MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
3V4P	3.15	crystal structure of a4b7 headpiece complexed with Fab ACT-1
3V4V	3.1	crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376
4HKC	2.2	14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
5C7Z	2.77	AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide
5FPI	2.77	Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE

GO term

GO ontology	GO term	GO description
Biological Process	GO:0030183	B cell differentiation
Biological Process	GO:0060385	axonogenesis involved in innervation
Biological Process	GO:0033627	cell adhesion mediated by integrin
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0140039	cell-cell adhesion in response to extracellular stimulus
Biological Process	GO:0033631	cell-cell adhesion mediated by integrin
Biological Process	GO:0007160	cell-matrix adhesion
Biological Process	GO:0003366	cell-matrix adhesion involved in ameboidal cell migration
Biological Process	GO:1904646	cellular response to amyloid-beta
Biological Process	GO:0071345	cellular response to cytokine stimulus
Biological Process	GO:1990771	clathrin-dependent extracellular exosome endocytosis
Biological Process	GO:0050904	diapedesis
Biological Process	GO:0035987	endodermal cell differentiation
Biological Process	GO:0034113	heterotypic cell-cell adhesion
Biological Process	GO:0098657	import into cell
Biological Process	GO:0007229	integrin-mediated signaling pathway
Biological Process	GO:0007159	leukocyte cell-cell adhesion
Biological Process	GO:0050901	leukocyte tethering or rolling
Biological Process	GO:0090074	negative regulation of protein homodimerization activity
Biological Process	GO:1990138	neuron projection extension
Biological Process	GO:2000406	positive regulation of T cell migration
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process
Biological Process	GO:1903238	positive regulation of leukocyte tethering or rolling
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation
Biological Process	GO:0043113	receptor clustering
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading
Molecular Function	GO:0050839	cell adhesion molecule binding
Molecular Function	GO:0015026	coreceptor activity
Molecular Function	GO:0001968	fibronectin binding
Molecular Function	GO:0005178	integrin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:1990405	protein antigen binding
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0009897	external side of plasma membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0034668	integrin alpha4-beta1 complex
Cellular Component	GO:0034669	integrin alpha4-beta7 complex
Cellular Component	GO:0008305	integrin complex
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR000413	Integrin alpha chain
IPR013517	FG-GAP repeat
IPR013519	Integrin alpha beta-propellor
IPR013649	Integrin alpha-2
IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
IPR028994	Integrin alpha, N-terminal
IPR032695	Integrin domain superfamily

Pfam	Pfam name
PF01839	FG-GAP repeat
PF08441	Integrin alpha

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Leaf	R-HSA-168256	Immune System
R-HSA-202733	Cell surface interactions at the vascular wall	Internal node	R-HSA-109582	Hemostasis
R-HSA-216083	Integrin cell surface interactions	Leaf	R-HSA-1474244	Extracellular matrix organization
R-HSA-8949275	RUNX3 Regulates Immune Response and Cell Migration	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9679191	Potential therapeutics for SARS	Leaf	R-HSA-1643685	Disease

Summary of P13612

Gene: ITGA4, CD49D
Protein: Integrin alpha-4

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P13612

Gene: ITGA4, CD49D Protein: Integrin alpha-4

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ITGA4, CD49D
Protein: Integrin alpha-4