Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.1.1.23
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
acylglycerol lipase
3.1.1.6
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
acetylesterase
3.1.1.79
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
hormone-sensitive lipase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007340 | acrosome reaction |
| Biological Process | GO:0046464 | acylglycerol catabolic process |
| Biological Process | GO:0051792 | medium-chain fatty acid biosynthetic process |
| Biological Process | GO:0051793 | medium-chain fatty acid catabolic process |
| Biological Process | GO:0014912 | negative regulation of smooth muscle cell migration |
| Biological Process | GO:0032570 | response to progesterone |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0014909 | smooth muscle cell migration |
| Biological Process | GO:0048240 | sperm capacitation |
| Biological Process | GO:0043401 | steroid hormone mediated signaling pathway |
| Molecular Function | GO:0008126 | acetylesterase activity |
| Molecular Function | GO:0047372 | acylglycerol lipase activity |
| Molecular Function | GO:0042562 | hormone binding |
| Molecular Function | GO:0033878 | hormone-sensitive lipase activity |
| Molecular Function | GO:0003707 | nuclear steroid receptor activity |
| Molecular Function | GO:0004806 | triglyceride lipase activity |
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0097524 | sperm plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000305 | |
| Cell projection, cilium, flagellum membrane | ECO:0000305 | PubMed:26989199 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | High | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | High | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | High | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | Low | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | High | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | Low | Approved |
| kidney | cells in tubules | Low | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | High | Approved |
| lymph node | germinal center cells | High | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | High | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| spleen | cells in red pulp | Low | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | High | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | High | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|