MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1O6S	1.8	Internalin (Listeria monocytogenes) / E-Cadherin (human) Recognition Complex
2O72	2.0	Crystal Structure Analysis of human E-cadherin (1-213)
2OMT	2.0	Crystal structure of InlA G194S+S/hEC1 complex
2OMU	1.8	Crystal structure of InlA G194S+S Y369S/hEC1 complex
2OMV	1.9	Crystal structure of InlA S192N Y369S/hEC1 complex
2OMX	1.7	Crystal structure of InlA S192N G194S+S/hEC1 complex
2OMY	1.7	Crystal structure of InlA S192N/hEC1 complex
2OMZ	1.6	Crystal structure of InlA Y369A/hEC1 complex
3FF7	1.8	Structure of NK cell receptor KLRG1 bound to E-cadherin
3FF8	2.0	Structure of NK cell receptor KLRG1 bound to E-cadherin
3L6X	2.4	Crystal structure of p120 catenin in complex with E-cadherin
3L6Y	3.0	Crystal structure of p120 catenin in complex with E-cadherin
4ZT1	1.92	Crystal structure of human E-Cadherin (residues 3-213) in x-dimer conformation
4ZTE	2.13	Crystal structure of human E-Cadherin (residues 3-213) in complex with a peptidomimetic inhibitor
6CXY	2.2	Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11
6OLE	3.1	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs
6OLF	3.9	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs
6OLG	3.4	Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
6VEL	2.65	Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody 66E8Fab
7STZ	2.95	Crystal Structure of Human E-cadherin EC1-5 bound by mouse monoclonal antibody Fab mAb-1_19A11

GO term

GO ontology	GO term	GO description
Biological Process	GO:0034332	adherens junction organization
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Process	GO:0000902	cell morphogenesis
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0044331	cell-cell adhesion mediated by cadherin
Biological Process	GO:0007043	cell-cell junction assembly
Biological Process	GO:0071681	cellular response to indole-3-methanol
Biological Process	GO:0071285	cellular response to lithium ion
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
Biological Process	GO:0030517	negative regulation of axon extension
Biological Process	GO:0030336	negative regulation of cell migration
Biological Process	GO:0022408	negative regulation of cell-cell adhesion
Biological Process	GO:0031175	neuron projection development
Biological Process	GO:0021983	pituitary gland development
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0042307	positive regulation of protein import into nucleus
Biological Process	GO:0072659	protein localization to plasma membrane
Biological Process	GO:0010468	regulation of gene expression
Biological Process	GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission
Biological Process	GO:0140459	response to Gram-positive bacterium
Biological Process	GO:0009636	response to toxic substance
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0007416	synapse assembly
Molecular Function	GO:0032794	GTPase activating protein binding
Molecular Function	GO:0030506	ankyrin binding
Molecular Function	GO:0008013	beta-catenin binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0050839	cell adhesion molecule binding
Molecular Function	GO:0045295	gamma-catenin binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:1990782	protein tyrosine kinase binding
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0043296	apical junction complex
Cellular Component	GO:0016342	catenin complex
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0016600	flotillin complex
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0016328	lateral plasma membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098794	postsynapse
Cellular Component	GO:0005802	trans-Golgi network

InterPro / Pfam

InterPro	InterPro name
IPR000233	Cadherin, Y-type LIR-motif
IPR002126	Cadherin-like
IPR014868	Cadherin prodomain
IPR015919	Cadherin-like superfamily
IPR020894	Cadherin conserved site
IPR027397	Catenin binding domain superfamily
IPR039808	Cadherin

Pfam	Pfam name
PF00028	Cadherin domain
PF01049	Cadherin, Y-type LIR-motif
PF08758	Cadherin prodomain like

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1474228	Degradation of the extracellular matrix	Internal node	R-HSA-1474244	Extracellular matrix organization
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Leaf	R-HSA-168256	Immune System
R-HSA-216083	Integrin cell surface interactions	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-418990	Adherens junctions interactions	Internal node	R-HSA-1500931	Cell-Cell communication
R-HSA-5626467	RHO GTPases activate IQGAPs	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cell junction, adherens junction	ECO:0000269	PubMed:28169360
Cell membrane	ECO:0000269	PubMed:19403558
Cell membrane	ECO:0000269	PubMed:28301459
Endosome
Golgi apparatus, trans-Golgi network

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000175	Cleft palate
HP:0000202	Orofacial cleft
HP:0000204	Cleft upper lip
HP:0000220	Velopharyngeal insufficiency
HP:0000316	Hypertelorism
HP:0000327	Hypoplasia of the maxilla
HP:0000348	High forehead
HP:0000403	Recurrent otitis media
HP:0000405	Conductive hearing impairment
HP:0000453	Choanal atresia
HP:0000478	Abnormality of the eye
HP:0000492	Abnormal eyelid morphology
HP:0000504	Abnormality of vision
HP:0000668	Hypodontia
HP:0000670	Carious teeth
HP:0000689	Dental malocclusion
HP:0000698	Conical tooth
HP:0000750	Delayed speech and language development
HP:0001428	Somatic mutation
HP:0001611	Hypernasal speech
HP:0001792	Small nail
HP:0002023	Anal atresia
HP:0002033	Poor suck
HP:0002164	Nail dysplasia
HP:0002582	Atrophic gastritis
HP:0002744	Bilateral cleft lip and palate
HP:0003002	Breast carcinoma
HP:0003581	Adult onset
HP:0004395	Malnutrition
HP:0004471	Aplasia cutis congenita over the scalp vertex
HP:0006101	Finger syndactyly
HP:0006292	Abnormality of dental eruption
HP:0006342	Peg-shaped maxillary lateral incisors
HP:0006774	Ovarian papillary adenocarcinoma
HP:0007651	Ectropion of lower eyelids
HP:0008070	Sparse hair
HP:0008872	Feeding difficulties in infancy
HP:0009088	Speech articulation difficulties
HP:0009743	Distichiasis
HP:0009890	High anterior hairline
HP:0010294	Palate fistula
HP:0011044	Abnormal number of permanent teeth
HP:0011362	Abnormal hair quantity
HP:0012114	Endometrial carcinoma
HP:0012125	Prostate cancer
HP:0012126	Stomach cancer
HP:0012368	Flat face
HP:0012725	Cutaneous syndactyly
HP:0012905	Euryblepharon
HP:0030001	Lagophthalmos
HP:0030084	Clinodactyly
HP:0045005	Neural tube defect
HP:0100334	Unilateral cleft palate
HP:0100337	Bilateral cleft palate
HP:0100621	Dysgerminoma
HP:0200040	Epidermoid cyst
HP:0200136	Oral-pharyngeal dysphagia
HP:0200153	Agenesis of lateral incisor

