MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.4.24.24	Hydrolases; Acting on peptide bonds (peptidases); Metalloendopeptidases; gelatinase A

Structure

PDB	Resolution (Å)	PDB name
1CK7	2.8	GELATINASE A (FULL-LENGTH)
1CXW		THE SECOND TYPE II MODULE FROM HUMAN MATRIX METALLOPROTEINASE 2
1EAK	2.66	Catalytic domain of proMMP-2 E404Q mutant
1GEN	2.15	C-TERMINAL DOMAIN OF GELATINASE A
1GXD	3.1	proMMP-2/TIMP-2 complex
1HOV		SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020
1J7M		The Third Fibronectin Type II Module from Human Matrix Metalloproteinase 2
1KS0		The First Fibronectin Type II Module from Human Matrix Metalloproteinase 2
1QIB	2.8	CRYSTAL STRUCTURE OF GELATINASE A CATALYTIC DOMAIN
1RTG	2.6	C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2
3AYU	2.0	Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor
7XGJ	2.8	Crystal structure of human MMP-2 catalytic domain in complex with inhibitor
7XJO	2.0	Crystal structure of human MMP-2 catalytic domain in complex with inhibitor

GO term

GO ontology	GO term	GO description
Biological Process	GO:0007568	aging
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0001955	blood vessel maturation
Biological Process	GO:0060346	bone trabecula formation
Biological Process	GO:0071492	cellular response to UV-A
Biological Process	GO:0071230	cellular response to amino acid stimulus
Biological Process	GO:0071392	cellular response to estradiol stimulus
Biological Process	GO:0071498	cellular response to fluid shear stress
Biological Process	GO:0071347	cellular response to interleukin-1
Biological Process	GO:0034614	cellular response to reactive oxygen species
Biological Process	GO:0030574	collagen catabolic process
Biological Process	GO:0007566	embryo implantation
Biological Process	GO:0035987	endodermal cell differentiation
Biological Process	GO:0048013	ephrin receptor signaling pathway
Biological Process	GO:0022617	extracellular matrix disassembly
Biological Process	GO:0030198	extracellular matrix organization
Biological Process	GO:0060325	face morphogenesis
Biological Process	GO:0007507	heart development
Biological Process	GO:0001957	intramembranous ossification
Biological Process	GO:0001553	luteinization
Biological Process	GO:0048246	macrophage chemotaxis
Biological Process	GO:0007162	negative regulation of cell adhesion
Biological Process	GO:0045906	negative regulation of vasoconstriction
Biological Process	GO:0001541	ovarian follicle development
Biological Process	GO:0001542	ovulation from ovarian follicle
Biological Process	GO:0007567	parturition
Biological Process	GO:0014012	peripheral nervous system axon regeneration
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation
Biological Process	GO:0060740	prostate gland epithelium morphogenesis
Biological Process	GO:0030163	protein catabolic process
Biological Process	GO:0019538	protein metabolic process
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0014823	response to activity
Biological Process	GO:1904645	response to amyloid-beta
Biological Process	GO:0051602	response to electrical stimulus
Biological Process	GO:0043627	response to estrogen
Biological Process	GO:0042542	response to hydrogen peroxide
Biological Process	GO:0055093	response to hyperoxia
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0009612	response to mechanical stimulus
Biological Process	GO:0035094	response to nicotine
Biological Process	GO:0032526	response to retinoic acid
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0048771	tissue remodeling
Molecular Function	GO:0004175	endopeptidase activity
Molecular Function	GO:0001968	fibronectin binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Molecular Function	GO:0008237	metallopeptidase activity
Molecular Function	GO:0004252	serine-type endopeptidase activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0030017	sarcomere

InterPro / Pfam

InterPro	InterPro name
IPR000562	Fibronectin type II domain
IPR000585	Hemopexin-like domain
IPR001818	Peptidase M10, metallopeptidase
IPR002477	Peptidoglycan binding-like
IPR006026	Peptidase, metallopeptidase
IPR013806	Kringle-like fold
IPR018486	Hemopexin, conserved site
IPR018487	Hemopexin-like repeats
IPR021158	Peptidase M10A, cysteine switch, zinc binding site
IPR021190	Peptidase M10A
IPR024079	Metallopeptidase, catalytic domain superfamily
IPR033739	Peptidase M10A, catalytic domain
IPR036365	PGBD-like superfamily
IPR036375	Hemopexin-like domain superfamily
IPR036943	Fibronectin type II domain superfamily

Pfam	Pfam name
PF00040	Fibronectin type II domain
PF00045	Hemopexin
PF00413	Matrixin
PF01471	Putative peptidoglycan binding domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1442490	Collagen degradation	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-1474228	Degradation of the extracellular matrix	Internal node	R-HSA-1474244	Extracellular matrix organization
R-HSA-1592389	Activation of Matrix Metalloproteinases	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	Leaf	R-HSA-168256	Immune System
R-HSA-9009391	Extra-nuclear estrogen signaling	Internal node	R-HSA-162582	Signal Transduction

