MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1B3A	1.6	TOTAL CHEMICAL SYNTHESIS AND HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE POTENT ANTI-HIV PROTEIN AOP-RANTES
1EQT	1.6	MET-RANTES
1HRJ		HUMAN RANTES, NMR, 13 STRUCTURES
1RTN		PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE
1RTO		PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE
1U4L	2.0	human RANTES complexed to heparin-derived disaccharide I-S
1U4M	2.0	human RANTES complexed to heparin-derived disaccharide III-S
1U4P	1.7	Crystal Structure of human RANTES mutant K45E
1U4R	2.2	Crystal Structure of human RANTES mutant 44-AANA-47
2L9H		Oligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS Data
2VXW	1.7	Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-RANTES
5CMD	3.086	Oligomer crystal structure of CC chemokine 5 (CCL5)
5COY	1.443	Crystal structure of CC chemokine 5 (CCL5)
5DNF	2.549	Crystal structure of CC chemokine 5 (CCL5) oligomer in complex with heparin
5L2U	2.28	Oligomer crystal structure of CC chemokine 5 (CCL5)
5UIW	2.204	Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5
6AEZ	1.63	Crystal structure of human CCL5 trimer
6C6D	5.5	20mer crystal structure of CC chemokine 5 (CCL5)
6FGP		NMR solution structure of monomeric CCL5 in complex with a doubly-sulfated N-terminal segment of CCR5
6LOG	2.55	Crystal structure of human CCL5-12AAA14 mutant
6STK	1.52	Crystal structure of the CC-chemokine 5 (CCL5) E66S mutation
7F1R	3.0	Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi
7O7F	3.15	Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

GO term

GO ontology	GO term	GO description
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0031584	activation of phospholipase D activity
Biological Process	GO:0006816	calcium ion transport
Biological Process	GO:0007267	cell-cell signaling
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus
Biological Process	GO:0071347	cellular response to interleukin-1
Biological Process	GO:0071407	cellular response to organic cyclic compound
Biological Process	GO:0071356	cellular response to tumor necrosis factor
Biological Process	GO:0071346	cellular response to type II interferon
Biological Process	GO:0098586	cellular response to virus
Biological Process	GO:0070098	chemokine-mediated signaling pathway
Biological Process	GO:0006935	chemotaxis
Biological Process	GO:0002407	dendritic cell chemotaxis
Biological Process	GO:0048245	eosinophil chemotaxis
Biological Process	GO:0006887	exocytosis
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0006874	intracellular calcium ion homeostasis
Biological Process	GO:0007159	leukocyte cell-cell adhesion
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway
Biological Process	GO:0048247	lymphocyte chemotaxis
Biological Process	GO:0048246	macrophage chemotaxis
Biological Process	GO:0002548	monocyte chemotaxis
Biological Process	GO:0043922	negative regulation by host of viral transcription
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway
Biological Process	GO:0070233	negative regulation of T cell apoptotic process
Biological Process	GO:0045071	negative regulation of viral genome replication
Biological Process	GO:0042119	neutrophil activation
Biological Process	GO:0030593	neutrophil chemotaxis
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0043547	positive regulation of GTPase activity
Biological Process	GO:0070234	positive regulation of T cell apoptotic process
Biological Process	GO:0010820	positive regulation of T cell chemotaxis
Biological Process	GO:2000406	positive regulation of T cell migration
Biological Process	GO:0042102	positive regulation of T cell proliferation
Biological Process	GO:0010536	positive regulation of activation of Janus kinase activity
Biological Process	GO:0051928	positive regulation of calcium ion transport
Biological Process	GO:0045785	positive regulation of cell adhesion
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin
Biological Process	GO:0031328	positive regulation of cellular biosynthetic process
Biological Process	GO:0034112	positive regulation of homotypic cell-cell adhesion
Biological Process	GO:0045089	positive regulation of innate immune response
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis
Biological Process	GO:2000503	positive regulation of natural killer cell chemotaxis
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process	GO:0042327	positive regulation of phosphorylation
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation
Biological Process	GO:0045948	positive regulation of translational initiation
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
Biological Process	GO:0045070	positive regulation of viral genome replication
Biological Process	GO:0043491	protein kinase B signaling
Biological Process	GO:0050863	regulation of T cell activation
Biological Process	GO:0002676	regulation of chronic inflammatory response
Biological Process	GO:0050796	regulation of insulin secretion
Biological Process	GO:0009636	response to toxic substance
Biological Process	GO:0009615	response to virus
Molecular Function	GO:0048020	CCR chemokine receptor binding
Molecular Function	GO:0031726	CCR1 chemokine receptor binding
Molecular Function	GO:0031729	CCR4 chemokine receptor binding
Molecular Function	GO:0031730	CCR5 chemokine receptor binding
Molecular Function	GO:0042056	chemoattractant activity
Molecular Function	GO:0008009	chemokine activity
Molecular Function	GO:0046817	chemokine receptor antagonist activity
Molecular Function	GO:0042379	chemokine receptor binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity
Molecular Function	GO:0016004	phospholipase activator activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0004672	protein kinase activity
Molecular Function	GO:0043621	protein self-association
Molecular Function	GO:0030298	receptor signaling protein tyrosine kinase activator activity
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space

InterPro	InterPro name
IPR000827	CC chemokine, conserved site
IPR001811	Chemokine interleukin-8-like domain
IPR036048	Chemokine interleukin-8-like superfamily
IPR039809	Chemokine beta/gamma/delta

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-380108	Chemokine receptors bind chemokines	Leaf	R-HSA-162582	Signal Transduction
R-HSA-418594	G alpha (i) signalling events	Internal node	R-HSA-162582	Signal Transduction
R-HSA-6783783	Interleukin-10 signaling	Leaf	R-HSA-168256	Immune System

Tissue	Cell type	Expression level	Reliability
appendix	non-germinal center cells	Medium	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
colon	mucosal lymphoid cells	Medium	Enhanced
endometrium	ciliated epithelial cells	Low	Enhanced
endometrium	lymphocytes	Medium	Enhanced
endometrium	nonciliated glandular epithelial cells	Low	Enhanced
endometrium	nonciliated luminal epithelial cells	Low	Enhanced
placenta	trophoblastic cells	Low	Enhanced
rectum	mucosal lymphoid cells	Medium	Enhanced
spleen	cells in red pulp	High	Enhanced

Summary of P13501

Gene: CCL5, D17S136E, SCYA5
Protein: C-C motif chemokine 5

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P13501

Gene: CCL5, D17S136E, SCYA5 Protein: C-C motif chemokine 5

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: CCL5, D17S136E, SCYA5
Protein: C-C motif chemokine 5