Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.1.1.-
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
1.1.1.141
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
15-hydroxyprostaglandin dehydrogenase (NAD+)
1.1.1.232
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor;
15-hydroxyicosatetraenoate dehydrogenase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2GDZ | 1.65 | Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+ |
| 8CVN | 2.4 | Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415 |
| 8CWL | 2.9 | Cryo-EM structure of Human 15-PGDH in complex with small molecule SW222746 |
| 8FD8 | 3.3 | human 15-PGDH with NADH bound |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0097070 | ductus arteriosus closure |
| Biological Process | GO:0007565 | female pregnancy |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0019372 | lipoxygenase pathway |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:0030728 | ovulation |
| Biological Process | GO:0007567 | parturition |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:1905828 | regulation of prostaglandin catabolic process |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0070493 | thrombin-activated receptor signaling pathway |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Molecular Function | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0070403 | NAD+ binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0004957 | prostaglandin E receptor activity |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2142700 | Synthesis of Lipoxins (LX) | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9018676 | Biosynthesis of D-series resolvins | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9018896 | Biosynthesis of E-series 18(S)-resolvins | Leaf | R-HSA-1430728 | Metabolism |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000218 | High palate |
| HP:0000239 | Large fontanelles |
| HP:0000280 | Coarse facial features |
| HP:0000508 | Ptosis |
| HP:0000767 | Pectus excavatum |
| HP:0000771 | Gynecomastia |
| HP:0000845 | Elevated circulating growth hormone concentration |
| HP:0000890 | Long clavicles |
| HP:0000929 | Abnormal skull morphology |
| HP:0000938 | Osteopenia |
| HP:0000939 | Osteoporosis |
| HP:0000951 | Abnormality of the skin |
| HP:0000964 | Eczema |
| HP:0000969 | Edema |
| HP:0000972 | Palmoplantar hyperkeratosis |
| HP:0000975 | Hyperhidrosis |
| HP:0000976 | Eczematoid dermatitis |
| HP:0000982 | Palmoplantar keratoderma |
| HP:0001051 | Seborrheic dermatitis |
| HP:0001061 | Acne |
| HP:0001070 | Mottled pigmentation |
| HP:0001072 | Thickened skin |
| HP:0001217 | Clubbing |
| HP:0001231 | Abnormal fingernail morphology |
| HP:0001369 | Arthritis |
| HP:0001376 | Limitation of joint mobility |
| HP:0001386 | Joint swelling |
| HP:0001387 | Joint stiffness |
| HP:0001500 | Broad finger |
| HP:0001519 | Disproportionate tall stature |
| HP:0001582 | Redundant skin |
| HP:0001643 | Patent ductus arteriosus |
| HP:0001744 | Splenomegaly |
| HP:0001795 | Hyperconvex nail |
| HP:0001805 | Onychogryposis |
| HP:0001821 | Broad nail |
| HP:0001837 | Broad toe |
| HP:0001903 | Anemia |
| HP:0002024 | Malabsorption |
| HP:0002164 | Nail dysplasia |
| HP:0002239 | Gastrointestinal hemorrhage |
| HP:0002240 | Hepatomegaly |
| HP:0002645 | Wormian bones |
| HP:0002650 | Scoliosis |
| HP:0002653 | Bone pain |
| HP:0002684 | Thickened calvaria |
| HP:0002754 | Osteomyelitis |
| HP:0002758 | Osteoarthritis |
| HP:0002797 | Osteolysis |
| HP:0002815 | Abnormality of the knee |
| HP:0002829 | Arthralgia |
| HP:0002970 | Genu varum |
| HP:0002992 | Abnormality of tibia morphology |
| HP:0003040 | Arthropathy |
| HP:0003103 | Abnormal cortical bone morphology |
| HP:0003549 | Abnormality of connective tissue |
| HP:0003577 | Congenital onset |
| HP:0004097 | Deviation of finger |
| HP:0004398 | Peptic ulcer |
| HP:0005561 | Abnormality of bone marrow cell morphology |
| HP:0005930 | Abnormal epiphysis morphology |
| HP:0008069 | Neoplasm of the skin |
| HP:0008391 | Dystrophic fingernails |
| HP:0009771 | Osteolytic defects of the phalanges of the hand |
| HP:0010541 | Cutis gyrata of scalp |
| HP:0010720 | Abnormal hair pattern |
| HP:0010783 | Erythema |
| HP:0010829 | Impaired temperature sensation |
| HP:0010885 | Avascular necrosis |
| HP:0011300 | Broad fingertip |
| HP:0011304 | Broad thumb |
| HP:0011362 | Abnormal hair quantity |
| HP:0012203 | Onychomycosis |
| HP:0031284 | Flushing |
| HP:0100021 | Cerebral palsy |
| HP:0100526 | Neoplasm of the lung |
| HP:0100759 | Clubbing of fingers |
| HP:0100760 | Clubbing of toes |
| HP:0200055 | Small hand |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Low | Enhanced |
| appendix | endocrine cells | Medium | Enhanced |
| appendix | enterocytes | Medium | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| bronchus | respiratory epithelial cells | Low | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| colon | endocrine cells | Medium | Enhanced |
| colon | enterocytes | Medium | Enhanced |
| duodenum | endocrine cells | Low | Enhanced |
| duodenum | enterocytes | Low | Enhanced |
| duodenum | paneth cells | High | Enhanced |
| endometrium 1 | cells in endometrial stroma | Low | Enhanced |
| endometrium 1 | glandular cells | Low | Enhanced |
| endometrium 2 | glandular cells | Low | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| fallopian tube | glandular cells | Low | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | cells in tubules | Low | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| liver | hepatocytes | Low | Enhanced |
| lung | endothelial cells | High | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Low | Enhanced |
| lymph node | non-germinal center cells | Low | Enhanced |
| ovary | follicle cells | Low | Enhanced |
| placenta | decidual cells | Low | Enhanced |
| placenta | trophoblastic cells | Low | Enhanced |
| rectum | endocrine cells | Medium | Enhanced |
| rectum | enterocytes | Medium | Enhanced |
| rectum | mucosal lymphoid cells | Medium | Enhanced |
| skin 1 | fibrohistiocytic cells | High | Enhanced |
| skin 2 | fibrohistiocytic cells | Low | Enhanced |
| small intestine | paneth cells | High | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| spleen | cells in white pulp | Low | Enhanced |
| stomach 1 | glandular cells | High | Enhanced |
| stomach 2 | glandular cells | High | Enhanced |
| tonsil | germinal center cells | Low | Enhanced |
| tonsil | non-germinal center cells | Low | Enhanced |
| tonsil | squamous epithelial cells | Low | Enhanced |
| urinary bladder | urothelial cells | High | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| isolated congenital digital clubbing | MONDO:0007343 | Q68 | chapter17, Congenital malformations, deformations and chromosomal abnormalities | OMIM:119900 | Orphanet:217059 |
| obsolete pachydermoperiostosis | MONDO:0009799 | M89 | chapter13, Diseases of the musculoskeletal system and connective tissue | ||
| cranio-osteoarthropathy | MONDO:0015466 | M89 | chapter13, Diseases of the musculoskeletal system and connective tissue | Orphanet:1525 | |
| hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | MONDO:0024546 | M89 | chapter13, Diseases of the musculoskeletal system and connective tissue | OMIM:259100 | Orphanet:1525 |