MultifacetedProtDB - Bologna Biocomputing Group

Summary of P08254

Gene: MMP3, STMY1
Protein: Stromelysin-1

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
3.4.24.17	Hydrolases; Acting on peptide bonds (peptidases); Metalloendopeptidases; stromelysin 1

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Publications

Structure

Link to AlphaFold model

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PDB	Resolution (Å)	PDB name
1B3D	2.3	STROMELYSIN-1
1B8Y	2.0	X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXED WITH NON-PEPTIDE INHIBITORS: IMPLICATIONS FOR INHIBITOR SELECTIVITY
1BIW	2.5	DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS
1BM6		SOLUTION STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 COMPLEXED TO A POTENT NON-PEPTIDIC INHIBITOR, NMR, 20 STRUCTURES
1BQO	2.3	DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS
1C3I	1.83	HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
1C8T	2.6	HUMAN STROMELYSIN-1 (E202Q) CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
1CAQ	1.8	X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXES WITH NON-PEPTIDE INHIBITORS: IMPLICATION FOR INHIBITOR SELECTIVITY
1CIZ	1.64	X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXES WITH NON-PEPTIDE INHIBITORS: IMPLICATION FOR INHIBITOR SELECTIVITY
1CQR	2.0	CRYSTAL STRUCTURE OF THE STROMELYSIN CATALYTIC DOMAIN AT 2.0 A RESOLUTION

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GO term

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GO ontology	GO term	GO description
Biological Process	GO:0071492	cellular response to UV-A
Biological Process	GO:0071732	cellular response to nitric oxide
Biological Process	GO:0030574	collagen catabolic process
Biological Process	GO:0022617	extracellular matrix disassembly
Biological Process	GO:0030198	extracellular matrix organization
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0010727	negative regulation of hydrogen peroxide metabolic process
Biological Process	GO:1903209	positive regulation of oxidative stress-induced cell death
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly
Biological Process	GO:0006508	proteolysis

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InterPro / Pfam

Reactome

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Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1442490	Collagen degradation	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-1474228	Degradation of the extracellular matrix	Internal node	R-HSA-1474244	Extracellular matrix organization
R-HSA-1592389	Activation of Matrix Metalloproteinases	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	Internal node	R-HSA-1474244	Extracellular matrix organization
R-HSA-2179392	EGFR Transactivation by Gastrin	Leaf	R-HSA-162582	Signal Transduction
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	Leaf	R-HSA-168256	Immune System
R-HSA-9009391	Extra-nuclear estrogen signaling	Internal node	R-HSA-162582	Signal Transduction

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Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease