Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.1.40
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor;
pyruvate kinase
2.7.10.2
Transferases;
Transferring phosphorus-containing groups;
Protein-tyrosine kinases;
non-specific protein-tyrosine kinase
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1T5A | 2.8 | Human Pyruvate Kinase M2 |
| 1ZJH | 2.2 | Structure of human muscle pyruvate kinase (PKM2) |
| 3BJF | 2.03 | Pyruvate kinase M2 is a phosphotyrosine binding protein |
| 3BJT | 2.5 | Pyruvate kinase M2 is a phosphotyrosine binding protein |
| 3G2G | 2.0 | S437Y Mutant of human muscle pyruvate kinase, isoform M2 |
| 3GQY | 1.85 | Activator-Bound Structure of Human Pyruvate Kinase M2 |
| 3GR4 | 1.6 | Activator-Bound Structure of Human Pyruvate Kinase M2 |
| 3H6O | 2.0 | Activator-Bound Structure of Human Pyruvate Kinase M2 |
| 3ME3 | 1.95 | Activator-Bound Structure of Human Pyruvate Kinase M2 |
| 3SRD | 2.902 | Human M2 pyruvate kinase in complex with fructose 1-6 bisphosphate and Oxalate. |
| 3SRF | 2.845 | Human M1 pyruvate kinase |
| 3SRH | 2.6 | Human M2 pyruvate kinase |
| 3U2Z | 2.1 | Activator-Bound Structure of Human Pyruvate Kinase M2 |
| 4B2D | 2.3 | human PKM2 with L-serine and FBP bound. |
| 4FXF | 2.55 | Structure of M2 pyruvate kinase in complex with phenylalanine |
| 4FXJ | 2.9 | Structure of M2 pyruvate kinase in complex with phenylalanine |
| 4G1N | 2.3 | PKM2 in complex with an activator |
| 4JPG | 2.33 | 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators |
| 4QG6 | 3.207 | crystal structure of PKM2-Y105E mutant |
| 4QG8 | 2.3 | crystal structure of PKM2-K305Q mutant |
| 4QG9 | 2.381 | crystal structure of PKM2-R399E mutant |
| 4QGC | 2.296 | crystal structure of PKM2-K422R mutant |
| 4RPP | 2.585 | crystal structure of PKM2-K422R mutant bound with FBP |
| 4WJ8 | 2.87 | Human Pyruvate Kinase M2 Mutant C424A |
| 4YJ5 | 2.41 | Crystal structure of PKM2 mutant |
| 5X0I | 2.64 | Crystal structure of PKM2 R399E mutant complexed with FBP and serine |
| 5X1V | 2.1 | PKM2 in complex with compound 2 |
| 5X1W | 3.0 | PKM2 in complex with compound 5 |
| 6B6U | 1.35 | Pyruvate Kinase M2 mutant - S437Y |
| 6GG3 | 3.72 | Crystal structure of M2 PYK in complex with Alanine. |
| 6GG4 | 2.46 | Crystal structure of M2 PYK in complex with Phenyalanine. |
| 6GG5 | 3.2 | Crystal structure of M2 PYK in complex with Tryptophan. |
| 6GG6 | 2.96 | Crystal structure of M2 PYK in complex with Serine. |
| 6JFB | 2.12 | Crystal structure of human pyruvate kinase M2 isoform |
| 6NU1 | 2.25 | Crystal Structure of Human PKM2 in Complex with L-cysteine |
| 6NU5 | 1.6 | Pyruvate Kinase M2 Mutant - S437Y in Complex with L-cysteine |
| 6NUB | 1.7 | Pyruvate Kinase M2 Mutant - S437Y in Complex with L-serine |
| 6TTF | 3.2 | PKM2 in complex with Compound 5 |
| 6TTH | 2.6 | PKM2 in complex with L-threonine |
| 6TTI | 2.5 | PKM2 in complex with Compound 6 |
| 6TTQ | 2.7 | PKM2 in complex with Compound 10 |
| 6V74 | 2.32 | Crystal Structure of Human PKM2 in Complex with L-asparagine |
| 6V75 | 2.85 | Crystal Structure of Human PKM2 in Complex with L-aspartate |
| 6V76 | 2.75 | Crystal Structure of Human PKM2 in Complex with L-valine |
| 6WP3 | 1.84 | Pyruvate Kinase M2 Mutant-K433Q |
| 6WP4 | 1.9 | Pyruvate Kinase M2 mutant-S37E |
| 6WP5 | 2.17 | Pyruvate Kinase M2 mutant-S37D |
| 6WP6 | 2.45 | Pyruvate Kinase M2 mutant-S37E K433E |
| 7L21 | 2.29 | Pyruvate Kinase M2 mutant-N70D |
| 8HMQ | 2.5 | Crystal Structure of PKM2 mutant P403A |
| 8HMR | 2.6 | Crystal Structure of PKM2 mutant L144P |
| 8HMS | 2.1 | Crystal Structure of PKM2 mutant C474S |
| 8HMU | 2.5 | Crystal Structure of PKM2 mutant R516C |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0016310 | phosphorylation |
| Biological Process | GO:2000767 | positive regulation of cytoplasmic translation |
| Biological Process | GO:1903672 | positive regulation of sprouting angiogenesis |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0012501 | programmed cell death |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0023026 | MHC class II protein complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0035402 | histone H3T11 kinase activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030955 | potassium ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004713 | protein tyrosine kinase activity |
| Molecular Function | GO:0004743 | pyruvate kinase activity |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0062023 | collagen-containing extracellular matrix |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1903561 | extracellular vesicle |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005791 | rough endoplasmic reticulum |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Cellular Component | GO:0031982 | vesicle |
| InterPro
|
InterPro name |
|---|---|
| IPR001697 | Pyruvate kinase |
| IPR011037 | Pyruvate kinase-like, insert domain superfamily |
| IPR015793 | Pyruvate kinase, barrel |
| IPR015795 | Pyruvate kinase, C-terminal |
| IPR015806 | Pyruvate kinase, insert domain superfamily |
| IPR015813 | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily |
| IPR018209 | Pyruvate kinase, active site |
| IPR036918 | Pyruvate kinase, C-terminal domain superfamily |
| IPR040442 | Pyruvate kinase-like domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00224 | Pyruvate kinase, barrel domain |
| PF02887 | Pyruvate kinase, alpha/beta domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-70171 | Glycolysis | Internal node | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:25263439 |
| Cytoplasm | ECO:0000269 | PubMed:26787900 |
| Cytoplasm | ECO:0000269 | PubMed:32268273 |
| Cytoplasm | ECO:0000305 | |
| Nucleus | ECO:0000269 | PubMed:17308100 |
| Nucleus | ECO:0000269 | PubMed:18191611 |
| Nucleus | ECO:0000269 | PubMed:22056988 |
| Nucleus | ECO:0000269 | PubMed:22901803 |
| Nucleus | ECO:0000269 | PubMed:24120661 |
| Nucleus | ECO:0000269 | PubMed:26787900 |
| Nucleus | ECO:0000269 | PubMed:32268273 |