MultifacetedProtDB - Bologna Biocomputing Group

Summary of P11712

Gene: CYP2C9, CYP2C10
Protein: Cytochrome P450 2C9

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
1.14.14.1	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor; unspecific monooxygenase
1.14.14.51	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor; (S)-limonene 6-monooxygenase
1.14.14.52	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor; (S)-limonene 7-monooxygenase
1.14.14.53	Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor; (R)-limonene 6-monooxygenase

Publications

Structure

Link to AlphaFold model

PDB	Resolution (Å)	PDB name
1OG2	2.6	Structure of human cytochrome P450 CYP2C9
1OG5	2.55	Structure of human cytochrome P450 CYP2C9
1R9O	2.0	Crystal Structure of P4502C9 with Flurbiprofen bound
4NZ2	2.45	Crystal structure of CYP2C9 in complex with an inhibitor
5A5I	2.0	Cytochrome 2C9 P450 inhibitor complex
5A5J	2.9	Cytochrome 2C9 P450 inhibitor complex
5K7K	2.3	Design and Optimization of Biaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7: Discovery of Clinical Candidate PF-05089771
5W0C	2.001	Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex
5X23	2.0	Crystal structure of CYP2C9 genetic variant A477T (*30) in complex with multiple losartan molecules
5X24	2.48	Crystal structure of CYP2C9 genetic variant I359L (*3) in complex with multiple losartan molecules
5XXI	2.3	Crystal structure of CYP2C9 in complex with multiple losartan molecules
6VLT	3.12	Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
7RL2	2.23	Crystal Structure of the Human Cytochrome P450 2C98 (CYP2C98) Genetic Variant in Complex with the Drug Losartan

GO term

GO ontology	GO term	GO description
Biological Process	GO:0043603	amide metabolic process
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0019373	epoxygenase P450 pathway
Biological Process	GO:0008210	estrogen metabolic process
Biological Process	GO:0046456	icosanoid biosynthetic process
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process
Biological Process	GO:0032787	monocarboxylic acid metabolic process
Biological Process	GO:0016098	monoterpenoid metabolic process
Biological Process	GO:0097267	omega-hydroxylase P450 pathway
Biological Process	GO:0070989	oxidative demethylation
Biological Process	GO:0008202	steroid metabolic process
Biological Process	GO:0019627	urea metabolic process
Biological Process	GO:0042178	xenobiotic catabolic process
Biological Process	GO:0006805	xenobiotic metabolic process
Molecular Function	GO:0052741	(R)-limonene 6-monooxygenase activity
Molecular Function	GO:0018675	(S)-limonene 6-monooxygenase activity
Molecular Function	GO:0018676	(S)-limonene 7-monooxygenase activity
Molecular Function	GO:0008405	arachidonic acid 11,12-epoxygenase activity
Molecular Function	GO:0008404	arachidonic acid 14,15-epoxygenase activity
Molecular Function	GO:0008392	arachidonic acid epoxygenase activity
Molecular Function	GO:0070330	aromatase activity
Molecular Function	GO:0034875	caffeine oxidase activity
Molecular Function	GO:0020037	heme binding
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0004497	monooxygenase activity
Molecular Function	GO:0016491	oxidoreductase activity
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Molecular Function	GO:0008395	steroid hydroxylase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0043231	intracellular membrane-bounded organelle
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR001128	Cytochrome P450
IPR002401	Cytochrome P450, E-class, group I
IPR017972	Cytochrome P450, conserved site
IPR036396	Cytochrome P450 superfamily

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-211981	Xenobiotics	Internal node	R-HSA-1430728	Metabolism
R-HSA-211999	CYP2E1 reactions	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Leaf	R-HSA-1430728	Metabolism
R-HSA-9027307	Biosynthesis of maresin-like SPMs	Leaf	R-HSA-1430728	Metabolism
R-HSA-9749641	Aspirin ADME	Leaf	R-HSA-9748784	Drug ADME

Location	ECO term	Pubmed
Endoplasmic reticulum membrane
Microsome membrane	ECO:0000269	PubMed:21576599

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0001871	Abnormality of blood and blood-forming tissues

Tissue	Cell type	Expression level	Reliability
colon	enterocytes	Low	Enhanced
duodenum	glandular cells	Medium	Enhanced
gallbladder	glandular cells	Low	Enhanced
liver	hepatocytes	High	Enhanced
small intestine	enterocytes	Low	Enhanced
stomach 1	glandular cells	Low	Enhanced
stomach 2	glandular cells	Low	Enhanced

Summary of P11712

Gene: CYP2C9, CYP2C10
Protein: Cytochrome P450 2C9

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P11712

Gene: CYP2C9, CYP2C10 Protein: Cytochrome P450 2C9

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CYP2C9, CYP2C10
Protein: Cytochrome P450 2C9