Subcellular location

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000147	Polycystic ovaries
HP:0000212	Gingival overgrowth
HP:0000248	Brachycephaly
HP:0000280	Coarse facial features
HP:0000315	Abnormality of the orbital region
HP:0000316	Hypertelorism
HP:0000327	Hypoplasia of the maxilla
HP:0000347	Micrognathia
HP:0000414	Bulbous nose
HP:0000446	Narrow nasal bridge
HP:0000520	Proptosis
HP:0000612	Iris coloboma
HP:0000684	Delayed eruption of teeth
HP:0000822	Hypertension
HP:0000916	Broad clavicles
HP:0000938	Osteopenia
HP:0000939	Osteoporosis
HP:0001007	Hirsutism
HP:0001034	Hypermelanotic macule
HP:0001059	Pterygium
HP:0001072	Thickened skin
HP:0001085	Papilledema
HP:0001171	Split hand
HP:0001220	Interphalangeal joint contracture of finger
HP:0001230	Broad metacarpals
HP:0001239	Wrist flexion contracture
HP:0001249	Intellectual disability
HP:0001288	Gait disturbance
HP:0001369	Arthritis
HP:0001473	Metatarsal osteolysis
HP:0001476	Delayed closure of the anterior fontanelle
HP:0001482	Subcutaneous nodule
HP:0001495	Carpal osteolysis
HP:0001504	Metacarpal osteolysis
HP:0001539	Omphalocele
HP:0001626	Abnormality of the cardiovascular system
HP:0001629	Ventricular septal defect
HP:0001631	Atrial septal defect
HP:0001634	Mitral valve prolapse
HP:0001647	Bicuspid aortic valve
HP:0001678	Atrioventricular block
HP:0001680	Coarctation of aorta
HP:0001719	Double outlet right ventricle
HP:0001761	Pes cavus
HP:0001763	Pes planus
HP:0001783	Broad metatarsal
HP:0001836	Camptodactyly of toe
HP:0001999	Abnormal facial shape
HP:0002007	Frontal bossing
HP:0002659	Increased susceptibility to fractures
HP:0002751	Kyphoscoliosis
HP:0002753	Thin bony cortex
HP:0002797	Osteolysis
HP:0002829	Arthralgia
HP:0002953	Vertebral compression fracture
HP:0003016	Metaphyseal widening
HP:0003040	Arthropathy
HP:0003179	Protrusio acetabuli
HP:0003273	Hip contracture
HP:0003312	Abnormal form of the vertebral bodies
HP:0003320	C1-C2 subluxation
HP:0003493	Antinuclear antibody positivity
HP:0003593	Infantile onset
HP:0003621	Juvenile onset
HP:0004322	Short stature
HP:0005441	Sclerotic cranial sutures
HP:0005922	Abnormal hand morphology
HP:0005994	Nodular goiter
HP:0006012	Widened metacarpal shaft
HP:0006086	Thin metacarpal cortices
HP:0006234	Osteolysis involving tarsal bones
HP:0006252	Interphalangeal joint erosions
HP:0006466	Ankle flexion contracture
HP:0007957	Corneal opacity
HP:0008011	Peripheral opacification of the cornea
HP:0008078	Thin metatarsal cortices
HP:0008090	Ankylosis of feet small joints
HP:0008133	Distal tapering of metatarsals
HP:0009139	Osteolysis involving bones of the lower limbs
HP:0010314	Premature thelarche
HP:0010537	Wide cranial sutures
HP:0011355	Localized skin lesion
HP:0011463	Childhood onset
HP:0025131	Finger swelling
HP:0045039	Osteolysis involving bones of the upper limbs
HP:0100651	Type I diabetes mellitus

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
bronchus	ciliated cells (cell body)	Low	Approved
cerebral cortex	endothelial cells	High	Approved
cervix	glandular cells	Low	Approved
colon	endothelial cells	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
fallopian tube	ciliated cells (ciliary rootlets)	Low	Approved
fallopian tube	ciliated cells (tip of cilia)	Medium	Approved
fallopian tube	non-ciliated cells	Low	Approved
heart muscle	cardiomyocytes	Low	Approved
kidney	cells in glomeruli	Low	Approved
lung	alveolar cells	Medium	Approved
lung	macrophages	Medium	Approved
parathyroid gland	glandular cells	Low	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	Low	Approved
smooth muscle	smooth muscle cells	Low	Approved
spleen	cells in red pulp	Low	Approved
testis	Leydig cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved

Disease

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
multicentric osteolysis- nodulosis- and arthropathy	MONDO:0009809	M89	chapter13, Diseases of the musculoskeletal system and connective tissue	OMIM:259600
multicentric osteolysis-nodulosis-arthropathy spectrum	MONDO:0018298	Q85	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:371428

Location	ECO term	Pubmed
Cytoplasm
Membrane
Mitochondrion
Nucleus
Secreted, extracellular space, extracellular matrix	ECO:0000305	PubMed:2834383

Summary of P08253

Gene: MMP2, CLG4A
Protein: 72 kDa type IV collagenase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P08253

Gene: MMP2, CLG4A Protein: 72 kDa type IV collagenase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: MMP2, CLG4A
Protein: 72 kDa type IV collagenase