MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.1.1.205	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; IMP dehydrogenase

Structure

PDB	Resolution (Å)	PDB name
1B3O	2.9	TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE
1NF7	2.65	Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide
1NFB	2.9	Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD
6I0M	2.567	Structure of human IMP dehydrogenase, isoform 2, bound to GDP
6I0O	2.623	Structure of human IMP dehydrogenase, isoform 2, bound to GTP
6U8E	3.03	Human IMPDH2 treated with ATP, IMP, and NAD+. Filament assembly interface reconstruction.
6U8N	3.29	Human IMPDH2 treated with ATP, IMP, and NAD+. Fully extended filament segment reconstruction.
6U8R	3.91	Human IMPDH2 treated with ATP, IMP, and NAD+. Bent (1/4 compressed, 3/4 extended) segment reconstruction.
6U8S	3.14	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Filament assembly interface reconstruction.
6U9O	3.36	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Fully compressed filament segment reconstruction.
6UA2	4.2	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (2/4 compressed, 2/4 extended) segment reconstruction.
6UA4	3.65	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (3/4 compressed, 1/4 extended) segment reconstruction.
6UA5	3.79	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free interfacial octamer reconstruction.
6UAJ	3.84	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction.
6UC2	4.48	Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction.
6UDO	3.21	Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament segment reconstruction.
6UDP	2.95	Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Filament assembly interface reconstruction.
6UDQ	3.27	Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament end reconstruction.

GO term

GO ontology	GO term	GO description
Biological Process	GO:0097294	'de novo' XMP biosynthetic process
Biological Process	GO:0006177	GMP biosynthetic process
Biological Process	GO:0006183	GTP biosynthetic process
Biological Process	GO:0071353	cellular response to interleukin-4
Biological Process	GO:0007623	circadian rhythm
Biological Process	GO:0046651	lymphocyte proliferation
Biological Process	GO:0060041	retina development in camera-type eye
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003938	IMP dehydrogenase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0000166	nucleotide binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005778	peroxisomal membrane
Cellular Component	GO:0034774	secretory granule lumen

InterPro / Pfam

InterPro	InterPro name
IPR000644	CBS domain
IPR001093	IMP dehydrogenase/GMP reductase
IPR005990	Inosine-5'-monophosphate dehydrogenase
IPR013785	Aldolase-type TIM barrel
IPR015875	IMP dehydrogenase / GMP reductase, conserved site

Pfam	Pfam name
PF00478	IMP dehydrogenase / GMP reductase domain
PF00571	CBS domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	Leaf	R-HSA-1430728	Metabolism
R-HSA-9679191	Potential therapeutics for SARS	Leaf	R-HSA-1643685	Disease
R-HSA-9748787	Azathioprine ADME	Leaf	R-HSA-9748784	Drug ADME

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:14766016
Cytoplasm, cytosol	ECO:0000269	PubMed:31337707
Nucleus	ECO:0000269	PubMed:14766016

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000365	Hearing impairment
HP:0000473	Torticollis
HP:0000666	Horizontal nystagmus
HP:0000716	Depression
HP:0000722	Compulsive behaviors
HP:0000739	Anxiety
HP:0000821	Hypothyroidism
HP:0000822	Hypertension
HP:0001249	Intellectual disability
HP:0001251	Ataxia
HP:0001300	Parkinsonism
HP:0001348	Brisk reflexes
HP:0001370	Rheumatoid arthritis
HP:0001761	Pes cavus
HP:0001762	Talipes equinovarus
HP:0002063	Rigidity
HP:0002066	Gait ataxia
HP:0002067	Bradykinesia
HP:0002071	Abnormality of extrapyramidal motor function
HP:0002166	Impaired vibration sensation in the lower limbs
HP:0002174	Postural tremor
HP:0002360	Sleep disturbance
HP:0002395	Lower limb hyperreflexia
HP:0002451	Limb dystonia
HP:0002601	Paresis of extensor muscles of the big toe
HP:0002650	Scoliosis
HP:0003487	Babinski sign
HP:0003785	Decreased CSF homovanillic acid concentration
HP:0004373	Focal dystonia
HP:0005876	Progressive flexion contractures
HP:0007325	Generalized dystonia
HP:0008297	Transient hyperphenylalaninemia
HP:0012378	Fatigue
HP:0045007	Abnormal substantia nigra morphology

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Approved
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	High	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	High	Approved
breast	adipocytes	Medium	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	cells in granular layer	Low	Approved
cerebellum	cells in molecular layer	Medium	Approved
cerebral cortex	endothelial cells	Medium	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuronal cells	Medium	Approved
cervix	glandular cells	Low	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	High	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	cells in endometrial stroma	Medium	Approved
endometrium 2	glandular cells	Medium	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	High	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	glial cells	Low	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in glomeruli	Low	Approved
kidney	cells in tubules	Medium	Approved
liver	cholangiocytes	Medium	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Low	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	High	Approved
lymph node	non-germinal center cells	Medium	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
ovary	follicle cells	Low	Approved
ovary	ovarian stroma cells	Medium	Approved
pancreas	exocrine glandular cells	High	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	Low	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Low	Approved
skin 1	fibroblasts	Low	Approved
skin 1	keratinocytes	Low	Approved
skin 1	melanocytes	Low	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	High	Approved
smooth muscle	smooth muscle cells	Low	Approved
soft tissue 1	fibroblasts	Low	Approved
soft tissue 2	fibroblasts	Low	Approved
soft tissue 2	peripheral nerve	Low	Approved
spleen	cells in red pulp	Low	Approved
spleen	cells in white pulp	Medium	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	High	Approved
testis	pachytene spermatocytes	Low	Approved
testis	spermatogonia cells	High	Approved
thyroid gland	glandular cells	High	Approved
tonsil	germinal center cells	High	Approved
tonsil	non-germinal center cells	High	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	Medium	Approved

Summary of P12268

Gene: IMPDH2, IMPD2
Protein: Inosine-5'-monophosphate dehydrogenase 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P12268

Gene: IMPDH2, IMPD2 Protein: Inosine-5'-monophosphate dehydrogenase 2

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: IMPDH2, IMPD2
Protein: Inosine-5'-monophosphate dehydrogenase 2