Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
4.2.1.11
Lyases;
Carbon-oxygen lyases;
Hydro-lyases;
phosphopyruvate hydratase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2PSN | 2.2 | Crystal structure of enolase1 |
| 3B97 | 2.2 | Crystal Structure of human Enolase 1 |
| 5JLZ | 1.99 | Crystal structure of HLA-DRB1*04:01 in complex with modified alpha-enolase peptide 26-40 with citrulline at the position 32 |
| 5LAX | 2.6 | Crystal structure of HLA_DRB1*04:01 in complex with alpha-enolase peptide 26-40 |
| 5NI9 | 1.33 | Crystal structure of HLA-DRB1*04:01 with the alpha-enolase peptide 326-340 |
| 5NIG | 1.35 | Crystal structure of HLA-DRB1*04:01 with modified alpha-enolase peptide 326-340 (arginine 327 to citrulline) |
| 5OCK | 1.6 | Crystal structure of ACPA E4 in complex with CEP1 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:1903298 | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:2001171 | positive regulation of ATP biosynthetic process |
| Biological Process | GO:0045933 | positive regulation of muscle contraction |
| Biological Process | GO:0010756 | positive regulation of plasminogen activation |
| Biological Process | GO:0009615 | response to virus |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0051020 | GTPase binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004634 | phosphopyruvate hydratase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Cellular Component | GO:0031430 | M band |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005640 | nuclear outer membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000015 | phosphopyruvate hydratase complex |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000941 | Enolase |
| IPR020809 | Enolase, conserved site |
| IPR020810 | Enolase, C-terminal TIM barrel domain |
| IPR020811 | Enolase, N-terminal |
| IPR029017 | Enolase-like, N-terminal |
| IPR036849 | Enolase-like, C-terminal domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00113 | Enolase, C-terminal TIM barrel domain |
| PF03952 | Enolase, N-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-70171 | Glycolysis | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-70263 | Gluconeogenesis | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9636667 | Manipulation of host energy metabolism | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:10802057 |
| Cytoplasm | ECO:0000269 | PubMed:10802057 |
| Cytoplasm, myofibril, sarcomere, M line | ECO:0000269 | PubMed:10802057 |
| Nucleus |