MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1QZ2	3.0	Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
1UYM	2.45	Human Hsp90-beta with PU3 (9-Butyl-8(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine)
2L6J		Tah1 complexed by MEEVD
3FWV	2.2	Crystal Structure of a Redesigned TPR Protein, T-MOD(VMY), in Complex with MEEVF Peptide
3NMQ	2.2	Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor
3PRY	2.28	Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
3UQ3	2.6	TPR2AB-domain:pHSP90-complex of yeast Sti1
5FWK	3.9	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5FWL	9.0	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5FWM	8.0	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5FWP	7.2	Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex
5UC4	2.05	Hsp90b N-terminal domain with inhibitors
5UCH	2.654	Hsp90b N-terminal domain with inhibitors
5UCI	2.7	Hsp90b N-terminal domain with inhibitors
5UCJ	1.693	Hsp90b N-terminal domain with inhibitors
6N8W	3.09228	Structure of Unliganded Hsp90-Beta N-Terminal Domain
6N8Y	1.55391	Hsp90-beta bound to PU-11-trans
7Z37	3.67	Structure of the RAF1-HSP90-CDC37 complex (RHC-II)
7Z38	3.16	Structure of the RAF1-HSP90-CDC37 complex (RHC-I)
7ZR0	3.4	CryoEM structure of HSP90-CDC37-BRAF(V600E) complex.
7ZR5	3.9	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
7ZR6	4.2	CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex
7ZUB	2.85	Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex
8EOA	3.9	Cryo-EM structure of human HSP90B-AIPL1 complex
8EOB	3.1	Cryo-EM structure of human HSP90B in the closed state

GO term

GO ontology	GO term	GO description
Biological Process	GO:0048675	axon extension
Biological Process	GO:0034605	cellular response to heat
Biological Process	GO:0071353	cellular response to interleukin-4
Biological Process	GO:0021955	central nervous system neuron axonogenesis
Biological Process	GO:0051131	chaperone-mediated protein complex assembly
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1901799	negative regulation of proteasomal protein catabolic process
Biological Process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:0051248	negative regulation of protein metabolic process
Biological Process	GO:1901389	negative regulation of transforming growth factor beta activation
Biological Process	GO:0001890	placenta development
Biological Process	GO:0045597	positive regulation of cell differentiation
Biological Process	GO:1904031	positive regulation of cyclin-dependent protein kinase activity
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation
Biological Process	GO:0032516	positive regulation of phosphoprotein phosphatase activity
Biological Process	GO:0051897	positive regulation of protein kinase B signaling
Biological Process	GO:2000010	positive regulation of protein localization to cell surface
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity
Biological Process	GO:0051973	positive regulation of telomerase activity
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process	GO:0006457	protein folding
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0032880	regulation of protein localization
Biological Process	GO:0031396	regulation of protein ubiquitination
Biological Process	GO:0006986	response to unfolded protein
Biological Process	GO:0097435	supramolecular fiber organization
Biological Process	GO:1905323	telomerase holoenzyme complex assembly
Biological Process	GO:0007004	telomere maintenance via telomerase
Biological Process	GO:0019062	virion attachment to host cell
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0043008	ATP-dependent protein binding
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone
Molecular Function	GO:0070182	DNA polymerase binding
Molecular Function	GO:0023026	MHC class II protein complex binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0030911	TPR domain binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0097718	disordered domain specific binding
Molecular Function	GO:0003725	double-stranded RNA binding
Molecular Function	GO:0031072	heat shock protein binding
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:1990226	histone methyltransferase binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0030235	nitric-oxide synthase regulator activity
Molecular Function	GO:0042277	peptide binding
Molecular Function	GO:0046983	protein dimerization activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0019887	protein kinase regulator activity
Molecular Function	GO:0048156	tau protein binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0051082	unfolded protein binding
Cellular Component	GO:1990565	HSP90-CDC37 chaperone complex
Cellular Component	GO:0034751	aryl hydrocarbon receptor complex
Cellular Component	GO:0044295	axonal growth cone
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0044294	dendritic growth cone
Cellular Component	GO:0120293	dynein axonemal particle
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0042470	melanosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0034774	secretory granule lumen

