Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1CQT | 3.2 | CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT |
| 1E3O | 1.9 | Crystal structure of Oct-1 POU dimer bound to MORE |
| 1GT0 | 2.6 | Crystal structure of a POU/HMG/DNA ternary complex |
| 1HF0 | 2.7 | Crystal structure of the DNA-binding domain of Oct-1 bound to DNA as a dimer |
| 1O4X | TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT | |
| 1OCT | 3.0 | CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES |
| 1POG | SOLUTION STRUCTURE OF THE OCT-1 POU-HOMEO DOMAIN DETERMINED BY NMR AND RESTRAINED MOLECULAR DYNAMICS | |
| 1POU | THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:1902895 | positive regulation of miRNA transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000327 | POU-specific domain |
| IPR000972 | Octamer-binding transcription factor |
| IPR001356 | Homeobox domain |
| IPR009057 | Homeobox-like domain superfamily |
| IPR010982 | Lambda repressor-like, DNA-binding domain superfamily |
| IPR013847 | POU domain |
| IPR017970 | Homeobox, conserved site |
| IPR045703 | POU domain, class 2, transcription factor 1, C-terminal |
| Pfam
|
Pfam name |
|---|---|
| PF00046 | Homeodomain |
| PF00157 | Pou domain - N-terminal to homeobox domain |
| PF19536 | POU domain, class 2, transcription factor 1 C-terminal |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-749476 | RNA Polymerase III Abortive And Retractive Initiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-9018519 | Estrogen-dependent gene expression | Leaf | R-HSA-162582 | Signal Transduction |