MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.1.56	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; methylumbelliferyl-acetate deacetylase
3.1.2.12	Hydrolases; Acting on ester bonds; Thioester hydrolases; S-formylglutathione hydrolase

Structure

PDB	Resolution (Å)	PDB name
3FCX	1.5	Crystal structure of human esterase D

GO term

GO ontology	GO term	GO description
Biological Process	GO:0046294	formaldehyde catabolic process
Molecular Function	GO:0018738	S-formylglutathione hydrolase activity
Molecular Function	GO:0052689	carboxylic ester hydrolase activity
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0047374	methylumbelliferyl-acetate deacetylase activity
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0070062	extracellular exosome

InterPro	InterPro name
IPR000801	Esterase-like
IPR014186	S-formylglutathione hydrolase
IPR029058	Alpha/Beta hydrolase fold

Pfam	Pfam name
PF00756	Putative esterase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-156590	Glutathione conjugation	Internal node	R-HSA-1430728	Metabolism

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	High	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	glandular cells	Low	Approved
breast	myoepithelial cells	Low	Approved
bronchus	respiratory epithelial cells	High	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	Low	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebellum	cells in molecular layer	Medium	Approved
cerebral cortex	glial cells	Medium	Approved
cerebral cortex	neuronal cells	Medium	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	High	Approved
colon	glandular cells	High	Approved
colon	peripheral nerve/ganglion	High	Approved
duodenum	glandular cells	High	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	High	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in tubules	Medium	Approved
liver	hepatocytes	Low	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	Low	Approved
nasopharynx	respiratory epithelial cells	High	Approved
pancreas	exocrine glandular cells	Low	Approved
pancreas	pancreatic endocrine cells	High	Approved
prostate	glandular cells	High	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Medium	Approved
skin 1	melanocytes	Low	Approved
small intestine	glandular cells	High	Approved
smooth muscle	smooth muscle cells	Low	Approved
soft tissue 1	fibroblasts	Low	Approved
soft tissue 2	chondrocytes	Medium	Approved
soft tissue 2	fibroblasts	Low	Approved
spleen	cells in red pulp	Medium	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	High	Approved
testis	Leydig cells	Medium	Approved
testis	spermatogonia cells	High	Approved
thyroid gland	glandular cells	High	Approved
urinary bladder	urothelial cells	Medium	Approved

Location	ECO term	Pubmed
Cytoplasm
Cytoplasmic vesicle

Summary of P10768

Gene: ESD
Protein: S-formylglutathione hydrolase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P10768

Gene: ESD Protein: S-formylglutathione hydrolase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ESD
Protein: S-formylglutathione hydrolase