InterPro / Pfam

InterPro	InterPro name
IPR001404	Heat shock protein Hsp90 family
IPR003594	Histidine kinase/HSP90-like ATPase
IPR019805	Heat shock protein Hsp90, conserved site
IPR020568	Ribosomal protein S5 domain 2-type fold
IPR020575	Heat shock protein Hsp90, N-terminal
IPR036890	Histidine kinase/HSP90-like ATPase superfamily
IPR037196	HSP90, C-terminal domain

Pfam	Pfam name
PF00183	Hsp90 protein
PF02518	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	Internal node	R-HSA-168256	Immune System
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	Leaf	R-HSA-168256	Immune System
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3371511	HSF1 activation	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3371568	Attenuation phase	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3371571	HSF1-dependent transactivation	Internal node	R-HSA-8953897	Cellular responses to stimuli
R-HSA-399954	Sema3A PAK dependent Axon repulsion	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-5336415	Uptake and function of diphtheria toxin	Leaf	R-HSA-1643685	Disease
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-844456	The NLRP3 inflammasome	Leaf	R-HSA-168256	Immune System
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8937144	Aryl hydrocarbon receptor signalling	Leaf	R-HSA-1430728	Metabolism
R-HSA-8939211	ESR-mediated signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-9013418	RHOBTB2 GTPase cycle	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9018519	Estrogen-dependent gene expression	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9613829	Chaperone Mediated Autophagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-9660826	Purinergic signaling in leishmaniasis infection	Leaf	R-HSA-1643685	Disease
R-HSA-9679191	Potential therapeutics for SARS	Leaf	R-HSA-1643685	Disease
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:20599762
Cell surface	ECO:0000269	PubMed:21949862
Cytoplasm	ECO:0000269	PubMed:16580629
Cytoplasm	ECO:0000269	PubMed:18239673
Cytoplasm	ECO:0000269	PubMed:24880080
Cytoplasm	ECO:0000269	PubMed:9482106
Dynein axonemal particle	ECO:0000250
Melanosome	ECO:0000269	PubMed:17081065
Nucleus	ECO:0000269	PubMed:18239673
Secreted	ECO:0000269	PubMed:20599762

