked in low calcium at pH 8 |
| 2FH4 | 3.0 | C-terminal half of gelsolin soaked in EGTA at pH 8 |
| 3A5L | 2.4 | Crystal Structure of a Dictyostelium P109A Mg2+-Actin in Complex with Human Gelsolin Segment 1 |
| 3A5M | 2.4 | Crystal Structure of a Dictyostelium P109I Mg2+-Actin in Complex with Human Gelsolin Segment 1 |
| 3A5N | 2.36 | Crystal Structure of a Dictyostelium P109A Ca2+-Actin in Complex with Human Gelsolin Segment 1 |
| 3A5O | 2.4 | Crystal Structure of a Dictyostelium P109I Ca2+-Actin in Complex with Human Gelsolin Segment 1 |
| 3CI5 | 1.7 | Complex of Phosphorylated Dictyostelium Discoideum Actin with Gelsolin |
| 3CIP | 1.6 | Complex of Dictyostelium Discoideum Actin with Gelsolin |
| 3CJB | 3.21 | Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1 |
| 3CJC | 3.9 | Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with DNase I and Gelsolin-segment 1 |
| 3FFK | 3.0 | Crystal structure of human Gelsolin domains G1-G3 bound to Actin |
| 3FFN | 3.0 | Crystal structure of calcium-free human gelsolin |
| 3TU5 | 3.0 | Actin complex with Gelsolin Segment 1 fused to Cobl segment |
| 4PKG | 1.8 | Complex of ATP-actin With the N-terminal Actin-Binding Domain of Tropomodulin |
| 4PKH | 2.15 | Complex of ADP-actin With the N-terminal Actin-Binding Domain of Tropomodulin |
| 4PKI | 2.3 | Complex of ATP-actin With the C-terminal Actin-Binding Domain of Tropomodulin |
| 4S10 | 2.614 | Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis |
| 4Z94 | 2.4 | Actin Complex With a Chimera of Tropomodulin-1 and Leiomodin-1 Actin-Binding Site 2 |
| 5FAE | 1.7 | N184K pathological variant of gelsolin domain 2 (trigonal form) |
| 5FAF | 1.05 | N184K pathological variant of gelsolin domain 2 (orthorhombic form) |
| 5H3M | Solution structure of human Gelsolin protein domain 1 at pH 5.0 | |
| 5H3N | Solution structure of human Gelsolin protein domain 1 at pH 7.3 | |
| 5O2Z | 1.7 | Domain swap dimer of the G167R variant of gelsolin second domain |
| 5UBO | 2.39 | Mical-oxidized Actin complex with Gelsolin Segment 1 |
| 5ZZ0 | 2.635 | HUMAN GELSOLIN FROM RESIDUES GLU28 TO ARG161 WITH CALCIUM |
| 6H1F | 1.9 | Structure of the nanobody-stabilized gelsolin D187N variant (second domain) |
| 6JCO | 2.88 | Crystal structure of calcium free human gelsolin amyloid mutant D187N |
| 6JEG | 2.975 | Crystal structure of calcium free human gelsolin amyloid mutant G167R |
| 6JEH | 2.95 | Crystal structure of calcium free human gelsolin amyloid mutant D187Y |
| 6LJE | 1.4 | Crystal structure of gelsolin G3 domain (calcium and magnesium condition) |
| 6LJF | 1.5 | Crystal structure of gelsolin G3 domain (calcium condition) |
| 6Q9R | 2.73 | Crystal structure of the pathological N184K variant of calcium-free human gelsolin |
| 6Q9Z | 3.8 | Crystal structure of the pathological G167R variant of calcium-free human gelsolin, |
| 6QBF | 3.499 | Crystal structure of the pathological D187N variant of calcium-free human gelsolin. |
| 6QW3 | 1.3 | Calcium-bound gelsolin domain 2 |
| 7P2B | 3.0 | Crystal structure of human gelsolin amyloid mutant A551P |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0051693 | actin filament capping |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0008154 | actin polymerization or depolymerization |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:0086003 | cardiac muscle cell contraction |
| Biological Process | GO:0030031 | cell projection assembly |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0097284 | hepatocyte apoptotic process |
| Biological Process | GO:0046597 | negative regulation of viral entry into host cell |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0051127 | positive regulation of actin nucleation |
