MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.11.22	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; cyclin-dependent kinase
2.7.11.23	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; [RNA-polymerase]-subunit kinase

Structure

PDB	Resolution (Å)	PDB name
4Y72	2.3	Human CDK1/CyclinB1/CKS2 With Inhibitor
4YC3	2.7	CDK1/CyclinB1/CKS2 Apo
4YC6	2.6	CDK1/CKS1
5HQ0	2.3	Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor
5LQF	2.06	CDK1/CyclinB1/CKS2 in complex with NU6102
6GU2	2.0	CDK1/CyclinB/Cks2 in complex with Flavopiridol
6GU3	2.65	CDK1/CyclinB/Cks2 in complex with AZD5438
6GU4	2.73	CDK1/CyclinB/Cks2 in complex with CGP74514A
6GU6	2.33	CDK1/Cks2 in complex with Dinaciclib
6GU7	2.75	CDK1/Cks2 in complex with AZD5438
6TWN	2.28	Crystal structure of Talin1 R7R8 in complex with CDK1 (206-223)
7NJ0	3.6	CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0006260	DNA replication
Biological Process	GO:0070371	ERK1 and ERK2 cascade
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle
Biological Process	GO:0090166	Golgi disassembly
Biological Process	GO:0031100	animal organ regeneration
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0051301	cell division
Biological Process	GO:0016477	cell migration
Biological Process	GO:0070301	cellular response to hydrogen peroxide
Biological Process	GO:0071407	cellular response to organic cyclic compound
Biological Process	GO:0007098	centrosome cycle
Biological Process	GO:0030261	chromosome condensation
Biological Process	GO:0030855	epithelial cell differentiation
Biological Process	GO:0048144	fibroblast proliferation
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:1902850	microtubule cytoskeleton organization involved in mitosis
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:0018105	peptidyl-serine phosphorylation
Biological Process	GO:0018107	peptidyl-threonine phosphorylation
Biological Process	GO:0045740	positive regulation of DNA replication
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport
Biological Process	GO:0062033	positive regulation of mitotic sister chromatid segregation
Biological Process	GO:0042307	positive regulation of protein import into nucleus
Biological Process	GO:1900182	positive regulation of protein localization to nucleus
Biological Process	GO:0007344	pronuclear fusion
Biological Process	GO:0016579	protein deubiquitination
Biological Process	GO:0034501	protein localization to kinetochore
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0065003	protein-containing complex assembly
Biological Process	GO:0014038	regulation of Schwann cell differentiation
Biological Process	GO:0042752	regulation of circadian rhythm
Biological Process	GO:0045995	regulation of embryonic development
Biological Process	GO:0014823	response to activity
Biological Process	GO:0014075	response to amine
Biological Process	GO:0048678	response to axon injury
Biological Process	GO:0046686	response to cadmium ion
Biological Process	GO:0046688	response to copper ion
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0009636	response to toxic substance
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0048511	rhythmic process
Biological Process	GO:0055015	ventricular cardiac muscle cell development
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0001671	ATPase activator activity
Molecular Function	GO:0030544	Hsp70 protein binding
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity
Molecular Function	GO:0010698	acetyltransferase activator activity
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0030332	cyclin binding
Molecular Function	GO:0097472	cyclin-dependent protein kinase activity
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity
Molecular Function	GO:0008047	enzyme activator activity
Molecular Function	GO:0035173	histone kinase activity
Molecular Function	GO:0016301	kinase activity
Molecular Function	GO:0019210	kinase inhibitor activity
Molecular Function	GO:0004672	protein kinase activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0001618	virus receptor activity
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0097125	cyclin B1-CDK1 complex
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0030496	midbody
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005876	spindle microtubule

InterPro / Pfam

InterPro	InterPro name
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Pfam	Pfam name
PF00069	Protein kinase domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-110056	MAPK3 (ERK1) activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-1362300	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-170145	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-176412	Phosphorylation of the APC/C	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-176417	Phosphorylation of Emi1	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2299718	Condensation of Prophase Chromosomes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2465910	MASTL Facilitates Mitotic Progression	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2514853	Condensation of Prometaphase Chromosomes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2995383	Initiation of Nuclear Envelope (NE) Reformation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-380259	Loss of Nlp from mitotic centrosomes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	Leaf	R-HSA-1852241	Organelle biogenesis and maintenance
R-HSA-5687128	MAPK6/MAPK4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5689896	Ovarian tumor domain proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6804757	Regulation of TP53 Degradation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-68875	Mitotic Prophase	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-69205	G1/S-Specific Transcription	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-69478	G2/M DNA replication checkpoint	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8854518	AURKA Activation by TPX2	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8878166	Transcriptional regulation by RUNX2	Internal node	R-HSA-74160	Gene expression (Transcription)

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000250
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	ECO:0000269	PubMed:14654843
Cytoplasm, cytoskeleton, spindle
Mitochondrion	ECO:0000269	PubMed:19917720
Nucleus	ECO:0000250

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Medium	Enhanced
appendix	lymphoid tissue	Medium	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	glandular cells	Medium	Enhanced
cervix	glandular cells	Medium	Enhanced
cervix	squamous epithelial cells	Low	Enhanced
colon	glandular cells	Medium	Enhanced
duodenum	glandular cells	Medium	Enhanced
endometrium 1	cells in endometrial stroma	Medium	Enhanced
endometrium 1	glandular cells	Medium	Enhanced
endometrium 2	cells in endometrial stroma	Low	Enhanced
epididymis	glandular cells	Medium	Enhanced
esophagus	squamous epithelial cells	Medium	Enhanced
fallopian tube	glandular cells	Medium	Enhanced
kidney	cells in tubules	Medium	Enhanced
lung	macrophages	Medium	Enhanced
lymph node	germinal center cells	High	Enhanced
lymph node	non-germinal center cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	Medium	Enhanced
ovary	follicle cells	Low	Enhanced
pancreas	exocrine glandular cells	Low	Enhanced
parathyroid gland	glandular cells	Low	Enhanced
placenta	decidual cells	Medium	Enhanced
placenta	trophoblastic cells	Medium	Enhanced
prostate	glandular cells	Medium	Enhanced
rectum	glandular cells	Medium	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 2	cells in spinous layer	Medium	Enhanced
small intestine	glandular cells	Medium	Enhanced
spleen	cells in red pulp	Medium	Enhanced
spleen	cells in white pulp	Low	Enhanced
stomach 1	glandular cells	Medium	Enhanced
stomach 2	glandular cells	Medium	Enhanced
testis	pachytene spermatocytes	High	Enhanced
testis	preleptotene spermatocytes	Low	Enhanced
testis	spermatogonia cells	Low	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	Medium	Enhanced
tonsil	squamous epithelial cells	Medium	Enhanced
urinary bladder	urothelial cells	Medium	Enhanced
vagina	squamous epithelial cells	Medium	Enhanced

Summary of P06493

Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2
Protein: Cyclin-dependent kinase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P06493

Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2 Protein: Cyclin-dependent kinase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CDK1, CDC2, CDC28A, CDKN1, P34CDC2
Protein: Cyclin-dependent kinase 1