MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
5.3.1.9	Isomerases; Intramolecular oxidoreductases; Interconverting aldoses and ketoses, and related compounds; glucose-6-phosphate isomerase

Structure

PDB	Resolution (Å)	PDB name
1IAT	1.62	CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLUCOSE ISOMERASE/NEUROLEUKIN/AUTOCRINE MOTILITY FACTOR/MATURATION FACTOR
1IRI	2.4	Crystal structure of human autocrine motility factor complexed with an inhibitor
1JIQ	1.9	Crystal Structure of Human Autocrine Motility Factor
1JLH	2.1	Human Glucose-6-phosphate Isomerase
1NUH	2.51	The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate
6XUH	2.38	Crystal structure of human phosphoglucose isomerase in complex with inhibitor
6XUI	1.95	Crystal structure of human phosphoglucose isomerase in complex with inhibitor
8BBH	1.619	The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307

GO term

GO ontology	GO term	GO description
Biological Process	GO:0005975	carbohydrate metabolic process
Biological Process	GO:0034101	erythrocyte homeostasis
Biological Process	GO:0006094	gluconeogenesis
Biological Process	GO:0051156	glucose 6-phosphate metabolic process
Biological Process	GO:0042593	glucose homeostasis
Biological Process	GO:0006096	glycolytic process
Biological Process	GO:0007599	hemostasis
Biological Process	GO:0006959	humoral immune response
Biological Process	GO:0001701	in utero embryonic development
Biological Process	GO:0007611	learning or memory
Biological Process	GO:0001707	mesoderm formation
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:0010595	positive regulation of endothelial cell migration
Biological Process	GO:0002639	positive regulation of immunoglobulin production
Biological Process	GO:0046686	response to cadmium ion
Biological Process	GO:0032355	response to estradiol
Biological Process	GO:0035902	response to immobilization stress
Biological Process	GO:0043278	response to morphine
Biological Process	GO:0035994	response to muscle stretch
Biological Process	GO:0032570	response to progesterone
Biological Process	GO:0033574	response to testosterone
Molecular Function	GO:0097367	carbohydrate derivative binding
Molecular Function	GO:0005125	cytokine activity
Molecular Function	GO:0004347	glucose-6-phosphate isomerase activity
Molecular Function	GO:0008083	growth factor activity
Molecular Function	GO:0048029	monosaccharide binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Cellular Component	GO:0060170	ciliary membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0034774	secretory granule lumen

InterPro / Pfam

InterPro	InterPro name
IPR001672	Phosphoglucose isomerase (PGI)
IPR018189	Phosphoglucose isomerase, conserved site
IPR023096	Phosphoglucose isomerase, C-terminal
IPR035476	Phosphoglucose isomerase, SIS domain 1
IPR035482	Phosphoglucose isomerase, SIS domain 2
IPR046348	SIS domain superfamily

Pfam	Pfam name
PF00342	Phosphoglucose isomerase

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-5628897	TP53 Regulates Metabolic Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-70171	Glycolysis	Internal node	R-HSA-1430728	Metabolism
R-HSA-70263	Gluconeogenesis	Leaf	R-HSA-1430728	Metabolism

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:11437381
Secreted	ECO:0000269	PubMed:11437381

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000952	Jaundice
HP:0001081	Cholelithiasis
HP:0001082	Cholecystitis
HP:0001249	Intellectual disability
HP:0001251	Ataxia
HP:0001324	Muscle weakness
HP:0001744	Splenomegaly
HP:0001930	Nonspherocytic hemolytic anemia
HP:0003568	Decreased glucosephosphate isomerase level
HP:0005525	Spontaneous hemolytic crises
HP:0010871	Sensory ataxia
HP:0011981	Pigment gallstones
HP:0011993	Impaired neutrophil bactericidal activity

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Enhanced
adrenal gland	glandular cells	High	Enhanced
appendix	glandular cells	High	Enhanced
appendix	lymphoid tissue	Medium	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
breast	glandular cells	Medium	Enhanced
breast	myoepithelial cells	Low	Enhanced
bronchus	respiratory epithelial cells	Medium	Enhanced
caudate	neuronal cells	High	Enhanced
cerebellum	Purkinje cells	Medium	Enhanced
cerebellum	cells in granular layer	Medium	Enhanced
cerebellum	cells in molecular layer	Medium	Enhanced
cerebral cortex	glial cells	Medium	Enhanced
cerebral cortex	neuronal cells	Medium	Enhanced
cerebral cortex	neuropil	Medium	Enhanced
cervix	glandular cells	Medium	Enhanced
cervix	squamous epithelial cells	Medium	Enhanced
colon	endothelial cells	Medium	Enhanced
colon	glandular cells	High	Enhanced
colon	peripheral nerve/ganglion	Low	Enhanced
duodenum	glandular cells	High	Enhanced
endometrium 1	cells in endometrial stroma	Low	Enhanced
endometrium 1	glandular cells	Medium	Enhanced
endometrium 2	glandular cells	Medium	Enhanced
epididymis	glandular cells	Medium	Enhanced
esophagus	squamous epithelial cells	Medium	Enhanced
fallopian tube	glandular cells	High	Enhanced
gallbladder	glandular cells	High	Enhanced
heart muscle	cardiomyocytes	High	Enhanced
hippocampus	glial cells	Low	Enhanced
hippocampus	neuronal cells	Medium	Enhanced
kidney	cells in tubules	High	Enhanced
liver	hepatocytes	Medium	Enhanced
lung	alveolar cells	Low	Enhanced
lung	macrophages	Medium	Enhanced
lymph node	non-germinal center cells	High	Enhanced
oral mucosa	squamous epithelial cells	Medium	Enhanced
ovary	ovarian stroma cells	Low	Enhanced
pancreas	exocrine glandular cells	High	Enhanced
pancreas	pancreatic endocrine cells	High	Enhanced
parathyroid gland	glandular cells	High	Enhanced
placenta	trophoblastic cells	Low	Enhanced
prostate	glandular cells	High	Enhanced
rectum	glandular cells	High	Enhanced
salivary gland	glandular cells	Medium	Enhanced
seminal vesicle	glandular cells	Medium	Enhanced
skeletal muscle	myocytes	Medium	Enhanced
skin 1	Langerhans	Medium	Enhanced
skin 1	fibroblasts	High	Enhanced
skin 1	keratinocytes	Medium	Enhanced
skin 1	melanocytes	High	Enhanced
skin 2	epidermal cells	Medium	Enhanced
small intestine	glandular cells	High	Enhanced
smooth muscle	smooth muscle cells	Low	Enhanced
soft tissue 1	chondrocytes	High	Enhanced
soft tissue 1	fibroblasts	Medium	Enhanced
soft tissue 2	fibroblasts	Medium	Enhanced
spleen	cells in red pulp	High	Enhanced
spleen	cells in white pulp	Medium	Enhanced
stomach 1	glandular cells	Medium	Enhanced
stomach 2	glandular cells	High	Enhanced
testis	Leydig cells	High	Enhanced
testis	cells in seminiferous ducts	Medium	Enhanced
thyroid gland	glandular cells	High	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	High	Enhanced
tonsil	squamous epithelial cells	Medium	Enhanced
urinary bladder	urothelial cells	High	Enhanced
vagina	squamous epithelial cells	Medium	Enhanced

Disease

Summary of P06744

Gene: GPI
Protein: Glucose-6-phosphate isomerase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P06744

Gene: GPI Protein: Glucose-6-phosphate isomerase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: GPI
Protein: Glucose-6-phosphate isomerase