MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.6.4.-	Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement;

Structure

PDB	Resolution (Å)	PDB name
1JEQ	2.7	Crystal Structure of the Ku Heterodimer
1JEY	2.5	Crystal Structure of the Ku heterodimer bound to DNA
1Q2Z		The 3D solution structure of the C-terminal region of Ku86
1RW2		Three-dimensional structure of Ku80 CTD
3RZ9	2.29	Mouse importin alpha-Ku80 NLS peptide complex
5Y3R	6.6	Cryo-EM structure of Human DNA-PK Holoenzyme
6ERF	3.01	Complex of APLF factor and Ku heterodimer bound to DNA
6ERG	2.9	Complex of XLF and heterodimer Ku bound to DNA
6ERH	2.8	Complex of XLF and heterodimer Ku bound to DNA
6ZH6	3.93	Cryo-EM structure of DNA-PKcs:Ku80ct194
6ZHA	3.91	Cryo-EM structure of DNA-PK monomer
6ZHE	7.24	Cryo-EM structure of DNA-PK dimer
7AXZ	3.2	Ku70/80 complex apo form
7K0Y	3.7	Cryo-EM structure of activated-form DNA-PK (complex VI)
7K17	4.3	Re-refined crystal structure of DNA-dependent protein kinase catalytic subunit complexed with Ku80 C-terminal helix
7K1J	3.9	CryoEM structure of inactivated-form DNA-PK (Complex III)
7K1K	4.1	CryoEM structure of inactivated-form DNA-PK (Complex IV)
7K1N	3.9	CryoEM structure of inactivated-form DNA-PK (Complex V)
7LSY	8.4	NHEJ Short-range synaptic complex
7LT3	4.6	NHEJ Long-range synaptic complex
7NFC	4.14	Cryo-EM structure of NHEJ super-complex (dimer)
7NFE	4.29	Cryo-EM structure of NHEJ super-complex (monomer)
7SGL	3.0	DNA-PK complex of DNA end processing
7SU3	3.3	CryoEM structure of DNA-PK complex VII
7SUD	3.6	CryoEM structure of DNA-PK complex VIII
7Z87	2.91	DNA-PK in the active state
7Z88	3.33	DNA-PK in the intermediate state
8AG4	2.46	Vaccinia C16 protein bound to Ku70/Ku80
8AG5	3.47	Vaccinia C16 protein bound to Ku70/Ku80

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006310	DNA recombination
Biological Process	GO:0002218	activation of innate immune response
Biological Process	GO:0007420	brain development
Biological Process	GO:0071475	cellular hyperosmotic salinity response
Biological Process	GO:0071481	cellular response to X-ray
Biological Process	GO:0071398	cellular response to fatty acid
Biological Process	GO:0071480	cellular response to gamma radiation
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor
Biological Process	GO:0006302	double-strand break repair
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining
Biological Process	GO:0060218	hematopoietic stem cell differentiation
Biological Process	GO:0071425	hematopoietic stem cell proliferation
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:1904430	negative regulation of t-circle formation
Biological Process	GO:0022008	neurogenesis
Biological Process	GO:0043085	positive regulation of catalytic activity
Biological Process	GO:0050769	positive regulation of neurogenesis
Biological Process	GO:0045860	positive regulation of protein kinase activity
Biological Process	GO:0051973	positive regulation of telomerase activity
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase
Biological Process	GO:0070198	protein localization to chromosome, telomeric region
Biological Process	GO:0000725	recombinational repair
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation
Biological Process	GO:0032204	regulation of telomere maintenance
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0034462	small-subunit processome assembly
Biological Process	GO:0000723	telomere maintenance
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0045027	DNA end binding
Molecular Function	GO:0003678	DNA helicase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0034511	U3 snoRNA binding
Molecular Function	GO:0003684	damaged DNA binding
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0008047	enzyme activator activity
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0042162	telomeric DNA binding
Molecular Function	GO:0000976	transcription cis-regulatory region binding
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Cellular Component	GO:0070418	DNA-dependent protein kinase complex
Cellular Component	GO:0043564	Ku70:Ku80 complex
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0070419	nonhomologous end joining complex
Cellular Component	GO:0000783	nuclear telomere cap complex
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032993	protein-DNA complex
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:1990904	ribonucleoprotein complex
Cellular Component	GO:0034774	secretory granule lumen
Cellular Component	GO:0090734	site of DNA damage
Cellular Component	GO:0032040	small-subunit processome

InterPro / Pfam

InterPro	InterPro name
IPR002035	von Willebrand factor, type A
IPR005160	Ku70/Ku80 C-terminal arm
IPR005161	Ku70/Ku80, N-terminal alpha/beta
IPR006164	Ku70/Ku80 beta-barrel domain
IPR014893	Ku, C-terminal
IPR016194	SPOC-like, C-terminal domain superfamily
IPR024193	Ku80
IPR036465	von Willebrand factor A-like domain superfamily
IPR036494	Ku, C-terminal domain superfamily

Pfam	Pfam name
PF02735	Ku70/Ku80 beta-barrel domain
PF03730	Ku70/Ku80 C-terminal arm
PF03731	Ku70/Ku80 N-terminal alpha/beta domain
PF08785	Ku C terminal domain like

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-164843	2-LTR circle formation	Leaf	R-HSA-1643685	Disease
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	Internal node	R-HSA-168256	Immune System
R-HSA-3270619	IRF3-mediated induction of type I IFN	Leaf	R-HSA-168256	Immune System
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	Leaf	R-HSA-73894	DNA Repair
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Chromosome	ECO:0000269	PubMed:22442688
Nucleus	ECO:0000269	PubMed:22442688
Nucleus	ECO:0000269	PubMed:32103174
Nucleus, nucleolus	ECO:0000269	PubMed:22002106
Nucleus, nucleolus	ECO:0000269	PubMed:32103174

