Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
1.6.5.2
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor;
NAD(P)H dehydrogenase (quinone)
PDB | Resolution (Å) | PDB name |
---|---|---|
1D4A | 1.7 | CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AT 1.7 A RESOLUTION |
1DXO | 2.5 | Crystal structure of human NAD[P]H-QUINONE oxidoreductase CO with 2,3,5,6,tetramethyl-P-benzoquinone (duroquinone) at 2.5 Angstrom resolution |
1GG5 | 2.5 | CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION |
1H66 | 2.0 | CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE CO WITH 2,5-diaziridinyl-3-hydroxyl-6-methyl-1,4-benzoquinone |
1H69 | 1.86 | CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE CO WITH 2,3,5,6,TETRAMETHYL-P-BENZOQUINONE (DUROQUINONE) AT 2.5 ANGSTROM RESOLUTION |
1KBO | 2.3 | Complex of Human recombinant NAD(P)H:Quinone Oxide reductase type 1 with 5-methoxy-1,2-dimethyl-3-(phenoxymethyl)indole-4,7-dione (ES1340) |
1KBQ | 1.8 | Complex of Human NAD(P)H quinone Oxidoreductase with 5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione (ES936) |
1QBG | 2.3 | CRYSTAL STRUCTURE OF HUMAN DT-DIAPHORASE (NAD(P)H OXIDOREDUCTASE) |
2F1O | 2.75 | Crystal Structure of NQO1 with Dicoumarol |
3JSX | 2.45 | X-ray Crystal structure of NAD(P)H: Quinone Oxidoreductase-1 (NQO1) bound to the coumarin-based inhibitor AS1 |
4CET | 2.2 | Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with dicoumarol at 2.2 A resolution |
4CF6 | 2.694 | Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with Cibacron blue at 2.7 A resolution |
5A4K | 2.093 | Crystal structure of the R139W variant of human NAD(P)H:quinone oxidoreductase |
5EA2 | 2.01 | Crystal Structure of Holo NAD(P)H dehydrogenase, quinone 1 |
5EAI | 2.9 | Crystal Structure of NAD(P)H dehydrogenase, quinone 1 complexed with a chemotherapeutic naphthoquinone E6a |
5FUQ | 2.04 | CRYSTAL STRUCTURE OF THE H80R VARIANT OF NQO1 BOUND TO DICOUMAROL |
6FY4 | 2.76 | Structure of human NAD(P) H:quinone oxidoreductase in complex with N-(2-bromophenyl)pyrrolidine-1-sulfonamide |
6LLC | 2.501 | Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006116 | NADH oxidation |
Biological Process | GO:0070995 | NADPH oxidation |
Biological Process | GO:0007568 | aging |
Biological Process | GO:0045454 | cell redox homeostasis |
Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
Biological Process | GO:0071248 | cellular response to metal ion |
Biological Process | GO:0034599 | cellular response to oxidative stress |
Biological Process | GO:0045087 | innate immune response |
Biological Process | GO:0043066 | negative regulation of apoptotic process |
Biological Process | GO:0043086 | negative regulation of catalytic activity |
Biological Process | GO:0042177 | negative regulation of protein catabolic process |
Biological Process | GO:0006809 | nitric oxide biosynthetic process |
Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
Biological Process | GO:0030163 | protein catabolic process |
Biological Process | GO:0000209 | protein polyubiquitination |
Biological Process | GO:0019430 | removal of superoxide radicals |
Biological Process | GO:1904844 | response to L-glutamine |
Biological Process | GO:0043279 | response to alkaloid |
Biological Process | GO:0014075 | response to amine |
Biological Process | GO:0009743 | response to carbohydrate |
Biological Process | GO:0051602 | response to electrical stimulus |
Biological Process | GO:0032355 | response to estradiol |
Biological Process | GO:0045471 | response to ethanol |
Biological Process | GO:1905395 | response to flavonoid |
Biological Process | GO:0009725 | response to hormone |
Biological Process | GO:1904880 | response to hydrogen sulfide |
Biological Process | GO:0002931 | response to ischemia |
Biological Process | GO:0032496 | response to lipopolysaccharide |
Biological Process | GO:0007584 | response to nutrient |
Biological Process | GO:0006979 | response to oxidative stress |
Biological Process | GO:0033574 | response to testosterone |
Biological Process | GO:1904772 | response to tetrachloromethane |
Biological Process | GO:0009636 | response to toxic substance |
Biological Process | GO:0007271 | synaptic transmission, cholinergic |
Biological Process | GO:0006743 | ubiquinone metabolic process |
Biological Process | GO:0042360 | vitamin E metabolic process |
Biological Process | GO:0042373 | vitamin K metabolic process |
Biological Process | GO:0006805 | xenobiotic metabolic process |
Molecular Function | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity |
Molecular Function | GO:0050136 | NADH dehydrogenase (quinone) activity |
Molecular Function | GO:0008753 | NADPH dehydrogenase (quinone) activity |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0004784 | superoxide dismutase activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0030425 | dendrite |
Cellular Component | GO:0043025 | neuronal cell body |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0045202 | synapse |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-350562 | Regulation of ornithine decarboxylase (ODC) | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-9818027 | NFE2L2 regulating anti-oxidant/detoxification enzymes | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm, cytosol | ECO:0000250 |