MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1BAS	1.9	THREE-DIMENSIONAL STRUCTURES OF ACIDIC AND BASIC FIBROBLAST GROWTH FACTORS
1BFB	1.9	BASIC FIBROBLAST GROWTH FACTOR COMPLEXED WITH HEPARIN TETRAMER FRAGMENT
1BFC	2.2	BASIC FIBROBLAST GROWTH FACTOR COMPLEXED WITH HEPARIN HEXAMER FRAGMENT
1BFF	2.0	THE 154 AMINO ACID FORM OF HUMAN BASIC FIBROBLAST GROWTH FACTOR
1BFG	1.6	CRYSTAL STRUCTURE OF BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION
1BLA		BASIC FIBROBLAST GROWTH FACTOR (FGF-2) MUTANT WITH CYS 78 REPLACED BY SER AND CYS 96 REPLACED BY SER, NMR
1BLD		BASIC FIBROBLAST GROWTH FACTOR (FGF-2) MUTANT WITH CYS 78 REPLACED BY SER AND CYS 96 REPLACED BY SER, NMR
1CVS	2.8	CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
1EV2	2.2	CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
1FGA	2.2	REFINEMENT OF THE STRUCTURE OF HUMAN BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION AND ANALYSIS OF PRESUMED HEPARIN BINDING SITES BY SELENATE SUBSTITUTION
1FQ9	3.0	CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
1II4	2.7	CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
1IIL	2.3	CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2
2BFH	2.5	CRYSTAL STRUCTURE OF BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION
2FGF	1.77	THREE-DIMENSIONAL STRUCTURE OF HUMAN BASIC FIBROBLAST GROWTH FACTOR, A STRUCTURAL HOMOLOG OF INTERLEUKIN 1BETA
2M49		Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction
4FGF	1.6	REFINEMENT OF THE STRUCTURE OF HUMAN BASIC FIBROBLAST GROWTH FACTOR AT 1.6 ANGSTROMS RESOLUTION AND ANALYSIS OF PRESUMED HEPARIN BINDING SITES BY SELENATE SUBSTITUTION
4OEE	1.5	Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex
4OEF	1.8	Crystal Structure Analysis of FGF2-Disaccharide (S6I2) complex
4OEG	1.6	Crystal Structure Analysis of FGF2-Disaccharide (S9I2) complex
5X1O	1.9	PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study
6L4O	2.6	Crystal structure of API5-FGF2 complex

GO term

GO ontology	GO term	GO description
Biological Process	GO:0070371	ERK1 and ERK2 cascade
Biological Process	GO:0007265	Ras protein signal transduction
Biological Process	GO:0007568	aging
Biological Process	GO:0060978	angiogenesis involved in coronary vascular morphogenesis
Biological Process	GO:0009887	animal organ morphogenesis
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis
Biological Process	GO:0060070	canonical Wnt signaling pathway
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis
Biological Process	GO:0071260	cellular response to mechanical stimulus
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation
Biological Process	GO:0006935	chemotaxis
Biological Process	GO:0060591	chondroblast differentiation
Biological Process	GO:0060128	corticotropin hormone secreting cell differentiation
Biological Process	GO:0009792	embryo development ending in birth or egg hatching
Biological Process	GO:0048598	embryonic morphogenesis
Biological Process	GO:0001935	endothelial cell proliferation
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway
Biological Process	GO:0010001	glial cell differentiation
Biological Process	GO:0014843	growth factor dependent regulation of skeletal muscle satellite cell proliferation
Biological Process	GO:0030214	hyaluronan catabolic process
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation
Biological Process	GO:0032958	inositol phosphate biosynthetic process
Biological Process	GO:0030324	lung development
Biological Process	GO:1904977	lymphatic endothelial cell migration
Biological Process	GO:0060644	mammary gland epithelial cell differentiation
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
Biological Process	GO:0010764	negative regulation of fibroblast migration
Biological Process	GO:0010629	negative regulation of gene expression
Biological Process	GO:2000647	negative regulation of stem cell proliferation
Biological Process	GO:0061045	negative regulation of wound healing
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0007405	neuroblast proliferation
Biological Process	GO:0001759	organ induction
Biological Process	GO:0001649	osteoblast differentiation
Biological Process	GO:0038001	paracrine signaling
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0043406	positive regulation of MAP kinase activity
Biological Process	GO:0043410	positive regulation of MAPK cascade
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation
Biological Process	GO:0051781	positive regulation of cell division
Biological Process	GO:0042660	positive regulation of cell fate specification
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis
Biological Process	GO:2000546	positive regulation of endothelial cell chemotaxis to fibroblast growth factor
Biological Process	GO:0010595	positive regulation of endothelial cell migration
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation
Biological Process	GO:1905278	positive regulation of epithelial tube formation
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0045609	positive regulation of inner ear auditory receptor cell differentiation
Biological Process	GO:1902748	positive regulation of lens fiber cell differentiation
Biological Process	GO:1902895	positive regulation of miRNA transcription
Biological Process	GO:0002052	positive regulation of neuroblast proliferation
Biological Process	GO:1902913	positive regulation of neuroepithelial cell differentiation
Biological Process	GO:0045669	positive regulation of osteoblast differentiation
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process	GO:0010863	positive regulation of phospholipase C activity
Biological Process	GO:0051897	positive regulation of protein kinase B signaling
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis
Biological Process	GO:2000738	positive regulation of stem cell differentiation
Biological Process	GO:2000648	positive regulation of stem cell proliferation
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation
Biological Process	GO:0043491	protein kinase B signaling
Biological Process	GO:0045765	regulation of angiogenesis
Biological Process	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0030334	regulation of cell migration
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis
Biological Process	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor
Biological Process	GO:0046668	regulation of retinal cell programmed cell death
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol
Biological Process	GO:0048678	response to axon injury
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0048864	stem cell development
Biological Process	GO:0072089	stem cell proliferation
Biological Process	GO:0021762	substantia nigra development
Biological Process	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation
Biological Process	GO:0006366	transcription by RNA polymerase II
Biological Process	GO:0042060	wound healing
Molecular Function	GO:0042056	chemoattractant activity
Molecular Function	GO:0019956	chemokine binding
Molecular Function	GO:0005125	cytokine activity
Molecular Function	GO:0005104	fibroblast growth factor receptor binding
Molecular Function	GO:0008083	growth factor activity
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0005178	integrin binding
Molecular Function	GO:0030374	nuclear receptor coactivator activity
Molecular Function	GO:0090722	receptor-receptor interaction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

