MultifacetedProtDB - Bologna Biocomputing Group

Summary of P07320

Gene: CRYGD, CRYG4
Protein: Gamma-crystallin D

Protein family
Protein sequence
Protein function

Catalytic activity

The protein has not catalytic activity

Publications

Structure

Link to AlphaFold model

PDB	Resolution (Å)	PDB name
1H4A	1.15	Human GammaD Crystallin R58H mutant structure AT 1.15 A resolution
1HK0	1.25	Human GammaD Crystallin Structure at 1.25 A Resolution
2G98	2.2	human gamma-D-crystallin
2KFB		The structure of the cataract causing P23T mutant of human gamma-D crystallin
2KLJ		Solution Structure of gammaD-Crystallin with RDC and SAXS
4GR7	1.7	The human W42R Gamma D-Crystallin Mutant Structure at 1.7A Resolution
4JGF	2.5	Crystal Structure of the Cataract-Causing P23T gamma D-Crystallin Mutant
6ETA	2.198	Crystal Structure of Human Gamma-D crystallin Mutant P23T+R36S at Room Temperature
6ETC	1.197	Crystal Structure of Human gamma-D-crystallin Mutant P23T+R36S at 1.2 Angstroms Resolution
6W5B	1.15	N124D Deamidation Mutant of Human gammaD-Crystallin
6WCY	1.204	N160D Deamidation Mutant of Human gammaD-Crystallin
7P53	1.57	Crystal Structure of Human gamma-D-crystallin mutant C110M at 1.57 Angstroms resolution

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
cataract 4 multiple types	MONDO:0007281	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:115700	Orphanet:91492
cataract 4 multiple types	MONDO:0007281	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:115700	Orphanet:98989
cataract 4 multiple types	MONDO:0007281	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:115700	Orphanet:98990
cataract 4 multiple types	MONDO:0007281	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:115700	Orphanet:98991
cataract 4 multiple types	MONDO:0007281	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:115700	Orphanet:98995
pulverulent cataract	MONDO:0011430	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98984
pulverulent cataract	MONDO:0011430	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98986
pulverulent cataract	MONDO:0011430	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98995
cataract - microcornea syndrome	MONDO:0015300	Q13	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:1377
early-onset lamellar cataract	MONDO:0018611	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:441452
cerulean cataract	MONDO:0020374	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98989
coralliform cataract	MONDO:0020375	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98990
early-onset nuclear cataract	MONDO:0020376	Q12	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:98991