Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1BHI | STRUCTURE OF TRANSACTIVATION DOMAIN OF CRE-BP1/ATF-2, NMR, 20 STRUCTURES | |
| 1T2K | 3.0 | Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA |
| 4H36 | 3.0 | Crystal Structure of JNK3 in Complex with ATF2 Peptide |
| 6ZQS | 1.95 | Crystal structure of double-phosphorylated p38alpha with ATF2(83-102) |
| 6ZR5 | 2.699 | Crystal structure of JNK1 in complex with ATF2(19-58) |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0030509 | BMP signaling pathway |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0007254 | JNK cascade |
| Biological Process | GO:0001865 | NK T cell differentiation |
| Biological Process | GO:0021742 | abducens nucleus development |
| Biological Process | GO:0060612 | adipose tissue development |
| Biological Process | GO:0097186 | amelogenesis |
| Biological Process | GO:1902742 | apoptotic process involved in development |
| Biological Process | GO:0003360 | brainstem development |
| Biological Process | GO:0044255 | cellular lipid metabolic process |
| Biological Process | GO:0072740 | cellular response to anisomycin |
| Biological Process | GO:1990253 | cellular response to leucine starvation |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0098586 | cellular response to virus |
| Biological Process | GO:0060245 | detection of cell density |
| Biological Process | GO:0021754 | facial nucleus development |
| Biological Process | GO:0003418 | growth plate cartilage chondrocyte differentiation |
| Biological Process | GO:0003419 | growth plate cartilage chondrocyte proliferation |
| Biological Process | GO:0002244 | hematopoietic progenitor cell differentiation |
| Biological Process | GO:0097284 | hepatocyte apoptotic process |
| Biological Process | GO:0021743 | hypoglossal nucleus development |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:1990144 | intrinsic apoptotic signaling pathway in response to hypoxia |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0031573 | mitotic intra-S DNA damage checkpoint signaling |
| Biological Process | GO:0097049 | motor neuron apoptotic process |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060052 | neurofilament cytoskeleton organization |
| Biological Process | GO:0003151 | outflow tract morphogenesis |
| Biological Process | GO:0038066 | p38MAPK cascade |
| Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
| Biological Process | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| Biological Process | GO:0110024 | positive regulation of cardiac muscle myoblast proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1902110 | positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| Biological Process | GO:0032915 | positive regulation of transforming growth factor beta2 production |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0014070 | response to organic cyclic compound |
| Biological Process | GO:0006970 | response to osmotic stress |
| Biological Process | GO:0009414 | response to water deprivation |
| Biological Process | GO:0045815 | transcription initiation-coupled chromatin remodeling |
| Biological Process | GO:0007033 | vacuole organization |
| Biological Process | GO:0050872 | white fat cell differentiation |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0035497 | cAMP response element binding |
| Molecular Function | GO:0008140 | cAMP response element binding protein binding |
| Molecular Function | GO:0000987 | cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0044013 | histone H2B acetyltransferase activity |
| Molecular Function | GO:0010485 | histone H4 acetyltransferase activity |
| Molecular Function | GO:0004402 | histone acetyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0043522 | leucine zipper domain binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Cellular Component | GO:0016602 | CCAAT-binding factor complex |
| Cellular Component | GO:1902562 | H4 histone acetyltransferase complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035861 | site of double-strand break |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis | Leaf | R-HSA-1852241 | Organelle biogenesis and maintenance |
| R-HSA-3214847 | HATs acetylate histones | Leaf | R-HSA-4839726 | Chromatin organization |
| R-HSA-400253 | Circadian Clock | Root | R-HSA-400253 | Circadian Clock |
| R-HSA-450341 | Activation of the AP-1 family of transcription factors | Leaf | R-HSA-168256 | Immune System |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-8943724 | Regulation of PTEN gene transcription | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9018519 | Estrogen-dependent gene expression | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9031628 | NGF-stimulated transcription | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-9707616 | Heme signaling | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Supported |
| adrenal gland | glandular cells | High | Supported |
| bone marrow | hematopoietic cells | High | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | High | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | glial cells | Medium | Supported |
| caudate | neuronal cells | Low | Supported |
| cerebellum | Bergmann glia - nucleus | High | Supported |
| cerebellum | GLUC cells - nucleus | High | Supported |
| cerebellum | Purkinje cells - nucleus | High | Supported |
| cerebellum | granular cells - nucleus | High | Supported |
| cerebellum | molecular layer cells - nucleus | High | Supported |
| cerebellum | white matter cells - nucleus | High | Supported |
| cerebral cortex | endothelial cells | Medium | Supported |
| cerebral cortex | glial cells | Medium | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cervix | glandular cells | Medium | Supported |
| cervix | squamous epithelial cells | Low | Supported |
| colon | endothelial cells | Low | Supported |
| colon | glandular cells | Medium | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Medium | Supported |
| endometrium 1 | glandular cells | High | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | Medium | Supported |
| esophagus | squamous epithelial cells | Medium | Supported |
| fallopian tube | glandular cells | Medium | Supported |
| gallbladder | glandular cells | Medium | Supported |
| heart muscle | cardiomyocytes | Low | Supported |
| hippocampus | glial cells | Low | Supported |
| hippocampus | neuronal cells | High | Supported |
| kidney | cells in glomeruli | Low | Supported |
| kidney | cells in tubules | Medium | Supported |
| liver | cholangiocytes | Medium | Supported |
| liver | hepatocytes | Medium | Supported |
| lung | alveolar cells type I | Medium | Supported |
| lung | alveolar cells type II | Medium | Supported |
| lung | endothelial cells | Medium | Supported |
| lung | macrophages | Medium | Supported |
| lymph node | germinal center cells | Medium | Supported |
| lymph node | non-germinal center cells | Medium | Supported |
| nasopharynx | respiratory epithelial cells | Medium | Supported |
| oral mucosa | squamous epithelial cells | Low | Supported |
| ovary | ovarian stroma cells | Medium | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | High | Supported |
| parathyroid gland | glandular cells | Medium | Supported |
| placenta | decidual cells | High | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | High | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | High | Supported |
| seminal vesicle | glandular cells | Medium | Supported |
| skin 1 | fibroblasts | Medium | Supported |
| skin 1 | keratinocytes | Low | Supported |
| skin 1 | melanocytes | Medium | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | glandular cells | Medium | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 1 | fibroblasts | Medium | Supported |
| soft tissue 1 | peripheral nerve | Low | Supported |
| soft tissue 2 | fibroblasts | Low | Supported |
| spleen | cells in red pulp | Medium | Supported |
| spleen | cells in white pulp | Medium | Supported |
| stomach 1 | glandular cells | Low | Supported |
| stomach 2 | glandular cells | Low | Supported |
| testis | Leydig cells | Medium | Supported |
| testis | sertoli cells | Medium | Supported |
| thyroid gland | glandular cells | High | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| tonsil | squamous epithelial cells | Low | Supported |
| urinary bladder | urothelial cells | Medium | Supported |
| vagina | squamous epithelial cells | Low | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|