InterPro	InterPro name
IPR002209	Fibroblast growth factor family
IPR008996	Cytokine IL1/FGF

Pfam	Pfam name
PF00167	Fibroblast growth factor

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-109704	PI3K Cascade	Internal node	R-HSA-162582	Signal Transduction
R-HSA-1257604	PIP3 activates AKT signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-1839122	Signaling by activated point mutants of FGFR1	Leaf	R-HSA-1643685	Disease
R-HSA-1839130	Signaling by activated point mutants of FGFR3	Leaf	R-HSA-1643685	Disease
R-HSA-190322	FGFR4 ligand binding and activation	Internal node	R-HSA-162582	Signal Transduction
R-HSA-190370	FGFR1b ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190372	FGFR3c ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190373	FGFR1c ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190375	FGFR2c ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-190377	FGFR2b ligand binding and activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2033519	Activated point mutants of FGFR2	Leaf	R-HSA-1643685	Disease
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	Leaf	R-HSA-1643685	Disease
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-3000170	Syndecan interactions	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-3000171	Non-integrin membrane-ECM interactions	Internal node	R-HSA-1474244	Extracellular matrix organization
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654687	Downstream signaling of activated FGFR1	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654688	SHC-mediated cascade:FGFR1	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654689	PI-3K cascade:FGFR1	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654693	FRS-mediated FGFR1 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654695	PI-3K cascade:FGFR2	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654699	SHC-mediated cascade:FGFR2	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654700	FRS-mediated FGFR2 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654704	SHC-mediated cascade:FGFR3	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654706	FRS-mediated FGFR3 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654710	PI-3K cascade:FGFR3	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654712	FRS-mediated FGFR4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654719	SHC-mediated cascade:FGFR4	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654720	PI-3K cascade:FGFR4	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654726	Negative regulation of FGFR1 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654727	Negative regulation of FGFR2 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654732	Negative regulation of FGFR3 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5654733	Negative regulation of FGFR4 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5655253	Signaling by FGFR2 in disease	Internal node	R-HSA-1643685	Disease
R-HSA-5655302	Signaling by FGFR1 in disease	Internal node	R-HSA-1643685	Disease
R-HSA-5655332	Signaling by FGFR3 in disease	Internal node	R-HSA-1643685	Disease
R-HSA-5658623	FGFRL1 modulation of FGFR1 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5673001	RAF/MAP kinase cascade	Internal node	R-HSA-162582	Signal Transduction
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	Leaf	R-HSA-168256	Immune System
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8851708	Signaling by FGFR2 IIIa TM	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Nucleus	ECO:0000269	PubMed:22321063
Secreted	ECO:0000269	PubMed:20230531

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	adipocytes	Medium	Enhanced
breast	myoepithelial cells	Medium	Enhanced
caudate	glial cells	High	Enhanced
caudate	synapses	Medium	Enhanced
cerebellum	Bergmann glia - nucleus	High	Enhanced
cerebellum	granular cells - nucleus	High	Enhanced
cerebellum	molecular layer cells - nucleus	High	Enhanced
cerebellum	white matter cells - nucleus	High	Enhanced
cerebral cortex	endothelial cells	Low	Enhanced
cerebral cortex	glial cells	Medium	Enhanced
colon	endothelial cells	Medium	Enhanced
endometrium 1	cells in endometrial stroma	Low	Enhanced
fallopian tube	glandular cells	Medium	Enhanced
hippocampus	glial cells	Medium	Enhanced
hippocampus	neuronal cells	Low	Enhanced
kidney	cells in glomeruli	Medium	Enhanced
kidney	cells in tubules	Medium	Enhanced
liver	hepatocytes	Low	Enhanced
lung	alveolar cells type I	Medium	Enhanced
lung	alveolar cells type II	Medium	Enhanced
lung	endothelial cells	High	Enhanced
ovary	ovarian stroma cells	Medium	Enhanced
seminal vesicle	glandular cells	Low	Enhanced
skin 1	fibroblasts	Medium	Enhanced
smooth muscle	smooth muscle cells	High	Enhanced
soft tissue 1	fibroblasts	Medium	Enhanced
soft tissue 2	fibroblasts	Medium	Enhanced
thyroid gland	glandular cells	Low	Enhanced

Summary of P09038

Gene: FGF2, FGFB
Protein: Fibroblast growth factor 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P09038

Gene: FGF2, FGFB Protein: Fibroblast growth factor 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: FGF2, FGFB
Protein: Fibroblast growth factor 2