MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.1.32	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; phospholipase A1
3.1.1.34	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; lipoprotein lipase

Structure

PDB	Resolution (Å)	PDB name
6E7K	2.8	Structure of the lipoprotein lipase GPIHBP1 complex that mediates plasma triglyceride hydrolysis
6OAU	2.48	Apo Structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in GnTI-deficient HEK293-F cells
6OAZ	3.04	Apo Structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in HEK293-F cells
6OB0	2.81	Compound 2 bound structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in HEK293-F cells
6WN4	2.8	Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase

GO term

GO ontology	GO term	GO description
Biological Process	GO:0071398	cellular response to fatty acid
Biological Process	GO:0031670	cellular response to nutrient
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0034371	chylomicron remodeling
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0016042	lipid catabolic process
Biological Process	GO:0055096	low-density lipoprotein particle mediated signaling
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus
Biological Process	GO:0006644	phospholipid metabolic process
Biological Process	GO:1904179	positive regulation of adipose tissue development
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process	GO:0032722	positive regulation of chemokine production
Biological Process	GO:0010886	positive regulation of cholesterol storage
Biological Process	GO:0045600	positive regulation of fat cell differentiation
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production
Biological Process	GO:0032755	positive regulation of interleukin-6 production
Biological Process	GO:0010884	positive regulation of lipid storage
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation
Biological Process	GO:0010890	positive regulation of sequestering of triglyceride
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0009617	response to bacterium
Biological Process	GO:0009409	response to cold
Biological Process	GO:0009749	response to glucose
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0019432	triglyceride biosynthetic process
Biological Process	GO:0019433	triglyceride catabolic process
Biological Process	GO:0070328	triglyceride homeostasis
Biological Process	GO:0006641	triglyceride metabolic process
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling
Molecular Function	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Molecular Function	GO:0034185	apolipoprotein binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0016298	lipase activity
Molecular Function	GO:0004465	lipoprotein lipase activity
Molecular Function	GO:0071813	lipoprotein particle binding
Molecular Function	GO:0052739	phosphatidylserine 1-acylhydrolase activity
Molecular Function	GO:0008970	phospholipase A1 activity
Molecular Function	GO:0004620	phospholipase activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0043495	protein-membrane adaptor activity
Molecular Function	GO:0005102	signaling receptor binding
Molecular Function	GO:0017129	triglyceride binding
Molecular Function	GO:0004806	triglyceride lipase activity
Cellular Component	GO:1902494	catalytic complex
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0042627	chylomicron
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0034361	very-low-density lipoprotein particle

InterPro	InterPro name
IPR000734	Triacylglycerol lipase family
IPR001024	PLAT/LH2 domain
IPR002330	Lipoprotein lipase
IPR013818	Lipase
IPR016272	Lipase, LIPH-type
IPR029058	Alpha/Beta hydrolase fold
IPR033906	Lipase, N-terminal
IPR036392	PLAT/LH2 domain superfamily

Pfam	Pfam name
PF00151	Lipase
PF01477	PLAT/LH2 domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-8963889	Assembly of active LPL and LIPC lipase complexes	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-8963901	Chylomicron remodeling	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-975634	Retinoid metabolism and transport	Leaf	R-HSA-9709957	Sensory Perception

Location	ECO term	Pubmed
Cell membrane	ECO:0000250
Secreted	ECO:0000269	PubMed:11342582
Secreted	ECO:0000269	PubMed:11893776
Secreted	ECO:0000269	PubMed:12641539
Secreted	ECO:0000269	PubMed:1371284
Secreted	ECO:0000269	PubMed:2340307
Secreted	ECO:0000269	PubMed:27578112
Secreted	ECO:0000269	PubMed:30559189
Secreted, extracellular space, extracellular matrix	ECO:0000269	PubMed:27811232

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000660	Lipemia retinalis
HP:0000952	Jaundice
HP:0001013	Eruptive xanthomas
HP:0001114	Xanthelasma
HP:0001433	Hepatosplenomegaly
HP:0001626	Abnormality of the cardiovascular system
HP:0001658	Myocardial infarction
HP:0001733	Pancreatitis
HP:0001744	Splenomegaly
HP:0002013	Vomiting
HP:0002018	Nausea
HP:0002574	Episodic abdominal pain
HP:0003077	Hyperlipidemia
HP:0003124	Hypercholesterolemia
HP:0003141	Increased LDL cholesterol concentration
HP:0003362	Increased VLDL cholesterol concentration
HP:0004416	Precocious atherosclerosis
HP:0012238	Increased circulating chylomicron concentration
HP:0031028	Lactescent serum
HP:0031798	Elevated circulating apolipoprotein B concentration
HP:0031800	Elevated circulating apolipoprotein A-II concentration

Summary of P06858

Gene: LPL, LIPD
Protein: Lipoprotein lipase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
hyperlipidemia, familial combined, lpl related	MONDO:0007759	E78	chapter4, Endocrine, nutritional and metabolic diseases	OMIM:144250
familial lipoprotein lipase deficiency	MONDO:0009387	E78	chapter4, Endocrine, nutritional and metabolic diseases	OMIM:238600	Orphanet:309015

Summary of P06858

Gene: LPL, LIPD Protein: Lipoprotein lipase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: LPL, LIPD
Protein: Lipoprotein lipase