Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.1.1.-
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
1.1.1.1
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
alcohol dehydrogenase
1.1.1.284
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
S-(hydroxymethyl)glutathione dehydrogenase
PDB | Resolution (Å) | PDB name |
---|---|---|
1M6H | 2.0 | Human glutathione-dependent formaldehyde dehydrogenase |
1M6W | 2.3 | Binary complex of Human glutathione-dependent formaldehyde dehydrogenase and 12-Hydroxydodecanoic acid |
1MA0 | 2.3 | Ternary complex of Human glutathione-dependent formaldehyde dehydrogenase with NAD+ and dodecanoic acid |
1MC5 | 2.6 | Ternary complex of Human glutathione-dependent formaldehyde dehydrogenase with S-(hydroxymethyl)glutathione and NADH |
1MP0 | 2.2 | Binary Complex of Human Glutathione-Dependent Formaldehyde Dehydrogenase with NAD(H) |
1TEH | 2.7 | STRUCTURE OF HUMAN LIVER CHICHI ALCOHOL DEHYDROGENASE (A GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE) |
2FZE | 1.9 | Crystal structure of the binary complex of human glutathione-dependent formaldehyde dehydrogenase with ADP-ribose |
2FZW | 1.84 | Structure of the binary complex of the E67L mutant of human glutathione-dependent formaldehyde dehydrogenase with NAD(H) |
3QJ5 | 1.9 | S-nitrosoglutathione reductase (GSNOR) in complex with N6022 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006069 | ethanol oxidation |
Biological Process | GO:0010430 | fatty acid omega-oxidation |
Biological Process | GO:0046294 | formaldehyde catabolic process |
Biological Process | GO:0018119 | peptidyl-cysteine S-nitrosylation |
Biological Process | GO:0045777 | positive regulation of blood pressure |
Biological Process | GO:0003016 | respiratory system process |
Biological Process | GO:0032496 | response to lipopolysaccharide |
Biological Process | GO:0051409 | response to nitrosative stress |
Biological Process | GO:0051775 | response to redox state |
Biological Process | GO:0001523 | retinoid metabolic process |
Molecular Function | GO:0106322 | S-(hydroxymethyl)glutathione dehydrogenase NAD activity |
Molecular Function | GO:0106321 | S-(hydroxymethyl)glutathione dehydrogenase NADP activity |
Molecular Function | GO:0051903 | S-(hydroxymethyl)glutathione dehydrogenase activity |
Molecular Function | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent |
Molecular Function | GO:0009055 | electron transfer activity |
Molecular Function | GO:0005504 | fatty acid binding |
Molecular Function | GO:0018467 | formaldehyde dehydrogenase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0008270 | zinc ion binding |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005739 | mitochondrion |
InterPro | InterPro name |
---|---|
IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
IPR011032 | GroES-like superfamily |
IPR013149 | Alcohol dehydrogenase-like, C-terminal |
IPR013154 | Alcohol dehydrogenase-like, N-terminal |
IPR014183 | Alcohol dehydrogenase class III |
IPR036291 | NAD(P)-binding domain superfamily |
Pfam | Pfam name |
---|---|
PF00107 | Zinc-binding dehydrogenase |
PF08240 | Alcohol dehydrogenase GroES-like domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-71384 | Ethanol oxidation | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000305 |
HPO ID | HPO name |
---|---|
HP:0000013 | Hypoplasia of the uterus |
HP:0000252 | Microcephaly |
HP:0000268 | Dolichocephaly |
HP:0000506 | Telecanthus |
HP:0000729 | Autistic behavior |
HP:0000835 | Adrenal hypoplasia |
HP:0000953 | Hyperpigmentation of the skin |
HP:0001249 | Intellectual disability |
HP:0001508 | Failure to thrive |
HP:0001873 | Thrombocytopenia |
HP:0001882 | Leukopenia |
HP:0001903 | Anemia |
HP:0002863 | Myelodysplasia |
HP:0004322 | Short stature |
HP:0004808 | Acute myeloid leukemia |
HP:0005301 | Persistent left superior vena cava |
HP:0005528 | Bone marrow hypocellularity |
HP:0007018 | Attention deficit hyperactivity disorder |
HP:0010984 | Digenic inheritance |
HP:0032524 | Long thumb |
HP:0033044 | Motor regression |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
amed syndrome- digenic | MONDO:0030894 | D61 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIM:619151 | Orphanet:611216 |