MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
4J8F	2.7	Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain of Hip
6FDT		NMR structure of the second TPR domain of the human RPAP3 protein in complex with HSP70 peptide SGPTIEEVD
7F4X	1.6	Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP
7F4Z	1.8	X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with ADP
7F50	1.703	X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with AMPPnP

GO term

GO ontology	GO term	GO description
Biological Process	GO:0046034	ATP metabolic process
Biological Process	GO:0070370	cellular heat acclimation
Biological Process	GO:0034605	cellular response to heat
Biological Process	GO:0034599	cellular response to oxidative stress
Biological Process	GO:0071383	cellular response to steroid hormone stimulus
Biological Process	GO:0051085	chaperone cofactor-dependent protein refolding
Biological Process	GO:0006402	mRNA catabolic process
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0060548	negative regulation of cell death
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process	GO:0090084	negative regulation of inclusion body assembly
Biological Process	GO:0031397	negative regulation of protein ubiquitination
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0032757	positive regulation of interleukin-8 production
Biological Process	GO:0090063	positive regulation of microtubule nucleation
Biological Process	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway
Biological Process	GO:0042026	protein refolding
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:1901673	regulation of mitotic spindle assembly
Biological Process	GO:0031396	regulation of protein ubiquitination
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140545	ATP-dependent protein disaggregase activity
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone
Molecular Function	GO:0055131	C3HC4-type RING finger domain binding
Molecular Function	GO:0001664	G protein-coupled receptor binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0031072	heat shock protein binding
Molecular Function	GO:0042826	histone deacetylase binding
Molecular Function	GO:0044183	protein folding chaperone
Molecular Function	GO:0005102	signaling receptor binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0051082	unfolded protein binding
Molecular Function	GO:0001618	virus receptor activity
Cellular Component	GO:0016235	aggresome
Cellular Component	GO:0072562	blood microparticle
Cellular Component	GO:0005814	centriole
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0016234	inclusion body
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:1990904	ribonucleoprotein complex
Cellular Component	GO:0031982	vesicle

InterPro / Pfam

InterPro	InterPro name
IPR013126	Heat shock protein 70 family
IPR018181	Heat shock protein 70, conserved site
IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily
IPR029048	Heat shock protein 70kD, C-terminal domain superfamily
IPR043129	ATPase, nucleotide binding domain

Pfam	Pfam name
PF00012	Hsp70 protein

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3371568	Attenuation phase	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-3371571	HSF1-dependent transactivation	Internal node	R-HSA-8953897	Cellular responses to stimuli
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:17289661
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	ECO:0000269	PubMed:27137183

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Approved
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Low	Approved
breast	glandular cells	Low	Approved
bronchus	respiratory epithelial cells	High	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	High	Approved
cerebellum	Purkinje cells	Low	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	neuronal cells	Medium	Approved
cervix	glandular cells	High	Approved
cervix	squamous epithelial cells	High	Approved
colon	endothelial cells	Low	Approved
colon	glandular cells	Low	Approved
colon	peripheral nerve/ganglion	Low	Approved
duodenum	glandular cells	Low	Approved
endometrium 1	glandular cells	Low	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	High	Approved
esophagus	squamous epithelial cells	High	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	High	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in glomeruli	Medium	Approved
liver	cholangiocytes	Medium	Approved
liver	hepatocytes	Low	Approved
lung	macrophages	Low	Approved
lymph node	non-germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	High	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
ovary	ovarian stroma cells	Medium	Approved
pancreas	pancreatic endocrine cells	Low	Approved
parathyroid gland	glandular cells	Low	Approved
placenta	trophoblastic cells	Low	Approved
prostate	glandular cells	High	Approved
rectum	glandular cells	Low	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	High	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	High	Approved
skin 1	keratinocytes	High	Approved
skin 1	melanocytes	High	Approved
skin 2	epidermal cells	High	Approved
small intestine	glandular cells	Low	Approved
smooth muscle	smooth muscle cells	Medium	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Medium	Approved
testis	elongated or late spermatids	High	Approved
testis	pachytene spermatocytes	High	Approved
testis	preleptotene spermatocytes	Low	Approved
testis	round or early spermatids	High	Approved
testis	spermatogonia cells	Low	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	non-germinal center cells	Low	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	High	Approved
vagina	squamous epithelial cells	Medium	Approved

Disease

Summary of P0DMV9

Gene: HSPA1B, HSP72
Protein: Heat shock 70 kDa protein 1B

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P0DMV9

Gene: HSPA1B, HSP72 Protein: Heat shock 70 kDa protein 1B

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: HSPA1B, HSP72
Protein: Heat shock 70 kDa protein 1B