Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1W7B | 1.52 | Annexin A2: Does it induce membrane aggregation by a new multimeric state of the protein. |
1XJL | 2.59 | Structure of human annexin A2 in the presence of calcium ions |
2HYU | 1.86 | Human Annexin A2 with heparin tetrasaccharide bound |
2HYV | 1.42 | Human Annexin A2 with heparin hexasaccharide bound |
2HYW | 2.1 | Human Annexin A2 with Calcium bound |
4DRW | 3.5 | Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an AHNAK Peptide |
4FTG | 2.5054 | The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer |
4HRH | 3.001 | Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide |
5LPU | 2.1 | Crystal structure of Annexin A2 complexed with S100A4 |
5LPX | 1.9 | Crystal structure of PKC phosphorylation-mimicking mutant (S26E) Annexin A2 |
5LQ0 | 2.9 | Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution |
5LQ2 | 3.4 | Crystal structure of Tyr24 phosphorylated Annexin A2 at 3.4 A resolution |
5N7D | 2.3 | MAGI-1 complexed with a RSK1 peptide |
5N7F | 2.3 | MAGI-1 complexed with a pRSK1 peptide |
5N7G | 2.95 | MAGI-1 complexed with a synthetic pRSK1 peptide |
6TWQ | 2.65 | MAGI1_2 complexed with a 16E6 peptide |
6TWU | 2.4 | MAGI1_2 complexed with a phosphomimetic 16E6 peptide |
6TWX | 2.3 | MAGI1_2 complexed with a phosphorylated 16E6 peptide |
6TWY | 2.3 | MAGI1_2 complexed with a phosphomimetic RSK1 peptide |
7DTO | 2.8 | Human Annexin A2 with C132-C261 intramolecular disulfide bond |
7EQ7 | 2.111 | Co-Crystal Structure Analysis of Annexin A2 and 5alpha-EAL |
7NMI | 2.1 | Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization chaperone |
7P70 | 2.0 | The PDZ-domain of SNTB1 complexed with the PDZ-binding motif of HPV35-E6 |
7P71 | 2.6 | The PDZ domain of MAGI1_2 complexed with the PDZ-binding motif of HPV35-E6 |
7P72 | 2.15 | The PDZ domain of SNX27 complexed with the PDZ-binding motif of MERS-E |
7P73 | 1.85 | The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1 |
7P74 | 1.9 | The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1 |
7PC3 | 1.95 | The second PDZ domain of DLG1 complexed with the PDZ-binding motif of HTLV1-TAX1 |
7PC4 | 2.3 | The PDZ domain of SNTB1 complexed with the PDZ-binding motif of HTLV1-TAX1 |
7PC5 | 1.7 | The third PDZ domain of PDZD7 complexed with the PDZ-binding motif of EXOC4 |
7PC7 | 2.1 | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN |
7PC8 | 2.5 | The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ-binding motif of RSK1 |
7PC9 | 2.4 | The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1 |
7PCB | 2.0 | The PDZ domain of SNX27 fused with ANXA2 |
7QQL | 2.44 | The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 |
7QQM | 1.6 | The PDZ domain of LRRC7 fused with ANXA2 |
7QQN | 2.45 | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of TRPV3 |
7ZVN | 1.87 | Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution |
7ZVX | 2.4 | Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0001525 | angiogenesis |
Biological Process | GO:0030199 | collagen fibril organization |
Biological Process | GO:0042730 | fibrinolysis |
Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
Biological Process | GO:0001765 | membrane raft assembly |
Biological Process | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process |
Biological Process | GO:0002091 | negative regulation of receptor internalization |
Biological Process | GO:0036035 | osteoclast development |
Biological Process | GO:0045921 | positive regulation of exocytosis |
Biological Process | GO:1905581 | positive regulation of low-density lipoprotein particle clearance |
Biological Process | GO:1905597 | positive regulation of low-density lipoprotein particle receptor binding |
Biological Process | GO:1905599 | positive regulation of low-density lipoprotein receptor activity |
Biological Process | GO:1905686 | positive regulation of plasma membrane repair |
Biological Process | GO:0010756 | positive regulation of plasminogen activation |
Biological Process | GO:0001921 | positive regulation of receptor recycling |
Biological Process | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Biological Process | GO:0044090 | positive regulation of vacuole organization |
Biological Process | GO:0031340 | positive regulation of vesicle fusion |
Biological Process | GO:0050767 | regulation of neurogenesis |
Biological Process | GO:0006900 | vesicle budding from membrane |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0044548 | S100 protein binding |
Molecular Function | GO:0098641 | cadherin binding involved in cell-cell adhesion |
Molecular Function | GO:0005262 | calcium channel activity |
Molecular Function | GO:0005509 | calcium ion binding |
Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
Molecular Function | GO:0048306 | calcium-dependent protein binding |
Molecular Function | GO:0008092 | cytoskeletal protein binding |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
Molecular Function | GO:0001786 | phosphatidylserine binding |
Molecular Function | GO:0019834 | phospholipase A2 inhibitor activity |
Molecular Function | GO:0002020 | protease binding |
Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
Molecular Function | GO:0046790 | virion binding |
Cellular Component | GO:1990665 | AnxA2-p11 complex |
Cellular Component | GO:1990667 | PCSK9-AnxA2 complex |
Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
Cellular Component | GO:0043220 | Schmidt-Lanterman incisure |
Cellular Component | GO:0005912 | adherens junction |
Cellular Component | GO:0035578 | azurophil granule lumen |
Cellular Component | GO:0005604 | basement membrane |
Cellular Component | GO:0016323 | basolateral plasma membrane |
Cellular Component | GO:0009986 | cell surface |
Cellular Component | GO:0062023 | collagen-containing extracellular matrix |
Cellular Component | GO:0001533 | cornified envelope |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005769 | early endosome |
Cellular Component | GO:0005768 | endosome |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005576 | extracellular region |
Cellular Component | GO:0005615 | extracellular space |
Cellular Component | GO:0031902 | late endosome membrane |
Cellular Component | GO:0005811 | lipid droplet |
Cellular Component | GO:0005765 | lysosomal membrane |
Cellular Component | GO:0042470 | melanosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0030496 | midbody |
Cellular Component | GO:0035749 | myelin sheath adaxonal region |
Cellular Component | GO:0016363 | nuclear matrix |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0005886 | plasma membrane |
Cellular Component | GO:0098797 | plasma membrane protein complex |
Cellular Component | GO:0042383 | sarcolemma |
Cellular Component | GO:0031982 | vesicle |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-445355 | Smooth Muscle Contraction | Leaf | R-HSA-397014 | Muscle contraction |
R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
R-HSA-75205 | Dissolution of Fibrin Clot | Leaf | R-HSA-109582 | Hemostasis |
R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | Leaf | R-HSA-168256 | Immune System |
Location | ECO term | Pubmed |
---|---|---|
Melanosome | ECO:0000269 | PubMed:17081065 |
Secreted, extracellular space, extracellular matrix, basement membrane | ECO:0000269 | PubMed:17081065 |