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Supported
adrenal gland	glandular cells	Medium	Supported
appendix	endocrine cells	High	Supported
appendix	enterocytes	High	Supported
appendix	goblet cells	High	Supported
appendix	non-germinal center cells	High	Supported
bone marrow	hematopoietic cells	High	Supported
breast	glandular cells	High	Supported
breast	myoepithelial cells	High	Supported
bronchus	respiratory epithelial cells	Medium	Supported
caudate	glial cells	High	Supported
caudate	neuronal cells	Medium	Supported
cerebellum	Purkinje cells	High	Supported
cerebellum	cells in granular layer	High	Supported
cerebellum	cells in molecular layer	High	Supported
cerebral cortex	endothelial cells	High	Supported
cerebral cortex	glial cells	High	Supported
cerebral cortex	neuronal cells	High	Supported
cervix	squamous epithelial cells	High	Supported
colon	endocrine cells	High	Supported
colon	endothelial cells	High	Supported
colon	enterocytes	High	Supported
colon	fibroblasts	Medium	Supported
colon	goblet cells	High	Supported
colon	mucosal lymphoid cells	High	Supported
duodenum	endocrine cells	High	Supported
duodenum	enterocytes	High	Supported
duodenum	glands of Brunner	High	Supported
duodenum	goblet cells	High	Supported
duodenum	paneth cells	High	Supported
endometrium 1	cells in endometrial stroma	High	Supported
endometrium 1	glandular cells	High	Supported
endometrium 2	cells in endometrial stroma	High	Supported
endometrium 2	glandular cells	High	Supported
epididymis	glandular cells	High	Supported
esophagus	squamous epithelial cells	High	Supported
fallopian tube	glandular cells	High	Supported
gallbladder	glandular cells	High	Supported
heart muscle	cardiomyocytes	Medium	Supported
hippocampus	glial cells	High	Supported
hippocampus	neuronal cells	Medium	Supported
kidney	cells in glomeruli	High	Supported
kidney	cells in tubules	High	Supported
lung	alveolar cells type I	High	Supported
lung	alveolar cells type II	High	Supported
lung	endothelial cells	High	Supported
lung	macrophages	High	Supported
lymph node	germinal center cells	High	Supported
lymph node	non-germinal center cells	High	Supported
nasopharynx	respiratory epithelial cells	Medium	Supported
oral mucosa	squamous epithelial cells	Medium	Supported
ovary	ovarian stroma cells	High	Supported
pancreas	exocrine glandular cells	Medium	Supported
parathyroid gland	glandular cells	High	Supported
placenta	decidual cells	High	Supported
placenta	trophoblastic cells	High	Supported
prostate	glandular cells	High	Supported
rectum	endocrine cells	High	Supported
rectum	enterocytes	High	Supported
rectum	fibroblasts	Medium	Supported
rectum	goblet cells	High	Supported
rectum	mucosal lymphoid cells	High	Supported
salivary gland	glandular cells	High	Supported
seminal vesicle	glandular cells	High	Supported
skeletal muscle	myocytes	Medium	Supported
skin 1	cells in basal layer	High	Supported
skin 1	cells in granular layer	High	Supported
skin 1	cells in spinous layer	High	Supported
skin 1	endothelial cells	High	Supported
skin 1	fibrohistiocytic cells	High	Supported
skin 1	hair follicles	High	Supported
skin 1	langerhans cells	High	Supported
skin 1	lymphocytes	High	Supported
skin 1	melanocytes	High	Supported
skin 1	vascular mural cells	High	Supported
skin 2	cells in basal layer	High	Supported
skin 2	cells in corneal layer	High	Supported
skin 2	cells in granular layer	High	Supported
skin 2	cells in spinous layer	High	Supported
skin 2	endothelial cells	High	Supported
skin 2	fibrohistiocytic cells	High	Supported
skin 2	langerhans cells	High	Supported
skin 2	lymphocytes	High	Supported
skin 2	melanocytes	High	Supported
skin 2	vascular mural cells	High	Supported
small intestine	endocrine cells	High	Supported
small intestine	enterocytes	High	Supported
small intestine	goblet cells	High	Supported
small intestine	paneth cells	High	Supported
smooth muscle	smooth muscle cells	High	Supported
soft tissue 1	chondrocytes	Low	Supported
soft tissue 1	fibroblasts	Medium	Supported
soft tissue 1	peripheral nerve	Medium	Supported
soft tissue 2	fibroblasts	Medium	Supported
soft tissue 2	peripheral nerve	Medium	Supported
spleen	cells in red pulp	High	Supported
spleen	cells in white pulp	High	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	High	Supported
testis	Leydig cells	Medium	Supported
testis	pachytene spermatocytes	High	Supported
testis	peritubular cells	Medium	Supported
testis	preleptotene spermatocytes	Medium	Supported
testis	round or early spermatids	High	Supported
testis	sertoli cells	Medium	Supported
testis	spermatogonia cells	High	Supported
thyroid gland	glandular cells	High	Supported
tonsil	germinal center cells	High	Supported
tonsil	non-germinal center cells	High	Supported
tonsil	squamous epithelial cells	High	Supported
urinary bladder	urothelial cells	High	Supported
vagina	squamous epithelial cells	Medium	Supported

Summary of P13010

Gene: XRCC5, G22P2
Protein: X-ray repair cross-complementing protein 5

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P13010

Gene: XRCC5, G22P2 Protein: X-ray repair cross-complementing protein 5

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: XRCC5, G22P2
Protein: X-ray repair cross-complementing protein 5