MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1LSL	1.9	Crystal Structure of the Thrombospondin-1 Type 1 Repeats
1UX6	1.9	Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats
1Z78	1.8	Crystal Structure of the Thrombospondin-1 N-terminal domain
1ZA4	1.9	Crystal Structure of the Thrombospondin-1 N-terminal Domain in Complex with Arixtra
2ERF	1.45	Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution
2ES3	1.85	Crystal Structure of Thrombospondin-1 N-terminal Domain in P1 Form at 1.85A Resolution
2OUH	2.4	Crystal structure of the Thrombospondin-1 N-terminal domain in complex with fractionated Heparin DP10
2OUJ	1.9	The crystal structure of the Thrombospondin-1 N-terminal domain in complex with fractionated Heparin DP8
3R6B	2.4	Crystal Structure of Thrombospondin-1 TSR Domains 2 and 3
5FOE	1.98	Crystal structure of the C. elegans Protein O-fucosyltransferase 2 (CePOFUT2) double mutant (R298K-R299K) in complex with GDP and the human TSR1 from thrombospondin 1
7YYK	2.6	Crystal structure of the O-fucosylated form of TSRs1-3 from the human thrombospondin 1

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0048266	behavioral response to pain
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0016477	cell migration
Biological Process	GO:0071363	cellular response to growth factor stimulus
Biological Process	GO:0034605	cellular response to heat
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0002544	chronic inflammatory response
Biological Process	GO:0043652	engulfment of apoptotic cell
Biological Process	GO:0006955	immune response
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Biological Process	GO:0010754	negative regulation of cGMP-mediated signaling
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0002605	negative regulation of dendritic cell antigen processing and presentation
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis
Biological Process	GO:0010596	negative regulation of endothelial cell migration
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
Biological Process	GO:0051918	negative regulation of fibrinolysis
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
Biological Process	GO:0051895	negative regulation of focal adhesion assembly
Biological Process	GO:0032695	negative regulation of interleukin-12 production
Biological Process	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction
Biological Process	GO:0010757	negative regulation of plasminogen activation
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis
Biological Process	GO:0018149	peptide cross-linking
Biological Process	GO:0043406	positive regulation of MAP kinase activity
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0030194	positive regulation of blood coagulation
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0050921	positive regulation of chemotaxis
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process
Biological Process	GO:0010595	positive regulation of endothelial cell migration
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Process	GO:0010763	positive regulation of fibroblast migration
Biological Process	GO:0043032	positive regulation of macrophage activation
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis
Biological Process	GO:0042327	positive regulation of phosphorylation
Biological Process	GO:0051897	positive regulation of protein kinase B signaling
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process	GO:0032914	positive regulation of transforming growth factor beta1 production
Biological Process	GO:0045727	positive regulation of translation
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production
Biological Process	GO:0051592	response to calcium ion
Biological Process	GO:0034976	response to endoplasmic reticulum stress
Biological Process	GO:0009749	response to glucose
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0032026	response to magnesium ion
Biological Process	GO:0009612	response to mechanical stimulus
Biological Process	GO:0032570	response to progesterone
Biological Process	GO:0033574	response to testosterone
Biological Process	GO:0006986	response to unfolded protein
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0002040	sprouting angiogenesis
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0070052	collagen V binding
Molecular Function	GO:0004866	endopeptidase inhibitor activity
Molecular Function	GO:0005201	extracellular matrix structural constituent
Molecular Function	GO:0070051	fibrinogen binding
Molecular Function	GO:0017134	fibroblast growth factor binding
Molecular Function	GO:0001968	fibronectin binding
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0005178	integrin binding
Molecular Function	GO:0043236	laminin binding
Molecular Function	GO:0030169	low-density lipoprotein particle binding
Molecular Function	GO:0001786	phosphatidylserine binding
Molecular Function	GO:0002020	protease binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0043394	proteoglycan binding
Molecular Function	GO:0050431	transforming growth factor beta binding
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0009897	external side of plasma membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005577	fibrinogen complex
Cellular Component	GO:0031091	platelet alpha granule
Cellular Component	GO:0031093	platelet alpha granule lumen
Cellular Component	GO:0016529	sarcoplasmic reticulum
Cellular Component	GO:0030141	secretory granule

InterPro / Pfam

InterPro	InterPro name
IPR000742	EGF-like domain
IPR000884	Thrombospondin type-1 (TSP1) repeat
IPR001007	VWFC domain
IPR001791	Laminin G domain
IPR001881	EGF-like calcium-binding domain
IPR003367	Thrombospondin, type 3-like repeat
IPR008859	Thrombospondin, C-terminal
IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
IPR017897	Thrombospondin, type 3 repeat
IPR028974	TSP type-3 repeat
IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily

Pfam	Pfam name
PF00090	Thrombospondin type 1 domain
PF00093	von Willebrand factor type C domain
PF02412	Thrombospondin type 3 repeat
PF05735	Thrombospondin C-terminal region

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-114608	Platelet degranulation	Leaf	R-HSA-109582	Hemostasis
R-HSA-186797	Signaling by PDGF	Internal node	R-HSA-162582	Signal Transduction
R-HSA-216083	Integrin cell surface interactions	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-3000170	Syndecan interactions	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-5083635	Defective B3GALTL causes PpS	Leaf	R-HSA-1643685	Disease
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Leaf	R-HSA-74160	Gene expression (Transcription)

Subcellular location

Location	ECO term	Pubmed
Cell surface	ECO:0000269	PubMed:6777381
Endoplasmic reticulum	ECO:0000250
Sarcoplasmic reticulum	ECO:0000250
Secreted	ECO:0000269	PubMed:101549
Secreted	ECO:0000269	PubMed:14568985
Secreted	ECO:0000269	PubMed:6777381
Secreted, extracellular space, extracellular matrix	ECO:0000269	PubMed:18285447
Secreted, extracellular space, extracellular matrix	ECO:0000269	PubMed:6341993

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	glandular cells	Low	Approved
breast	myoepithelial cells	High	Approved
bronchus	basal cells	Low	Approved
bronchus	ciliated cells (ciliary rootlets)	Medium	Approved
cerebral cortex	endothelial cells	Medium	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	Low	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	High	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	Low	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
endometrium 2	glandular cells	Low	Approved
epididymis	glandular cells	High	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	ciliated cells (cell body)	Low	Approved
fallopian tube	ciliated cells (ciliary rootlets)	High	Approved
fallopian tube	non-ciliated cells	Low	Approved
gallbladder	glandular cells	High	Approved
heart muscle	cardiomyocytes	High	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	Medium	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	Medium	Approved
lymph node	germinal center cells	High	Approved
lymph node	non-germinal center cells	High	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	High	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Low	Approved
placenta	trophoblastic cells	Medium	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Low	Approved
seminal vesicle	glandular cells	High	Approved
skeletal muscle	myocytes	Low	Approved
skin 1	fibroblasts	Low	Approved
skin 1	keratinocytes	Medium	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	High	Approved
soft tissue 1	fibroblasts	Low	Approved
soft tissue 1	peripheral nerve	Low	Approved
spleen	cells in red pulp	High	Approved
spleen	cells in white pulp	Medium	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	High	Approved
testis	Leydig cells	Medium	Approved
testis	elongated or late spermatids	Medium	Approved
testis	sertoli cells	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Low	Approved

Summary of P07996

Gene: THBS1, TSP, TSP1
Protein: Thrombospondin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P07996

Gene: THBS1, TSP, TSP1 Protein: Thrombospondin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: THBS1, TSP, TSP1
Protein: Thrombospondin-1