Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
1GZW | 1.7 | X-RAY CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 |
1W6M | 2.3 | X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH GALACTOSE |
1W6N | 1.65 | X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 |
1W6O | 1.9 | X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH LACTOSE |
1W6P | 1.8 | X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH N- Acetyl-LACTOSAMINE |
1W6Q | 2.1 | X-RAY CRYSTAL STRUCTURE OF R111H HUMAN GALECTIN-1 |
2KM2 | Galectin-1 dimer | |
2ZKN | 1.86 | X-ray structure of mutant galectin-1/lactose complex |
3OY8 | 2.19 | Crystal structure of human galectin-1 in complex with lactobionic acid |
3OYW | 2.5 | Crystal structure of human galectin-1 in complex with thiodigalactoside |
3T2T | 1.9 | Crystal structure of human galectin-1 in complex with methyl 2-O-acetyl-3-O-toluoyl-beta-D-talopyranoside |
3W58 | 1.58 | Crystal structure of Galectin-1 in the lactose-unbound state(P21) |
3W59 | 2.1 | Crystal structure of Galectin-1 in the lactose-unbound state(P212121) |
4Q1P | 1.46 | Galectin-1 in Complex with Ligand NB169 |
4Q1R | 1.47 | Galectin-1 in Complex with Ligand AN027 |
4Q26 | 1.399 | Crystal Structure of Galectin-1 in Complex with N-Acetyllactosamine |
4Q27 | 1.2 | Galectin-1 in Complex with a Click-Activated N-Acetyllactosamine |
4Q2F | 1.4 | Galectin-1 in Complex with Ligand AN020 |
4XBL | 1.931 | Crystal Structure of Human Galectin-1 in Complex with Type 1 N-acetyllactosamine |
4Y1U | 1.762 | Complex of human Galectin-1 and Galbeta1-4GlcNAc |
4Y1V | 2.32 | Complex of human Galectin-1 and Galbeta1-3GlcNAc |
4Y1X | 2.45 | Complex of human Galectin-1 and Galbeta1-4(6OSO3)GlcNAc |
4Y1Y | 1.86 | Complex of human Galectin-1 and (6OSO3)Galbeta1-3GlcNAc |
4Y1Z | 2.23 | Complex of human Galectin-1 and Galbeta1-4(6CO2)GlcNAc |
4Y20 | 2.204 | Complex of human Galectin-1 and NeuAcalpha2-3Galbeta1-4Glc |
4Y22 | 2.5 | Complex of human Galectin-1 and (3OSO3)Galbeta1-3GlcNAc |
4Y24 | 2.32 | Complex of human Galectin-1 and TD-139 |
5MWT | 1.711 | Galectin-1 in Complex with Ligand JB97 |
5MWX | 1.29 | Galectin-1 in Complex with Ligand JB60 |
6B94 | 1.8 | Crystal structure of Human galectin-1 in complex with Lactulose |
6F83 | 2.2 | Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl Thiodigalactoside Inhibitor |
6M5Y | 1.38 | Structure of human galectin-1 tandem-repeat mutant with lactose |
7LTA | 1.53 | Galectin-1 in complex with Trehalose |
7NML | 1.43 | Galectin-1 in complex with 4-Amino-6-chloro-1,3-benzenedisulfonamide |
GO ontology
|
GO term | GO description |
---|---|---|
Biological Process | GO:0031295 | T cell costimulation |
Biological Process | GO:0006915 | apoptotic process |
Biological Process | GO:0098609 | cell-cell adhesion |
Biological Process | GO:0045445 | myoblast differentiation |
Biological Process | GO:0002317 | plasma cell differentiation |
Biological Process | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
Biological Process | GO:0043065 | positive regulation of apoptotic process |
Biological Process | GO:0050729 | positive regulation of inflammatory response |
Biological Process | GO:0046598 | positive regulation of viral entry into host cell |
Biological Process | GO:0042981 | regulation of apoptotic process |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0030246 | carbohydrate binding |
Molecular Function | GO:0043236 | laminin binding |
Cellular Component | GO:0062023 | collagen-containing extracellular matrix |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005576 | extracellular region |
Cellular Component | GO:0005615 | extracellular space |
Cellular Component | GO:1990724 | galectin complex |
Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-8957275 | Post-translational protein phosphorylation | Leaf | R-HSA-392499 | Metabolism of proteins |
Location
|
ECO term
|
Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:32272059 |
Secreted | ECO:0000269 | PubMed:32272059 |
Secreted, extracellular space, extracellular matrix | ECO:0000269 | PubMed:14617626 |