MultifacetedProtDB - Bologna Biocomputing Group

Summary of P16050

Gene: ALOX15, LOG15
Protein: Polyunsaturated fatty acid lipoxygenase ALOX15

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
1.13.11.-	Oxidoreductases; Acting on single donors with incorporation of molecular oxygen (oxygenases); With incorporation of two atoms of oxygen;
1.13.11.12	Oxidoreductases; Acting on single donors with incorporation of molecular oxygen (oxygenases); With incorporation of two atoms of oxygen; linoleate 13S-lipoxygenase
1.13.11.31	Oxidoreductases; Acting on single donors with incorporation of molecular oxygen (oxygenases); With incorporation of two atoms of oxygen; arachidonate 12-lipoxygenase
1.13.11.33	Oxidoreductases; Acting on single donors with incorporation of molecular oxygen (oxygenases); With incorporation of two atoms of oxygen; arachidonate 15-lipoxygenase

Publications

Structure

GO term

GO ontology	GO term	GO description
Biological Process	GO:0043277	apoptotic cell clearance
Biological Process	GO:0019369	arachidonic acid metabolic process
Biological Process	GO:0030282	bone mineralization
Biological Process	GO:0071277	cellular response to calcium ion
Biological Process	GO:0035963	cellular response to interleukin-13
Biological Process	GO:0019395	fatty acid oxidation
Biological Process	GO:0051122	hepoxilin biosynthetic process
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0043651	linoleic acid metabolic process
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0034440	lipid oxidation
Biological Process	GO:2001303	lipoxin A4 biosynthetic process
Biological Process	GO:0019372	lipoxygenase pathway
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process
Biological Process	GO:0002820	negative regulation of adaptive immune response
Biological Process	GO:0001503	ossification
Biological Process	GO:0006646	phosphatidylethanolamine biosynthetic process
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0030838	positive regulation of actin filament polymerization
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion
Biological Process	GO:1901074	regulation of engulfment of apoptotic cell
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway
Biological Process	GO:0034976	response to endoplasmic reticulum stress
Biological Process	GO:0042060	wound healing
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
Cellular Component	GO:0005811	lipid droplet
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane

InterPro / Pfam

InterPro	InterPro name
IPR000907	Lipoxygenase
IPR001024	PLAT/LH2 domain
IPR001885	Lipoxygenase, mammalian
IPR013819	Lipoxygenase, C-terminal
IPR020833	Lipoxygenase, iron binding site
IPR020834	Lipoxygenase, conserved site
IPR036226	Lipoxigenase, C-terminal domain superfamily
IPR036392	PLAT/LH2 domain superfamily
IPR042062	Lipoxygenase, vertebrates, PLAT domain

Pfam	Pfam name
PF00305	Lipoxygenase
PF01477	PLAT/LH2 domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	Leaf	R-HSA-1430728	Metabolism
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	Leaf	R-HSA-168256	Immune System
R-HSA-9018677	Biosynthesis of DHA-derived SPMs	Internal node	R-HSA-1430728	Metabolism
R-HSA-9018681	Biosynthesis of protectins	Leaf	R-HSA-1430728	Metabolism
R-HSA-9018896	Biosynthesis of E-series 18(S)-resolvins	Leaf	R-HSA-1430728	Metabolism
R-HSA-9023661	Biosynthesis of E-series 18(R)-resolvins	Leaf	R-HSA-1430728	Metabolism
R-HSA-9025106	Biosynthesis of DPAn-6 SPMs	Leaf	R-HSA-1430728	Metabolism
R-HSA-9026286	Biosynthesis of DPAn-3-derived protectins and resolvins	Leaf	R-HSA-1430728	Metabolism

Subcellular location

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:17052953
Cell membrane	ECO:0000269	PubMed:21831839
Cytoplasm, cytosol	ECO:0000269	PubMed:17052953
Cytoplasm, cytosol	ECO:0000269	PubMed:21831839
Lipid droplet	ECO:0000269	PubMed:19528634

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
bone marrow	hematopoietic cells	Medium	Approved
fallopian tube	glandular cells	Medium	Approved
lung	macrophages	Low	Approved
lymph node	non-germinal center cells	Medium	Approved
nasopharynx	basal cells	High	Approved
nasopharynx	ciliated cells (cell body)	High	Approved
nasopharynx	ciliated cells (cilia axoneme)	High	Approved
nasopharynx	ciliated cells (ciliary rootlets)	High	Approved
nasopharynx	ciliated cells (tip of cilia)	High	Approved
nasopharynx	goblet cells	High	Approved
spleen	cells in red pulp	Medium	Approved
testis	Leydig cells	Low	Approved
testis	elongated or late spermatids	Low	Approved
testis	round or early spermatids	High	Approved
tonsil	non-germinal center cells	Medium	Approved

Summary of P16050

Gene: ALOX15, LOG15 Protein: Polyunsaturated fatty acid lipoxygenase ALOX15

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ALOX15, LOG15
Protein: Polyunsaturated fatty acid lipoxygenase ALOX15