MultifacetedProtDB - Bologna Biocomputing Group

Summary of P08183

Gene: ABCB1, MDR1, PGY1
Protein: ATP-dependent translocase ABCB1

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
7.6.2.1	Translocases; Catalysing the translocation of other compounds; Linked to the hydrolysis of a nucleoside triphosphate; P-type phospholipid transporter
7.6.2.2	Translocases; Catalysing the translocation of other compounds; Linked to the hydrolysis of a nucleoside triphosphate; ABC-type xenobiotic transporter

Publications

Structure

Link to AlphaFold model

PDB	Resolution (Å)	PDB name
6C0V	3.4	Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
6FN1	3.58	Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
6FN4	4.14	Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
6QEX	3.6	Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol
7A65	3.9	Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab
7A69	3.2	Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine
7A6C	3.6	Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and elacridar
7A6E	3.6	Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar
7A6F	3.5	Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and zosuquidar
7O9W	3.5	Encequidar-bound human P-glycoprotein in complex with UIC2-Fab

GO term

GO ontology	GO term	GO description
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle
Biological Process	GO:1905039	carboxylic acid transmembrane transport
Biological Process	GO:0099040	ceramide translocation
Biological Process	GO:0140115	export across plasma membrane
Biological Process	GO:0045332	phospholipid translocation
Biological Process	GO:1901529	positive regulation of anion channel activity
Biological Process	GO:2001225	regulation of chloride transport
Biological Process	GO:0047484	regulation of response to osmotic stress
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0072089	stem cell proliferation
Biological Process	GO:0046865	terpenoid transport
Biological Process	GO:0070633	transepithelial transport
Biological Process	GO:0055085	transmembrane transport
Biological Process	GO:0150104	transport across blood-brain barrier
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane
Biological Process	GO:0006805	xenobiotic metabolic process
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity
Molecular Function	GO:0046943	carboxylic acid transmembrane transporter activity
Molecular Function	GO:0099038	ceramide floppase activity
Molecular Function	GO:0015562	efflux transmembrane transporter activity
Molecular Function	GO:0140328	floppase activity
Molecular Function	GO:0090554	phosphatidylcholine floppase activity
Molecular Function	GO:0090555	phosphatidylethanolamine flippase activity
Molecular Function	GO:0022857	transmembrane transporter activity
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0098591	external side of apical plasma membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane

InterPro / Pfam

InterPro	InterPro name
IPR003439	ABC transporter-like, ATP-binding domain
IPR003593	AAA+ ATPase domain
IPR011527	ABC transporter type 1, transmembrane domain
IPR017871	ABC transporter-like, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR036640	ABC transporter type 1, transmembrane domain superfamily
IPR039421	Type 1 protein exporter

Pfam	Pfam name
PF00005	ABC transporter
PF00664	ABC transporter transmembrane region

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2161517	Abacavir transmembrane transport	Leaf	R-HSA-9748784	Drug ADME
R-HSA-382556	ABC-family proteins mediated transport	Internal node	R-HSA-382551	Transport of small molecules
R-HSA-9754706	Atorvastatin ADME	Leaf	R-HSA-9748784	Drug ADME
R-HSA-9757110	Prednisone ADME	Leaf	R-HSA-9748784	Drug ADME

Subcellular location

Location	ECO term	Pubmed
Apical cell membrane	ECO:0000269	PubMed:28408210
Apical cell membrane	ECO:0000269	PubMed:8898203
Cell membrane	ECO:0000269	PubMed:35970996
Cytoplasm	ECO:0000269	PubMed:35970996

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0002037	Inflammation of the large intestine

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Enhanced
caudate	glial cells	Low	Enhanced
cerebral cortex	endothelial cells	High	Enhanced
cerebral cortex	neuropil	Low	Enhanced
colon	glandular cells	Low	Enhanced
fallopian tube	glandular cells	Low	Enhanced
gallbladder	glandular cells	Medium	Enhanced
hippocampus	glial cells	Low	Enhanced
kidney	cells in tubules	Low	Enhanced
liver	cholangiocytes	Medium	Enhanced
liver	hepatocytes	Low	Enhanced
ovary	follicle cells	Low	Enhanced
small intestine	glandular cells	Low	Enhanced

Summary of P08183

Gene: ABCB1, MDR1, PGY1 Protein: ATP-dependent translocase ABCB1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ABCB1, MDR1, PGY1
Protein: ATP-dependent translocase ABCB1