MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.1.3	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; triacylglycerol lipase
3.1.1.32	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; phospholipase A1
3.1.1.5	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; lysophospholipase

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0034382	chylomicron remnant clearance
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0034375	high-density lipoprotein particle remodeling
Biological Process	GO:0034373	intermediate-density lipoprotein particle remodeling
Biological Process	GO:0016042	lipid catabolic process
Biological Process	GO:0034374	low-density lipoprotein particle remodeling
Biological Process	GO:0034638	phosphatidylcholine catabolic process
Biological Process	GO:0043691	reverse cholesterol transport
Biological Process	GO:0019433	triglyceride catabolic process
Biological Process	GO:0070328	triglyceride homeostasis
Biological Process	GO:0034372	very-low-density lipoprotein particle remodeling
Molecular Function	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Molecular Function	GO:0034185	apolipoprotein binding
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0016298	lipase activity
Molecular Function	GO:0030169	low-density lipoprotein particle binding
Molecular Function	GO:0004622	lysophospholipase activity
Molecular Function	GO:0102545	phosphatidyl phospholipase B activity
Molecular Function	GO:0052739	phosphatidylserine 1-acylhydrolase activity
Molecular Function	GO:0008970	phospholipase A1 activity
Molecular Function	GO:0004620	phospholipase activity
Molecular Function	GO:0004806	triglyceride lipase activity
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0034364	high-density lipoprotein particle

InterPro / Pfam

InterPro	InterPro name
IPR000734	Triacylglycerol lipase family
IPR001024	PLAT/LH2 domain
IPR002333	Hepatic lipase
IPR013818	Lipase
IPR016272	Lipase, LIPH-type
IPR029058	Alpha/Beta hydrolase fold
IPR033906	Lipase, N-terminal
IPR036392	PLAT/LH2 domain superfamily

Pfam	Pfam name
PF00151	Lipase
PF01477	PLAT/LH2 domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-8963889	Assembly of active LPL and LIPC lipase complexes	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-8964026	Chylomicron clearance	Leaf	R-HSA-382551	Transport of small molecules

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000855	Insulin resistance
HP:0001013	Eruptive xanthomas
HP:0001084	Corneal arcus
HP:0001681	Angina pectoris
HP:0002155	Hypertriglyceridemia
HP:0003124	Hypercholesterolemia
HP:0003584	Late onset
HP:0005181	Premature coronary artery atherosclerosis
HP:0005978	Type II diabetes mellitus
HP:0012184	Increased HDL cholesterol concentration
HP:0031819	Increased waist to hip ratio

Summary of P11150

Gene: LIPC, HTGL
Protein: Hepatic triacylglycerol lipase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P11150

Gene: LIPC, HTGL Protein: Hepatic triacylglycerol lipase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: LIPC, HTGL
Protein: Hepatic triacylglycerol lipase