MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.1.1.21	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; aldose reductase
1.1.1.300	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; NADP-retinol dehydrogenase
1.1.1.372	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; D/L-glyceraldehyde reductase
1.1.1.54	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; allyl-alcohol dehydrogenase

Structure

PDB	Resolution (Å)	PDB name
3S3G	1.8	Crystal Structure of Human Aldose Reductase Complexed with Tolmetin
3LZ3	1.03	Human aldose reductase mutant T113S complexed with IDD388
4LB4	0.8	Crystal structure of human AR complexed with NADP+ and {2-[(4-bromo-2,3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid
3T42	1.28	Human aldose reductase in complex with a nitrile-containing IDD inhibitor
6Y03	1.69	Structure of Human Aldose Reductase Mutant L300/301A with a Citrate Molecule Bound in the Anion Binding Pocket
2PDJ	1.57	Human aldose reductase mutant L300A complexed with IDD393.
3LQG	1.35	Human aldose reductase mutant T113A complexed with IDD388
4PRT	0.96	Human Aldose Reductase complexed with Schl12221 ({2-[5-(3-NITROPHENYL)FURAN-2-YL]PHENYL}ACETIC ACID) at 0.96 A
2PD9	1.55	Human aldose reductase mutant V47I complexed with fidarestat.
1EF3	2.8	FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE
6XUM	0.97	Human Aldose Reductase Mutant L300/301A in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid)
2PDC	1.65	Human aldose reductase mutant F121P complexed with IDD393.
1Z89	1.43	Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor
4JIR	2.0	Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat
2INZ	1.95	Crystal Structure of Aldose Reductase complexed with 2-Hydroxyphenylacetic Acid
2INE	1.9	Crystal Structure of Aldose Reductase complexed with Phenylacetic Acid
2IKH	1.55	Human aldose reductase complexed with nitrofuryl-oxadiazol inhibitor at 1.55 A
2ISF	2.0	Crystal Structure of C298A W219Y Aldose Reductase complexed with Phenylacetic Acid
2ACS	1.76	AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE
6TUF	1.15	Human Aldose Reductase in complex with ALR43
6TD8	0.97	Human Aldose Reductase Mutant L301A in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid)
2HVN	1.58	Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation after one day (1day_cocryst)
2PDU	1.55	Human aldose reductase mutant C303D complexed with IDD393.
2IPW	2.0	Crystal Structure of C298A W219Y Aldose Reductase complexed with Dichlorophenylacetic acid
4Q7B	1.19	Human Aldose Reductase complexed with a ligand with an IDD structure ([2-(benzylcarbamoyl)-5-fluorophenoxy]acetic acid) at 1.19 A
1AZ2	2.9	CITRATE BOUND, C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
4QX4	1.259	Human Aldose Reductase complexed with a ligand with a new scaffold at 1.26 A
1IEI	2.5	CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.
4PR4	1.06	Human Aldose Reductase complexed with Schl7802 at 1.06 A
4XZI	2.45	Crystal structure of human Aldose Reductase complexed with NADP+ and JF0049
4IGS	0.85	Crystal structure of human Aldose Reductase complexed with NADP+ and JF0064
6T7Q	1.01	Human Aldose Reductase Mutant L301A in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid)
2PFH	0.85	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594.
2PDN	1.7	Human aldose reductase mutant S302R complexed with uracil-type inhibitor.
2PDH	1.45	Human aldose reductase mutant L300P complexed with uracil-type inhibitor at 1.45 A.
2IKJ	1.55	Human aldose reductase complexed with nitro-substituted IDD-type inhibitor
4NKC	1.12	Human Aldose Reductase complexed with Schl7764 at 1.12 A
6F81	0.97	AKR1B1 at 0.75 MGy radiation dose.
4LAZ	0.85	Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(4-iodobenzyl)carbamoyl]phenoxy}acetic acid
4PRR	1.01	Human Aldose Reductase complexed with Schl7815 ((3-[3-(5-NITROFURAN-2-YL)PHENYL]PROPANOIC ACID)at 1.01 A
4GQ0	2.1	Crystal structure of AKR1B10 complexed with NADP+ and Caffeic acid phenethyl ester
6Y1P	0.94	Human Aldose Reductase Mutant L300/301A in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid)
4PUU	1.14	Human Aldose Reductase complexed with a ligand with an IDD structure (2-(2-carbamoyl-5-fluoro-phenoxy)acetic acid) at 1.14 A
1X97	1.4	Crystal structure of Aldose Reductase complexed with 2R4S (Stereoisomer of Fidarestat, 2S4S)
2PEV	0.9	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.
1T40	1.8	Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5
4QBX	0.98	Human Aldose Reductase complexed with a ligand with an IDD structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) at 0.98 A