| Biological Process | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1902174 | positive regulation of keratinocyte apoptotic process |
| Biological Process | GO:1903923 | positive regulation of protein processing in phagocytic vesicle |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:1903903 | regulation of establishment of T cell polarity |
| Biological Process | GO:1903906 | regulation of plasma membrane raft polarization |
| Biological Process | GO:0071801 | regulation of podosome assembly |
| Biological Process | GO:1903909 | regulation of receptor clustering |
| Biological Process | GO:0055119 | relaxation of cardiac muscle |
| Biological Process | GO:0097017 | renal protein absorption |
| Biological Process | GO:0035994 | response to muscle stretch |
| Biological Process | GO:0042989 | sequestering of actin monomers |
| Biological Process | GO:0014891 | striated muscle atrophy |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0045159 | myosin II binding |
| Molecular Function | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Cellular Component | GO:0030478 | actin cap |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0072562 | blood microparticle |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0045335 | phagocytic vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0016528 | sarcoplasm |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins | Leaf | R-HSA-5357801 | Programmed Cell Death |
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-9662361 | Sensory processing of sound by outer hair cells of the cochlea | Internal node | R-HSA-9709957 | Sensory Perception |
| R-HSA-977225 | Amyloid fiber formation | Leaf | R-HSA-392499 | Metabolism of proteins |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000083 | Renal insufficiency |
| HP:0000093 | Proteinuria |
| HP:0000100 | Nephrotic syndrome |
| HP:0000217 | Xerostomia |
| HP:0000365 | Hearing impairment |
| HP:0000478 | Abnormality of the eye |
| HP:0000501 | Glaucoma |
| HP:0000505 | Visual impairment |
| HP:0000518 | Cataract |
| HP:0000707 | Abnormality of the nervous system |
| HP:0000716 | Depression |
| HP:0000958 | Dry skin |
| HP:0000969 | Edema |
| HP:0000973 | Cutis laxa |
| HP:0000978 | Bruising susceptibility |
| HP:0000989 | Pruritus |
| HP:0001005 | Dermatological manifestations of systemic disorders |
| HP:0001097 | Keratoconjunctivitis sicca |
| HP:0001149 | Lattice corneal dystrophy |
| HP:0001251 | Ataxia |
| HP:0001260 | Dysarthria |
| HP:0001271 | Polyneuropathy |
| HP:0001283 | Bulbar palsy |
| HP:0001438 | Abnormal abdomen morphology |
| HP:0001488 | Bilateral ptosis |
| HP:0001638 | Cardiomyopathy |
| HP:0002411 | Myokymia |
| HP:0002483 | Bulbar signs |
| HP:0002549 | Deficit in phonologic short-term memory |
| HP:0003216 | Generalized amyloid deposition |
| HP:0003581 | Adult onset |
| HP:0003774 | Stage 5 chronic kidney disease |
| HP:0004926 | Orthostatic hypotension due to autonomic dysfunction |
| HP:0007067 | Distal peripheral sensory neuropathy |
| HP:0007488 | Diffuse skin atrophy |
| HP:0008070 | Sparse hair |
| HP:0008404 | Nail dystrophy |
| HP:0010535 | Sleep apnea |
| HP:0010628 | Facial palsy |
| HP:0010749 | Blepharochalasis |
| HP:0011356 | Regional abnormality of skin |
| HP:0011675 | Arrhythmia |
| HP:0011947 | Respiratory tract infection |
| HP:0012185 | Constrictive median neuropathy |
| HP:0012332 | Abnormal autonomic nervous system physiology |
| HP:0012473 | Tongue atrophy |
| HP:0012804 | Corneal ulceration |
| HP:0025408 | Abnormal spleen morphology |
| HP:0030843 | Cardiac amyloidosis |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| finnish type amyloidosis | MONDO:0007097 | E85 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:105120 | Orphanet:85448 |