Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.13.11.-
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen;
1.13.11.34
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen;
arachidonate 5-lipoxygenase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3O8Y | 2.389 | Stable-5-Lipoxygenase |
| 3V92 | 2.74 | S663A Stable-5-LOX |
| 3V98 | 2.07 | S663D Stable-5-LOX |
| 3V99 | 2.252 | S663D Stable-5-LOX in complex with Arachidonic Acid |
| 6N2W | 2.71 | The structure of Stable-5-Lipoxygenase bound to NDGA |
| 6NCF | 2.871 | The structure of Stable-5-Lipoxygenase bound to AKBA |
| 7TTJ | 2.1 | Stable-5-LOX elongated Ha2 |
| 7TTK | 1.98 | Stable-5-LOX |
| 7TTL | 2.43 | Stable-5-LOX elongated Ha2 (4 copies ASU) |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0036336 | dendritic cell migration |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0006959 | humoral immune response |
| Biological Process | GO:0002232 | leukocyte chemotaxis involved in inflammatory response |
| Biological Process | GO:0002523 | leukocyte migration involved in inflammatory response |
| Biological Process | GO:1901753 | leukotriene A4 biosynthetic process |
| Biological Process | GO:0019370 | leukotriene biosynthetic process |
| Biological Process | GO:0006691 | leukotriene metabolic process |
| Biological Process | GO:0002540 | leukotriene production involved in inflammatory response |
| Biological Process | GO:0043651 | linoleic acid metabolic process |
| Biological Process | GO:0034440 | lipid oxidation |
| Biological Process | GO:2001301 | lipoxin biosynthetic process |
| Biological Process | GO:0019372 | lipoxygenase pathway |
| Biological Process | GO:0042759 | long-chain fatty acid biosynthetic process |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:1903573 | negative regulation of response to endoplasmic reticulum stress |
| Biological Process | GO:1903671 | negative regulation of sprouting angiogenesis |
| Biological Process | GO:0061044 | negative regulation of vascular wound healing |
| Biological Process | GO:0061045 | negative regulation of wound healing |
| Biological Process | GO:0030501 | positive regulation of bone mineralization |
| Biological Process | GO:1904999 | positive regulation of leukocyte adhesion to arterial endothelial cell |
| Biological Process | GO:1900407 | regulation of cellular response to oxidative stress |
| Biological Process | GO:1900015 | regulation of cytokine production involved in inflammatory response |
| Biological Process | GO:0045598 | regulation of fat cell differentiation |
| Biological Process | GO:0050727 | regulation of inflammatory response |
| Biological Process | GO:0106014 | regulation of inflammatory response to wounding |
| Biological Process | GO:0050796 | regulation of insulin secretion |
| Biological Process | GO:1903426 | regulation of reactive oxygen species biosynthetic process |
| Molecular Function | GO:0004052 | arachidonate 12(S)-lipoxygenase activity |
| Molecular Function | GO:0004051 | arachidonate 5-lipoxygenase activity |
| Molecular Function | GO:0036403 | arachidonate 8(S)-lipoxygenase activity |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005641 | nuclear envelope lumen |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0034774 | secretory granule lumen |
| InterPro
|
InterPro name |
|---|---|
| IPR000907 | Lipoxygenase |
| IPR001024 | PLAT/LH2 domain |
| IPR001885 | Lipoxygenase, mammalian |
| IPR013819 | Lipoxygenase, C-terminal |
| IPR020833 | Lipoxygenase, iron binding site |
| IPR020834 | Lipoxygenase, conserved site |
| IPR036226 | Lipoxigenase, C-terminal domain superfamily |
| IPR036392 | PLAT/LH2 domain superfamily |
| IPR042062 | Lipoxygenase, vertebrates, PLAT domain |
| Pfam
|
Pfam name |
|---|---|
| PF00305 | Lipoxygenase |
| PF01477 | PLAT/LH2 domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2142688 | Synthesis of 5-eicosatetraenoic acids | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2142700 | Synthesis of Lipoxins (LX) | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-9012546 | Interleukin-18 signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-9018676 | Biosynthesis of D-series resolvins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9018682 | Biosynthesis of maresins | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9020265 | Biosynthesis of aspirin-triggered D-series resolvins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9023661 | Biosynthesis of E-series 18(R)-resolvins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9026286 | Biosynthesis of DPAn-3-derived protectins and resolvins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9026290 | Biosynthesis of DPAn-3-derived maresins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9026403 | Biosynthesis of DPAn-3-derived 13-series resolvins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9027604 | Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000250 | PubMed:18978352 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:19233132 |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:19022417 |
| Nucleus envelope | ECO:0000269 | PubMed:16275640 |
| Nucleus envelope | ECO:0000269 | PubMed:19233132 |
| Nucleus envelope | ECO:0000269 | PubMed:8245774 |
| Nucleus intermembrane space | ECO:0000269 | PubMed:8245774 |
| Nucleus matrix | ECO:0000269 | PubMed:19233132 |
| Nucleus membrane | ECO:0000269 | PubMed:16275640 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0001426 | Multifactorial inheritance |
| HP:0002099 | Asthma |
| HP:0032933 | Airway hyperresponsiveness |
| HP:4000007 | Bronchoconstriction |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| appendix | germinal center cells | Medium | Enhanced |
| appendix | non-germinal center cells | Medium | Enhanced |
| bone marrow | hematopoietic cells | Medium | Enhanced |
| caudate | glial cells | High | Enhanced |
| cerebellum | granular cells - nucleus | Medium | Enhanced |
| cerebellum | molecular layer cells - nucleus | High | Enhanced |
| cerebellum | processes in molecular layer | High | Enhanced |
| cerebellum | white matter cells - nucleus | High | Enhanced |
| cerebral cortex | glial cells | High | Enhanced |
| colon | mucosal lymphoid cells | Medium | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| hippocampus | glial cells | High | Enhanced |
| lung | alveolar cells type II | Medium | Enhanced |
| lung | macrophages | High | Enhanced |
| lymph node | germinal center cells | High | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| pancreas | pancreatic endocrine cells | Medium | Enhanced |
| rectum | mucosal lymphoid cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Low | Enhanced |
| skin 1 | fibrohistiocytic cells | Medium | Enhanced |
| skin 1 | langerhans cells | High | Enhanced |
| skin 1 | lymphocytes | High | Enhanced |
| skin 2 | fibrohistiocytic cells | High | Enhanced |
| skin 2 | langerhans cells | High | Enhanced |
| skin 2 | lymphocytes | High | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| spleen | cells in white pulp | High | Enhanced |
| tonsil | germinal center cells | Low | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Low | Enhanced |
| urinary bladder | urothelial cells | High | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|