3LD5	1.27	Human aldose reductase mutant T113S complexed with IDD594
4QR6	1.05	Human Aldose Reductase complexed with a ligand with an IDD structure (2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-5-fluoro-phenoxy]acetic acid) at 1.05 A
4LB3	0.8	Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid
3LEP	0.99	Human Aldose Reductase mutant T113C in complex with IDD388
2IQD	2.0	Crystal Structure of Aldose Reductase complexed with Lipoic Acid
2I16	0.81	Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 15K
4YS1	1.07	Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A.
2PDL	1.47	Human aldose reductase mutant L301M complexed with tolrestat.
2NVD	1.55	Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (2)
4LAU	0.843	Crystal structure of human AR complexed with NADP+ and {2-[(4-bromobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid
6F8O	1.17	AKR1B1 at 3.45 MGy radiation dose.
3GHT	1.1	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Third stage of radiation damage.
3P2V	1.69	Novel Benzothiazepine Inhibitor in Complex with human Aldose Reductase
3G5E	1.8	Human aldose reductase complexed with IDD 740 inhibitor
2FZ8	1.48	Human Aldose reductase complexed with inhibitor zopolrestat at 1.48 A(1 day soaking).
2QXW	0.8	Perdeuterated alr2 in complex with idd594
3LBO	1.1	Human aldose reductase mutant T113C complexed with IDD594
6F84	1.09	AKR1B1 at 2.55 MGy radiation dose.
3LQL	1.13	Human Aldose Reductase mutant T113A complexed with IDD 594
5OUJ	0.96	Crystal structure of human AKR1B1 complexed with NADP+ and compound 39
3ONC	1.06	Bond breakage and relocation of a covalently bound bromine of IDD594 in a complex with hAR T113A mutant after moderate radiation dose
2J8T	0.82	Human aldose reductase in complex with NADP and citrate at 0.82 angstrom
3U2C	1.0	Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution
2DUX	1.6	Crystal structure of human Aldose Reductase complexed with zopolrestat after 3 days soaking (3days_soaked_1)
6F7R	0.92	AKR1B1 at 0.03 MGy radiation dose.
2PZN	1.0	The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant
3M64	1.3	Human aldose reductase mutant T113V complexed with IDD393
5HA7	1.65	Human Aldose Reductase in Complex with NADP+ and WY14643 in Space Group P212121
3M4H	0.94	Human Aldose Reductase mutant T113V complexed with IDD388
6SYW	0.93	human Aldose Reductase in complex with SAR25
1XGD	2.1	Apo R268A human aldose reductase
3GHS	1.0	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Second stage of radiation damage.
3BCJ	0.78	Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S) at 0.78 A
2PDB	1.6	Human aldose reductase mutant F121P complexed with zopolrestat.
1PWL	1.1	Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat
3Q67	1.55	Human Aldose Reductase C298S mutant in Complex with NADP+ in Space Group P212121
2HV5	1.59	Human Aldose Reductase complexed with inhibitor zopolrestat after three days soaking (3days_soaked_3)
3RX3	1.9	Crystal Structure of Human Aldose Reductase Complexed with Sulindac
2DV0	1.62	Human Aldose Reductase complexed with zopolrestat after 6 days soaking(6days_soaked_2)
2ACU	1.76	TYROSINE-48 IS THE PROTON DONOR AND HISTIDINE-110 DIRECTS SUBSTRATE STEREOCHEMICAL SELECTIVITY IN THE REDUCTION REACTION OF HUMAN ALDOSE REDUCTASE: ENZYME KINETICS AND THE CRYSTAL STRUCTURE OF THE Y48H MUTANT ENZYME
2ACQ	1.76	AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE
5OUK	0.959	Crystal structure of human AKR1B1 complexed with NADP+ and compound 41
3ONB	1.45	Bond breakage and relocation of a covalently bound bromine of IDD594 in a complex with hAR T113A mutant after extensive radiation dose
4YU1	1.02	Human Aldose Reductase complexed with Schl12134 (3-[5-(3-nitrophenyl)-2-thienyl]propanoic acid) at 1.02 A
2IKI	1.47	Human aldose reductase complexed with halogenated IDD-type inhibitor
3LZ5	0.95	Human aldose reductase mutant T113V complexed with IDD594
3MC5	1.14	Human Aldose Reductase mutant T113V in complex with IDD393 crystallized in spacegroup P1
6TUC	1.06	Human Aldose Reductase in complex with ALR25
6T3P	0.97	Human Aldose Reductase Mutant L300A in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid)
4RPQ	1.2	Human Aldose Reductase complexed with a ligand with an IDD structure at 1.20 A (1)
6T5G	1.28	Structure of Human Aldose Reductase Mutant L300A with a Citrate Molecule Bound in the Anion Binding Pocket
6F82	1.03	AKR1B1 at 1.65 MGy radiation dose.
2PDG	1.42	Human aldose reductase with uracil-type inhibitor at 1.42A.
