Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.6.4.-
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
4.2.99.-
Lyases;
Carbon-oxygen lyases;
Other carbon-oxygen lyases;
PDB | Resolution (Å) | PDB name |
---|---|---|
1JEQ | 2.7 | Crystal Structure of the Ku Heterodimer |
1JEY | 2.5 | Crystal Structure of the Ku heterodimer bound to DNA |
1JJR | The Three-Dimensional Structure of the C-terminal DNA Binding Domain of Human Ku70 | |
3RZX | 2.61 | Mouse importin alpha-Ku70 NLS peptide complex |
5Y3R | 6.6 | Cryo-EM structure of Human DNA-PK Holoenzyme |
6ERF | 3.01 | Complex of APLF factor and Ku heterodimer bound to DNA |
6ERG | 2.9 | Complex of XLF and heterodimer Ku bound to DNA |
6ERH | 2.8 | Complex of XLF and heterodimer Ku bound to DNA |
6ZHA | 3.91 | Cryo-EM structure of DNA-PK monomer |
6ZHE | 7.24 | Cryo-EM structure of DNA-PK dimer |
7AXZ | 3.2 | Ku70/80 complex apo form |
7K0Y | 3.7 | Cryo-EM structure of activated-form DNA-PK (complex VI) |
7K1J | 3.9 | CryoEM structure of inactivated-form DNA-PK (Complex III) |
7K1K | 4.1 | CryoEM structure of inactivated-form DNA-PK (Complex IV) |
7K1N | 3.9 | CryoEM structure of inactivated-form DNA-PK (Complex V) |
7LSY | 8.4 | NHEJ Short-range synaptic complex |
7LT3 | 4.6 | NHEJ Long-range synaptic complex |
7NFC | 4.14 | Cryo-EM structure of NHEJ super-complex (dimer) |
7NFE | 4.29 | Cryo-EM structure of NHEJ super-complex (monomer) |
7SGL | 3.0 | DNA-PK complex of DNA end processing |
7SU3 | 3.3 | CryoEM structure of DNA-PK complex VII |
7Z87 | 2.91 | DNA-PK in the active state |
7Z88 | 3.33 | DNA-PK in the intermediate state |
8AG4 | 2.46 | Vaccinia C16 protein bound to Ku70/Ku80 |
8AG5 | 3.47 | Vaccinia C16 protein bound to Ku70/Ku80 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006266 | DNA ligation |
Biological Process | GO:0002218 | activation of innate immune response |
Biological Process | GO:0071480 | cellular response to gamma radiation |
Biological Process | GO:0097680 | double-strand break repair via classical nonhomologous end joining |
Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
Biological Process | GO:0045087 | innate immune response |
Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
Biological Process | GO:0045621 | positive regulation of lymphocyte differentiation |
Biological Process | GO:0045860 | positive regulation of protein kinase activity |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Biological Process | GO:0000725 | recombinational repair |
Biological Process | GO:0048660 | regulation of smooth muscle cell proliferation |
Biological Process | GO:0000723 | telomere maintenance |
Molecular Function | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0016887 | ATP hydrolysis activity |
Molecular Function | GO:0008094 | ATP-dependent activity, acting on DNA |
Molecular Function | GO:0003677 | DNA binding |
Molecular Function | GO:0003678 | DNA helicase activity |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0030332 | cyclin binding |
Molecular Function | GO:0003684 | damaged DNA binding |
Molecular Function | GO:0003690 | double-stranded DNA binding |
Molecular Function | GO:0044877 | protein-containing complex binding |
Molecular Function | GO:0097110 | scaffold protein binding |
Molecular Function | GO:0042162 | telomeric DNA binding |
Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
Cellular Component | GO:0070418 | DNA-dependent protein kinase complex |
Cellular Component | GO:0043564 | Ku70:Ku80 complex |
Cellular Component | GO:0000781 | chromosome, telomeric region |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005576 | extracellular region |
Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0070419 | nonhomologous end joining complex |
Cellular Component | GO:0000783 | nuclear telomere cap complex |
Cellular Component | GO:0005730 | nucleolus |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0032993 | protein-DNA complex |
Cellular Component | GO:0032991 | protein-containing complex |
Cellular Component | GO:0034774 | secretory granule lumen |
Cellular Component | GO:0005667 | transcription regulator complex |
InterPro | InterPro name |
---|---|
IPR003034 | SAP domain |
IPR005160 | Ku70/Ku80 C-terminal arm |
IPR005161 | Ku70/Ku80, N-terminal alpha/beta |
IPR006164 | Ku70/Ku80 beta-barrel domain |
IPR006165 | Ku70 |
IPR016194 | SPOC-like, C-terminal domain superfamily |
IPR027388 | Ku70, bridge and pillars domain superfamily |
IPR036361 | SAP domain superfamily |
IPR036465 | von Willebrand factor A-like domain superfamily |
IPR047087 | Ku70, core domain |
Pfam | Pfam name |
---|---|
PF02037 | SAP domain |
PF02735 | Ku70/Ku80 beta-barrel domain |
PF03730 | Ku70/Ku80 C-terminal arm |
PF03731 | Ku70/Ku80 N-terminal alpha/beta domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-164843 | 2-LTR circle formation | Leaf | R-HSA-1643685 | Disease |
R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA | Internal node | R-HSA-168256 | Immune System |
R-HSA-3270619 | IRF3-mediated induction of type I IFN | Leaf | R-HSA-168256 | Immune System |
R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
Location | ECO term | Pubmed |
---|---|---|
Chromosome | ECO:0000269 | PubMed:22442688 |
Nucleus | ECO:0000269 | PubMed:22442688 |