MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.5.1.18	Transferases; Transferring alkyl or aryl groups, other than methyl groups; Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date); glutathione transferase

Structure

PDB	Resolution (Å)	PDB name
1GTU	2.68	LIGAND-FREE HUMAN GLUTATHIONE S-TRANSFERASE M1A-1A
1XW6	1.9	1.9 angstrom resolution structure of human glutathione S-transferase M1A-1A complexed with glutathione
1XWK	2.3	2.3 angstrom resolution crystal structure of human glutathione S-transferase M1A-1A complexed with glutathionyl-S-dinitrobenzene
1YJ6	2.5	crystal structure of human glutathione S-transferase M1A-1A complexed with glutathionyl-zinc-trihydroxide
2F3M	2.7	Structure of human GLUTATHIONE S-TRANSFERASE M1A-1A complexed with 1-(S-(GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXADIENATE ANION
7BEU	1.59	Human glutathione transferase M1-1

GO term

GO ontology	GO term	GO description
Biological Process	GO:0070458	cellular detoxification of nitrogen compound
Biological Process	GO:1901687	glutathione derivative biosynthetic process
Biological Process	GO:0006749	glutathione metabolic process
Biological Process	GO:0051122	hepoxilin biosynthetic process
Biological Process	GO:0018916	nitrobenzene metabolic process
Biological Process	GO:0006693	prostaglandin metabolic process
Biological Process	GO:0042178	xenobiotic catabolic process
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0043295	glutathione binding
Molecular Function	GO:0004364	glutathione transferase activity
Molecular Function	GO:0042803	protein homodimerization activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0045171	intercellular bridge

InterPro / Pfam

InterPro	InterPro name
IPR003081	Glutathione S-transferase, Mu class
IPR004045	Glutathione S-transferase, N-terminal
IPR004046	Glutathione S-transferase, C-terminal
IPR010987	Glutathione S-transferase, C-terminal-like
IPR036249	Thioredoxin-like superfamily
IPR036282	Glutathione S-transferase, C-terminal domain superfamily
IPR040079	Glutathione transferase family

Pfam	Pfam name
PF02798	Glutathione S-transferase, N-terminal domain
PF14497	Glutathione S-transferase, C-terminal domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-156590	Glutathione conjugation	Internal node	R-HSA-1430728	Metabolism
R-HSA-9748787	Azathioprine ADME	Leaf	R-HSA-9748784	Drug ADME
R-HSA-9753281	Paracetamol ADME	Leaf	R-HSA-9748784	Drug ADME

Subcellular location

Location	ECO term	Pubmed
Cytoplasm

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	High	Approved
appendix	lymphoid tissue	High	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Medium	Approved
breast	glandular cells	High	Approved
breast	myoepithelial cells	High	Approved
bronchus	respiratory epithelial cells	High	Approved
caudate	glial cells	Medium	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	High	Approved
cerebellum	cells in granular layer	High	Approved
cerebellum	cells in molecular layer	Low	Approved
cerebral cortex	endothelial cells	Medium	Approved
cerebral cortex	glial cells	Medium	Approved
cerebral cortex	neuronal cells	High	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	High	Approved
colon	endothelial cells	High	Approved
colon	glandular cells	High	Approved
duodenum	glandular cells	High	Approved
endometrium 1	cells in endometrial stroma	High	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	High	Approved
esophagus	squamous epithelial cells	High	Approved
fallopian tube	glandular cells	High	Approved
gallbladder	glandular cells	High	Approved
heart muscle	cardiomyocytes	High	Approved
hippocampus	glial cells	Medium	Approved
hippocampus	neuronal cells	High	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	High	Approved
liver	cholangiocytes	High	Approved
liver	hepatocytes	High	Approved
lung	alveolar cells	Medium	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	High	Approved
lymph node	non-germinal center cells	High	Approved
nasopharynx	respiratory epithelial cells	High	Approved
oral mucosa	squamous epithelial cells	High	Approved
ovary	ovarian stroma cells	Medium	Approved
pancreas	exocrine glandular cells	High	Approved
pancreas	pancreatic endocrine cells	High	Approved
parathyroid gland	glandular cells	High	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	High	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	High	Approved
seminal vesicle	glandular cells	High	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	High	Approved
skin 1	fibroblasts	High	Approved
skin 1	keratinocytes	High	Approved
skin 1	melanocytes	High	Approved
skin 2	epidermal cells	High	Approved
small intestine	glandular cells	High	Approved
smooth muscle	smooth muscle cells	Low	Approved
soft tissue 1	chondrocytes	Medium	Approved
soft tissue 1	fibroblasts	Medium	Approved
soft tissue 1	peripheral nerve	Medium	Approved
soft tissue 2	chondrocytes	Medium	Approved
spleen	cells in red pulp	Medium	Approved
spleen	cells in white pulp	Medium	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	High	Approved
testis	Leydig cells	High	Approved
testis	cells in seminiferous ducts	High	Approved
thyroid gland	glandular cells	High	Approved
tonsil	germinal center cells	High	Approved
tonsil	non-germinal center cells	High	Approved
tonsil	squamous epithelial cells	High	Approved
urinary bladder	urothelial cells	High	Approved
vagina	squamous epithelial cells	High	Approved

Summary of P09488

Gene: GSTM1, GST1
Protein: Glutathione S-transferase Mu 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P09488

Gene: GSTM1, GST1 Protein: Glutathione S-transferase Mu 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: GSTM1, GST1
Protein: Glutathione S-transferase Mu 1