2I17	0.81	Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K
2FZB	1.5	Human Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution.
2HVO	1.65	Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation (10days_cocryst)
1X96	1.4	Crystal structure of Aldose Reductase with citrates bound in the active site
3GHR	1.0	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. First stage of radiation damage
2ACR	1.76	AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE
1US0	0.66	Human Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom
3Q65	2.09	Human Aldose Reductase in Complex with NADP+ in Space Group P212121
2PDX	1.65	Human aldose reductase double mutant S302R-C303D complexed with zopolrestat.
2FZ9	1.6	Human Aldose Reductase complexed with inhibitor zopolrestat after six days soaking.
2PDK	1.55	Human aldose reductase mutant L301M complexed with sorbinil.
1Z8A	0.95	Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor
3RX4	2.0	Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide
1MAR	1.8	REFINED 1.8 ANGSTROMS STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE POTENT INHIBITOR ZOPOLRESTAT
2F2K	1.94	Aldose reductase tertiary complex with NADPH and DEG
2IKG	1.43	Aldose reductase complexed with nitrophenyl-oxadiazol type inhibitor at 1.43 A
3GHU	1.2	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Forth stage of radiation damage.
2PDQ	1.73	Human aldose reductase mutant C303D complexed with uracil-type inhibitor.
4GCA	0.9	Complex of Aldose Reductase with inhibitor IDD 1219
3RX2	1.9	Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone
3V35	1.9	Aldose reductase complexed with a nitro compound
3DN5	1.45	Aldose Reductase in complex with novel biarylic inhibitor
2DUZ	1.6	Human Aldose Reductase complexed with inhibitor zopolrestat after 3 days soaking (3days_soaked_2)
4LBR	0.8	Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid
2PF8	0.85	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is equal to concentration of IDD594.
4QXI	0.867	Crystal structure of human AR complexed with NADP+ and AK198
2PDF	1.56	Human aldose reductase mutant L300P complexed with zopolrestat.
2IS7	1.7	Crystal Structure of Aldose Reductase complexed with Dichlorophenylacetic acid
2PDP	1.65	Human aldose reductase mutant S302R complexed with IDD 393.
2PDM	1.75	Human aldose reductase mutant S302R complexed with zopolrestat.
3M0I	1.07	Human Aldose Reductase mutant T113V in complex with Zopolrestat
1X98	1.3	Crystal structure of Aldose Reductase complexed with 2S4R (Stereoisomer of Fidarestat, 2S4S)
1EL3	1.7	HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
2PDW	1.55	Human aldose reductase mutant C303D complexed with fidarestat.
6TXP	0.95	Human Aldose Reductase Mutant L300A in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid)
4LBS	0.76	Crystal structure of human AR complexed with NADP+ and {2-[(4-bromo-2,6-difluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid
2PDI	1.55	Human aldose reductase mutant L300A complexed with zopolrestat at 1.55 A.
5OU0	0.94	Crystal structure of human AKR1B1 complexed with NADP+ and compound 37
4PUW	1.12	Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A
2PD5	1.6	Human aldose reductase mutant V47I complexed with zopolrestat
2NVC	1.65	Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)
1AZ1	1.8	ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
2R24	1.752	Human Aldose Reductase structure
3MB9	1.65	Human Aldose Reductase mutant T113A complexed with Zopolrestat
2AGT	1.0	Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat
4XZH	1.0	Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048
1PWM	0.92	Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat
6T27	1.11	Structure of Human Aldose Reductase Mutant L301A with a Citrate Molecule Bound in the Anion Binding Pocket
2FZD	1.08	Human aldose reductase complexed with tolrestat at 1.08 A resolution.
3V36	2.0	Aldose reductase complexed with glceraldehyde
1T41	1.05	Crystal structure of human aldose reductase complexed with NADP and IDD552
3LEN	1.21	Human Aldose Reductase mutant T113S complexed with Zopolrestat
2IQ0	1.95	Crystal Structure of Aldose Reductase complexed with Hexanoic Acid
1Z3N	1.04	Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom
2PDY	1.65	Human aldose reductase double mutant S302R-C303D complexed with fidarestat.
1ADS	1.65	AN UNLIKELY SUGAR SUBSTRATE SITE IN THE 1.65 ANGSTROMS STRUCTURE OF THE HUMAN ALDOSE REDUCTASE HOLOENZYME IMPLICATED IN DIABETIC COMPLICATIONS
1ABN	2.4	THE CRYSTAL STRUCTURE OF THE ALDOSE REDUCTASE NADPH BINARY COMPLEX