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Enhanced
adrenal gland	glandular cells	High	Enhanced
appendix	endocrine cells	Medium	Enhanced
appendix	enterocytes	Medium	Enhanced
appendix	goblet cells	Medium	Enhanced
appendix	non-germinal center cells	Medium	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
breast	adipocytes	Medium	Enhanced
breast	glandular cells	Medium	Enhanced
breast	myoepithelial cells	Medium	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
caudate	glial cells	Medium	Enhanced
caudate	neuronal cells	Medium	Enhanced
cerebellum	Purkinje cells	Medium	Enhanced
cerebellum	cells in granular layer	Low	Enhanced
cerebellum	cells in molecular layer	High	Enhanced
cerebral cortex	endothelial cells	Low	Enhanced
cerebral cortex	glial cells	Medium	Enhanced
cerebral cortex	neuronal cells	Medium	Enhanced
cerebral cortex	neuropil	Low	Enhanced
cervix	glandular cells	Medium	Enhanced
cervix	squamous epithelial cells	Medium	Enhanced
colon	endocrine cells	Medium	Enhanced
colon	endothelial cells	Medium	Enhanced
colon	enterocytes	Medium	Enhanced
colon	goblet cells	Medium	Enhanced
colon	mucosal lymphoid cells	High	Enhanced
colon	peripheral nerve/ganglion	High	Enhanced
duodenum	endocrine cells	Low	Enhanced
duodenum	enterocytes	Low	Enhanced
duodenum	goblet cells	Low	Enhanced
endometrium 1	cells in endometrial stroma	Low	Enhanced
endometrium 1	glandular cells	High	Enhanced
endometrium 2	cells in endometrial stroma	Low	Enhanced
endometrium 2	glandular cells	Medium	Enhanced
epididymis	glandular cells	High	Enhanced
esophagus	squamous epithelial cells	Medium	Enhanced
fallopian tube	glandular cells	High	Enhanced
gallbladder	glandular cells	Medium	Enhanced
heart muscle	cardiomyocytes	Medium	Enhanced
hippocampus	glial cells	Medium	Enhanced
hippocampus	neuronal cells	Medium	Enhanced
kidney	cells in glomeruli	Low	Enhanced
kidney	cells in tubules	Medium	Enhanced
liver	cholangiocytes	Medium	Enhanced
liver	hepatocytes	Medium	Enhanced
lung	alveolar cells type II	High	Enhanced
lung	macrophages	Medium	Enhanced
lymph node	germinal center cells	High	Enhanced
lymph node	non-germinal center cells	High	Enhanced
nasopharynx	respiratory epithelial cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	Medium	Enhanced
ovary	ovarian stroma cells	Medium	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
pancreas	pancreatic endocrine cells	Medium	Enhanced
parathyroid gland	glandular cells	Medium	Enhanced
placenta	decidual cells	High	Enhanced
placenta	trophoblastic cells	High	Enhanced
prostate	glandular cells	High	Enhanced
rectum	endocrine cells	Medium	Enhanced
rectum	endothelial cells	Medium	Enhanced
rectum	enterocytes	Medium	Enhanced
rectum	goblet cells	Medium	Enhanced
rectum	mucosal lymphoid cells	High	Enhanced
salivary gland	glandular cells	Low	Enhanced
skeletal muscle	myocytes	Medium	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	cells in granular layer	Medium	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 1	endothelial cells	Medium	Enhanced
skin 1	fibrohistiocytic cells	Medium	Enhanced
skin 1	langerhans cells	Medium	Enhanced
skin 1	lymphocytes	Medium	Enhanced
skin 1	melanocytes	Medium	Enhanced
skin 2	cells in basal layer	Medium	Enhanced
skin 2	cells in granular layer	Medium	Enhanced
skin 2	cells in spinous layer	Medium	Enhanced
skin 2	endothelial cells	Medium	Enhanced
skin 2	fibrohistiocytic cells	Medium	Enhanced
skin 2	langerhans cells	Medium	Enhanced
skin 2	lymphocytes	Medium	Enhanced
skin 2	melanocytes	Medium	Enhanced
small intestine	endocrine cells	High	Enhanced
small intestine	enterocytes	High	Enhanced
small intestine	goblet cells	High	Enhanced
smooth muscle	smooth muscle cells	Medium	Enhanced
soft tissue 1	chondrocytes	High	Enhanced
soft tissue 1	fibroblasts	Medium	Enhanced
soft tissue 1	peripheral nerve	Medium	Enhanced
soft tissue 2	fibroblasts	Medium	Enhanced
spleen	cells in red pulp	Low	Enhanced
spleen	cells in white pulp	Medium	Enhanced
stomach 1	glandular cells	Medium	Enhanced
stomach 2	glandular cells	Medium	Enhanced
testis	Leydig cells	Medium	Enhanced
testis	elongated or late spermatids	Low	Enhanced
testis	sertoli cells	Medium	Enhanced
testis	spermatogonia cells	High	Enhanced
thyroid gland	glandular cells	Medium	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	High	Enhanced
tonsil	squamous epithelial cells	Medium	Enhanced
urinary bladder	urothelial cells	High	Enhanced
vagina	squamous epithelial cells	Low	Enhanced

Summary of P08238

Gene: HSP90AB1, HSP90B, HSPC2, HSPCB
Protein: Heat shock protein HSP 90-beta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P08238

Gene: HSP90AB1, HSP90B, HSPC2, HSPCB Protein: Heat shock protein HSP 90-beta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: HSP90AB1, HSP90B, HSPC2, HSPCB
Protein: Heat shock protein HSP 90-beta