| 1UK0 |
3.0 |
Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor |
| 1UK1 |
3.0 |
Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor |
| 1WOK |
3.0 |
Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase complexed with a quinoxaline-type inhibitor |
| 2COK |
|
Solution structure of BRCT domain of poly(ADP-ribose) polymerase-1 |
| 2CR9 |
|
Solution structure of WGR domain of poly(ADP-ribose) polymerase-1 |
| 2CS2 |
|
Solution structure of the second Zn-finger domain of poly(ADP-ribose) polymerase-1 |
| 2DMJ |
|
Solution structure of the first zf-PARP domain of human Poly(ADP-ribose)polymerase-1 |
| 2JVN |
|
Domain C of human PARP-1 |
| 2L30 |
|
Human PARP-1 zinc finger 1 |
| 2L31 |
|
Human PARP-1 zinc finger 2 |
| 2N8A |
|
1H, 13C and 15N chemical shift assignments and solution structure for PARP-1 F1F2 domains in complex with a DNA single-strand break |
| 2RCW |
2.8 |
PARP complexed with A620223 |
| 2RD6 |
2.3 |
PARP complexed with A861695 |
| 2RIQ |
1.7 |
Crystal Structure of the Third Zinc-binding domain of human PARP-1 |
| 3GJW |
2.3 |
PARP complexed with A968427 |
| 3GN7 |
2.5 |
PARP complexed with A861696 |
| 3L3L |
2.5 |
PARP complexed with A906894 |
| 3L3M |
2.5 |
PARP complexed with A927929 |
| 3OD8 |
2.4 |
Human PARP-1 zinc finger 1 (Zn1) bound to DNA |
| 3ODA |
2.64 |
Human PARP-1 zinc finger 1 (Zn1) bound to DNA |
| 3ODC |
2.8 |
Human PARP-1 zinc finger 2 (Zn2) bound to DNA |
| 3ODE |
2.95 |
Human PARP-1 zinc finger 2 (Zn2) bound to DNA |
| 4AV1 |
3.1 |
Crystal structure of the human PARP-1 DNA binding domain in complex with DNA |
| 4DQY |
3.25 |
Structure of Human PARP-1 bound to a DNA double strand break |
| 4GV7 |
2.89 |
Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328 |
| 4HHY |
2.3637 |
Crystal structure of PARP catalytic domain in complex with novel inhibitors |
| 4HHZ |
2.7199 |
Crystal structure of PARP catalytic domain in complex with novel inhibitors |
| 4L6S |
2.2 |
PARP complexed with benzo[1,4]oxazin-3-one inhibitor |
| 4OPX |
3.314 |
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide |
| 4OQA |
3.65 |
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-(2,4-dihydroxybenzylidene)-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide |
| 4OQB |
3.362 |
Structure of Human PARP-1 bound to a DNA double strand break in complex with (2Z)-2-{4-[2-(morpholin-4-yl)ethoxy]benzylidene}-3-oxo-2,3-dihydro-1-benzofuran-7-carboxamide |
| 4PJT |
2.35 |
Structure of PARP1 catalytic domain bound to inhibitor BMN 673 |
| 4R5W |
2.84 |
Human artd1 (parp1) - catalytic domain in complex with inhibitor xav939 |
| 4R6E |
2.2 |
Human artd1 (parp1) - catalytic domain in complex with inhibitor niraparib |
| 4RV6 |
3.19 |
Human ARTD1 (PARP1) catalytic domain in complex with inhibitor Rucaparib |
| 4UND |
2.2 |
HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR TALAZOPARIB |
| 4UXB |
3.22 |
Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor PJ34 |
| 4XHU |
2.089 |
The complex structure of Timeless_PAB and PARP-1_catalytic domain |
| 4ZZZ |
1.9 |
Structure of human PARP1 catalytic domain bound to an isoindolinone inhibitor |
| 5A00 |
2.75 |
Structure of human PARP1 catalytic domain bound to an isoindolinone inhibitor |
| 5DS3 |
2.6 |
Crystal structure of constitutively active PARP-1 |
| 5HA9 |
4.01 |
Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer |
| 5KPN |
2.3 |
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor |
| 5KPO |
2.65 |
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor |
| 5KPP |
2.33 |
