MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1IRJ	2.1	Crystal Structure of the MRP14 complexed with CHAPS
1XK4	1.8	Crystal structure of human calprotectin(S100A8/S100A9)
4GGF	1.6	Crystal structure of Mn2+ bound calprotectin
4XJK	1.76	Crystal structure of Mn(II) Ca(II) Na(I) bound calprotectin
5I8N		Solution Structure of human calcium-binding S100A9 (C3S) protein
5W1F	2.6	Crystal structure of Ni(II)- and Ca(II)-bound human calprotectin
6DS2	2.1	Crystal structure of Ni(II)-bound human calprotectin
7QUV	1.85	Crystal structure of human Calprotectin (S100A8/S100A9) in complex with Peptide 3
7UI5		Evolution avoids a pathological stabilizing interaction in the immune protein S100A9

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0014002	astrocyte development
Biological Process	GO:0035425	autocrine signaling
Biological Process	GO:0006914	autophagy
Biological Process	GO:0007267	cell-cell signaling
Biological Process	GO:0002544	chronic inflammatory response
Biological Process	GO:0042742	defense response to bacterium
Biological Process	GO:0050832	defense response to fungus
Biological Process	GO:0043542	endothelial cell migration
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response
Biological Process	GO:0035821	modulation of process of another organism
Biological Process	GO:0070488	neutrophil aggregation
Biological Process	GO:0030593	neutrophil chemotaxis
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation
Biological Process	GO:0035606	peptidyl-cysteine S-trans-nitrosylation
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:0030307	positive regulation of cell growth
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0051493	regulation of cytoskeleton organization
Biological Process	GO:0045113	regulation of integrin biosynthetic process
Biological Process	GO:0032496	response to lipopolysaccharide
Biological Process	GO:0032119	sequestering of zinc ion
Molecular Function	GO:0050786	RAGE receptor binding
Molecular Function	GO:0035662	Toll-like receptor 4 binding
Molecular Function	GO:0016209	antioxidant activity
Molecular Function	GO:0050544	arachidonic acid binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0034774	secretory granule lumen

InterPro / Pfam

InterPro	InterPro name
IPR001751	S100/Calcium binding protein 7/8-like, conserved site
IPR002048	EF-hand domain
IPR011992	EF-hand domain pair
IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
IPR018247	EF-Hand 1, calcium-binding site

Pfam	Pfam name
PF01023	S-100/ICaBP type calcium binding domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1236974	ER-Phagosome pathway	Leaf	R-HSA-168256	Immune System
R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Internal node	R-HSA-168256	Immune System
R-HSA-5602498	MyD88 deficiency (TLR2/4)	Leaf	R-HSA-1643685	Disease
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	Leaf	R-HSA-1643685	Disease
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5686938	Regulation of TLR by endogenous ligand	Leaf	R-HSA-168256	Immune System
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-6799990	Metal sequestration by antimicrobial proteins	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:18786929
Cytoplasm	ECO:0000269	PubMed:15598812
Cytoplasm	ECO:0000269	PubMed:8423249
Cytoplasm, cytoskeleton	ECO:0000269	PubMed:22489132
Cytoplasm, cytoskeleton	ECO:0000269	PubMed:9083090
Secreted

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
bone marrow	hematopoietic cells	High	Enhanced
cervix	squamous epithelial cells	High	Enhanced
endometrium	ciliated epithelial cells	Medium	Enhanced
endometrium	endothelial cells	High	Enhanced
endometrium	macrophages	High	Enhanced
endometrium	nonciliated glandular epithelial cells	Medium	Enhanced
endometrium	nonciliated luminal epithelial cells	Medium	Enhanced
endometrium	stromal fibroblasts	High	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
lung	macrophages	Medium	Enhanced
lymph node	non-germinal center cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 1	fibrohistiocytic cells	High	Enhanced
skin 1	hair follicles	Low	Enhanced
skin 1	sebaceous glands	High	Enhanced
skin 2	cells in basal layer	Medium	Enhanced
skin 2	cells in corneal layer	Medium	Enhanced
skin 2	cells in granular layer	High	Enhanced
skin 2	cells in spinous layer	High	Enhanced
skin 2	endothelial cells	Low	Enhanced
skin 2	fibrohistiocytic cells	High	Enhanced
skin 2	langerhans cells	High	Enhanced
spleen	cells in red pulp	High	Enhanced
spleen	cells in white pulp	Low	Enhanced
tonsil	non-germinal center cells	Medium	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
vagina	squamous epithelial cells	High	Enhanced

Disease

Summary of P06702

Gene: S100A9, CAGB, CFAG, MRP14
Protein: Protein S100-A9

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P06702

Gene: S100A9, CAGB, CFAG, MRP14 Protein: Protein S100-A9

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: S100A9, CAGB, CFAG, MRP14
Protein: Protein S100-A9