Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.4.6
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor;
nucleoside-diphosphate kinase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1JXV | 2.2 | Crystal Structure of Human Nucleoside Diphosphate Kinase A |
| 1UCN | 2.0 | X-ray structure of human nucleoside diphosphate kinase A complexed with ADP at 2 A resolution |
| 2HVD | 2.15 | Human nucleoside diphosphate kinase A complexed with ADP |
| 2HVE | 2.402 | S120G mutant of human nucleoside diphosphate kinase A complexed with ADP |
| 3L7U | 2.1 | Crystal structure of human NM23-H1 |
| 4ENO | 2.8 | Crystal structure of oxidized human nm23-H1 |
| 5UI4 | 2.75 | Structure of NME1 covalently conjugated to imidazole fluorosulfate |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006241 | CTP biosynthetic process |
| Biological Process | GO:0006183 | GTP biosynthetic process |
| Biological Process | GO:0006228 | UTP biosynthetic process |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0016310 | phosphorylation |
| Biological Process | GO:0043388 | positive regulation of DNA binding |
| Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004536 | DNA nuclease activity |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0004550 | nucleoside diphosphate kinase activity |
| Molecular Function | GO:0043024 | ribosomal small subunit binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032587 | ruffle membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-9748787 | Azathioprine ADME | Leaf | R-HSA-9748784 | Drug ADME |
| R-HSA-9755088 | Ribavirin ADME | Leaf | R-HSA-9748784 | Drug ADME |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:16442775 |
| Nucleus | ECO:0000269 | PubMed:16442775 |