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor |
| 5KPQ |
2.55 |
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor |
| 5WRQ |
2.65 |
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor |
| 5WRY |
2.3 |
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor |
| 5WRZ |
2.2 |
Structure of human PARP1 catalytic domain bound to a phthalazinone inhibitor |
| 5WS0 |
2.6 |
Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor |
| 5WS1 |
1.9 |
Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor |
| 5WTC |
2.2 |
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor |
| 5XSR |
2.3 |
novel orally efficacious inhibitors complexed with PARP1 |
| 5XST |
2.3 |
novel orally efficacious inhibitors complexed with PARP1 |
| 5XSU |
2.4 |
novel orally efficacious inhibitors complexed with PARP1 |
| 6BHV |
2.3 |
Human PARP-1 bound to NAD+ analog benzamide adenine dinucleotide (BAD) |
| 6GHK |
2.28 |
Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527 |
| 6M3I |
1.98 |
Crystal structure of HPF1/PARP1 complex |
| 6NRF |
2.0 |
Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT103 |
| 6NRG |
1.7 |
Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT57 |
| 6NRH |
1.5 |
Crystal Structure of human PARP-1 ART domain bound inhibitor UTT63 |
| 6NRI |
2.2 |
Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT83 |
| 6NRJ |
1.65 |
Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT93 |
| 6NTU |
1.8 |
Crystal Structure of human PARP-1 ART domain bound to inhibitor UKTT-15 |
| 6VKK |
2.1 |
Crystal Structure of human PARP-1 CAT domain bound to inhibitor rucaparib |
| 6VKO |
2.8 |
Crystal Structure of human PARP-1 CAT domain bound to inhibitor UKTT15 |
| 6VKQ |
2.9 |
Crystal Structure of human PARP-1 CAT domain bound to inhibitor EB-47 |
| 6XVW |
2.0 |
Catalytic domain of human PARP-1 in complex with the inhibitor MC2050 |
| 7AAA |
1.74 |
Crystal structure of the catalytic domain of human PARP1 (apo) |
| 7AAB |
2.8 |
Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47 |
| 7AAC |
1.593 |
Crystal structure of the catalytic domain of human PARP1 in complex with veliparib |
| 7AAD |
2.21 |
Crystal structure of the catalytic domain of human PARP1 in complex with olaparib |
| 7CMW |
2.7 |
Complex structure of PARP1 catalytic domain with pamiparib |
| 7KK2 |
1.695 |
Structure of the catalytic domain of PARP1 |
| 7KK3 |
2.06 |
Structure of the catalytic domain of PARP1 in complex with talazoparib |
| 7KK4 |
1.96 |
Structure of the catalytic domain of PARP1 in complex with olaparib |
| 7KK5 |
1.7 |
Structure of the catalytic domain of PARP1 in complex with niraparib |
| 7KK6 |
2.06 |
Structure of the catalytic domain of PARP1 in complex with veliparib |
| 7ONR |
2.05 |
PARP1 catalytic domain in complex with 8-chloroquinazolinone-based inhibitor (compound 9) |
| 7ONS |
1.97 |
PARP1 catalytic domain in complex with isoquinolone-based inhibitor (compound 16) |
| 7ONT |
1.853 |
PARP1 catalytic domain in complex with a selective pyridine carboxamide-based inhibitor (compound 22) |
| 7S68 |
3.3 |
Structure of human PARP1 domains (Zn1, Zn3, WGR and HD) bound to a DNA double strand break. |
| 7S6H |
3.1 |
Human PARP1 deltaV687-E688 bound to NAD+ analog EB-47 and to a DNA double strand break. |
| 7S6M |
3.2 |
Human PARP1 deltaV687-E688 bound to a DNA double strand break. |
| 7S81 |
3.6 |
Structure of human PARP1 domains (Zn1, Zn3, WGR, HD) bound to a DNA double strand break. |
| 7SCY |
4.1 |
Nuc147 bound to single BRCT |
| 7SCZ |
3.5 |
Nuc147 bound to multiple BRCTs |
