Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.4.6
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor;
nucleoside-diphosphate kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
1JXV | 2.2 | Crystal Structure of Human Nucleoside Diphosphate Kinase A |
1UCN | 2.0 | X-ray structure of human nucleoside diphosphate kinase A complexed with ADP at 2 A resolution |
2HVD | 2.15 | Human nucleoside diphosphate kinase A complexed with ADP |
2HVE | 2.402 | S120G mutant of human nucleoside diphosphate kinase A complexed with ADP |
3L7U | 2.1 | Crystal structure of human NM23-H1 |
4ENO | 2.8 | Crystal structure of oxidized human nm23-H1 |
5UI4 | 2.75 | Structure of NME1 covalently conjugated to imidazole fluorosulfate |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006241 | CTP biosynthetic process |
Biological Process | GO:0006183 | GTP biosynthetic process |
Biological Process | GO:0006228 | UTP biosynthetic process |
Biological Process | GO:0030154 | cell differentiation |
Biological Process | GO:0006897 | endocytosis |
Biological Process | GO:0007595 | lactation |
Biological Process | GO:0008285 | negative regulation of cell population proliferation |
Biological Process | GO:0007399 | nervous system development |
Biological Process | GO:0016310 | phosphorylation |
Biological Process | GO:0043388 | positive regulation of DNA binding |
Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
Biological Process | GO:0042981 | regulation of apoptotic process |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0004536 | DNA nuclease activity |
Molecular Function | GO:0005525 | GTP binding |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0000287 | magnesium ion binding |
Molecular Function | GO:0004550 | nucleoside diphosphate kinase activity |
Molecular Function | GO:0043024 | ribosomal small subunit binding |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0032587 | ruffle membrane |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-499943 | Interconversion of nucleotide di- and triphosphates | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-9748787 | Azathioprine ADME | Leaf | R-HSA-9748784 | Drug ADME |
R-HSA-9755088 | Ribavirin ADME | Leaf | R-HSA-9748784 | Drug ADME |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:16442775 |
Nucleus | ECO:0000269 | PubMed:16442775 |