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process
Biological Process	GO:0005975	carbohydrate metabolic process
Biological Process	GO:0071475	cellular hyperosmotic salinity response
Biological Process	GO:0044597	daunorubicin metabolic process
Biological Process	GO:0044598	doxorubicin metabolic process
Biological Process	GO:0002070	epithelial cell maturation
Biological Process	GO:0046370	fructose biosynthetic process
Biological Process	GO:0072205	metanephric collecting duct development
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0035809	regulation of urine volume
Biological Process	GO:0003091	renal water homeostasis
Biological Process	GO:0001523	retinoid metabolic process
Molecular Function	GO:0047939	L-glucuronate reductase activity
Molecular Function	GO:0052650	NADP-retinol dehydrogenase activity
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity
Molecular Function	GO:0047655	allyl-alcohol dehydrogenase activity
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0043795	glyceraldehyde oxidoreductase activity
Molecular Function	GO:0047956	glycerol dehydrogenase NADP+ activity
Molecular Function	GO:0036130	prostaglandin H2 endoperoxidase reductase activity
Molecular Function	GO:0001758	retinal dehydrogenase activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005654	nucleoplasm

InterPro	InterPro name
IPR018170	Aldo/keto reductase, conserved site
IPR020471	Aldo-keto reductase
IPR023210	NADP-dependent oxidoreductase domain
IPR036812	NADP-dependent oxidoreductase domain superfamily

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-196108	Pregnenolone biosynthesis	Leaf	R-HSA-1430728	Metabolism
R-HSA-5652227	Fructose biosynthesis	Leaf	R-HSA-1430728	Metabolism

Tissue	Cell type	Expression level	Reliability
adrenal gland	cells in zona fasciculata	High	Enhanced
adrenal gland	cells in zona glomerulosa	High	Enhanced
adrenal gland	cells in zona reticularis	High	Enhanced
adrenal gland	glandular cells	High	Enhanced
cerebellum	Purkinje cells - cytoplasm/membrane	Medium	Enhanced
cerebellum	Purkinje cells - dendrites	Medium	Enhanced
placenta	cytotrophoblasts	Medium	Enhanced
placenta	hofbauer cells	Low	Enhanced
seminal vesicle	glandular cells	Medium	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	eccrine glands	Medium	Enhanced
skin 2	cells in basal layer	Medium	Enhanced
testis	Leydig cells	Low	Enhanced
testis	spermatogonia cells	Medium	Enhanced

Summary of P15121

Gene: AKR1B1, ALDR1, ALR2
Protein: Aldo-keto reductase family 1 member B1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P15121

Gene: AKR1B1, ALDR1, ALR2 Protein: Aldo-keto reductase family 1 member B1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: AKR1B1, ALDR1, ALR2
Protein: Aldo-keto reductase family 1 member B1