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
appendix	endocrine cells	Medium	Enhanced
appendix	enterocytes	Medium	Enhanced
appendix	enterocytes - Microvilli	Medium	Enhanced
appendix	goblet cells	Medium	Enhanced
breast	glandular cells	High	Enhanced
breast	myoepithelial cells	Medium	Enhanced
bronchus	basal cells	Medium	Enhanced
bronchus	ciliated cells (cell body)	Medium	Enhanced
bronchus	ciliated cells (ciliary rootlets)	High	Enhanced
bronchus	goblet cells	Medium	Enhanced
cervix	glandular cells	Medium	Enhanced
cervix	squamous epithelial cells	High	Enhanced
colon	endocrine cells	High	Enhanced
colon	enterocytes	High	Enhanced
colon	enterocytes - Microvilli	High	Enhanced
colon	goblet cells	High	Enhanced
duodenum	endocrine cells	Medium	Enhanced
duodenum	enterocytes	Medium	Enhanced
duodenum	enterocytes - Microvilli	Low	Enhanced
duodenum	glands of Brunner	High	Enhanced
duodenum	goblet cells	Medium	Enhanced
duodenum	paneth cells	Medium	Enhanced
endometrium 1	glandular cells	High	Enhanced
endometrium 2	glandular cells	High	Enhanced
epididymis	glandular cells	High	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
fallopian tube	ciliated cells (cell body)	Low	Enhanced
fallopian tube	ciliated cells (ciliary rootlets)	High	Enhanced
gallbladder	glandular cells	High	Enhanced
kidney	bowman's capsule	Medium	Enhanced
kidney	collecting ducts	High	Enhanced
kidney	distal tubules	High	Enhanced
liver	cholangiocytes	Medium	Enhanced
liver	hepatocytes	Medium	Enhanced
lung	alveolar cells type II	Low	Enhanced
nasopharynx	basal cells	Medium	Enhanced
nasopharynx	ciliated cells (cell body)	High	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
pancreas	exocrine glandular cells	High	Enhanced
parathyroid gland	glandular cells	High	Enhanced
placenta	cytotrophoblasts	High	Enhanced
prostate	glandular cells	High	Enhanced
rectum	endocrine cells	High	Enhanced
rectum	enterocytes	High	Enhanced
rectum	enterocytes - Microvilli	High	Enhanced
rectum	goblet cells	High	Enhanced
salivary gland	glandular cells	High	Enhanced
seminal vesicle	glandular cells	High	Enhanced
skin 1	cells in basal layer	High	Enhanced
skin 1	cells in granular layer	Low	Enhanced
skin 1	cells in spinous layer	High	Enhanced
skin 1	eccrine glands	High	Enhanced
skin 1	langerhans cells	High	Enhanced
skin 1	melanocytes	High	Enhanced
skin 2	cells in basal layer	High	Enhanced
skin 2	cells in granular layer	Medium	Enhanced
skin 2	cells in spinous layer	High	Enhanced
skin 2	eccrine glands	High	Enhanced
skin 2	hair follicles	Medium	Enhanced
skin 2	langerhans cells	High	Enhanced
skin 2	melanocytes	High	Enhanced
small intestine	endocrine cells	Medium	Enhanced
small intestine	enterocytes	Medium	Enhanced
small intestine	enterocytes - Microvilli	Low	Enhanced
small intestine	goblet cells	Medium	Enhanced
small intestine	paneth cells	Medium	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced
thyroid gland	glandular cells	High	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
urinary bladder	urothelial cells	High	Enhanced
vagina	squamous epithelial cells	High	Enhanced

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
hereditary diffuse gastric adenocarcinoma	MONDO:0007648	C16	chapter2, Neoplasms		Orphanet:26106
ovarian cancer	MONDO:0008170	C56	chapter2, Neoplasms	OMIM:167000	Orphanet:213500
endometrial cancer	MONDO:0011962	C54	chapter2, Neoplasms	OMIM:608089
hereditary neoplastic syndrome	MONDO:0015356	-	-		Orphanet:140162
cleft lip with or without cleft palate	MONDO:0016034	Q36	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:1991
cleft lip with or without cleft palate	MONDO:0016034	Q37	chapter17, Congenital malformations, deformations and chromosomal abnormalities		Orphanet:1991
hereditary breast carcinoma	MONDO:0016419	C50	chapter2, Neoplasms	OMIM:114480	Orphanet:227535
blepharocheilodontic syndrome 1	MONDO:0054740	Q87	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:119580

Summary of P12830

Gene: CDH1, CDHE, UVO
Protein: Cadherin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P12830

Gene: CDH1, CDHE, UVO Protein: Cadherin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CDH1, CDHE, UVO
Protein: Cadherin-1