MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2EZD		SOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE
2EZE		SOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, 35 STRUCTURES
2EZF		SOLUTION STRUCTURE OF A COMPLEX OF THE THIRD DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE
2EZG		SOLUTION STRUCTURE OF A COMPLEX OF THE THIRD DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, 35 STRUCTURES

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006268	DNA unwinding involved in DNA replication
Biological Process	GO:0006284	base-excision repair
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0006337	nucleosome disassembly
Biological Process	GO:0090402	oncogene-induced cell senescence
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006355	regulation of DNA-templated transcription
Molecular Function	GO:0051575	5'-deoxyribose-5-phosphate lyase activity
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0008301	DNA binding, bending
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0003680	minor groove of adenine-thymine-rich DNA binding
Molecular Function	GO:0060090	molecular adaptor activity
Molecular Function	GO:0140677	molecular function activator activity
Molecular Function	GO:0030374	nuclear receptor coactivator activity
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding
Molecular Function	GO:0046965	nuclear retinoid X receptor binding
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding
Molecular Function	GO:0030527	structural constituent of chromatin
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0003712	transcription coregulator activity
Molecular Function	GO:0001221	transcription coregulator binding
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0035985	senescence-associated heterochromatin focus
Cellular Component	GO:0005667	transcription regulator complex

InterPro / Pfam

InterPro	InterPro name
IPR000116	High mobility group protein HMGA
IPR000637	HMG-I/HMG-Y, DNA-binding, conserved site
IPR017956	AT hook, DNA-binding motif

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-162592	Integration of provirus	Internal node	R-HSA-1643685	Disease
R-HSA-164843	2-LTR circle formation	Leaf	R-HSA-1643685	Disease
R-HSA-175567	Integration of viral DNA into host genomic DNA	Leaf	R-HSA-1643685	Disease
R-HSA-177539	Autointegration results in viral DNA circles	Leaf	R-HSA-1643685	Disease
R-HSA-180689	APOBEC3G mediated resistance to HIV-1 infection	Leaf	R-HSA-1643685	Disease
R-HSA-180910	Vpr-mediated nuclear import of PICs	Leaf	R-HSA-1643685	Disease
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Leaf	R-HSA-8953897	Cellular responses to stimuli

Subcellular location

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000855	Insulin resistance
HP:0003584	Late onset
HP:0005978	Type II diabetes mellitus
HP:0031819	Increased waist to hip ratio

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Enhanced
appendix	endocrine cells	High	Enhanced
appendix	enterocytes	Medium	Enhanced
appendix	goblet cells	High	Enhanced
appendix	non-germinal center cells	High	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	glandular cells	High	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
caudate	glial cells	High	Enhanced
cerebellum	granular cells - nucleus	High	Enhanced
cerebellum	molecular layer cells - nucleus	High	Enhanced
cerebellum	white matter cells - nucleus	High	Enhanced
cerebral cortex	glial cells	High	Enhanced
cerebral cortex	neuronal cells	High	Enhanced
cervix	glandular cells	Medium	Enhanced
cervix	squamous epithelial cells	Medium	Enhanced
colon	endocrine cells	High	Enhanced
colon	enterocytes	High	Enhanced
colon	goblet cells	High	Enhanced
colon	mucosal lymphoid cells	High	Enhanced
duodenum	endocrine cells	High	Enhanced
duodenum	enterocytes	High	Enhanced
duodenum	glands of Brunner	High	Enhanced
duodenum	goblet cells	High	Enhanced
duodenum	paneth cells	High	Enhanced
endometrium 1	glandular cells	Medium	Enhanced
endometrium 2	glandular cells	High	Enhanced
epididymis	glandular cells	High	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
fallopian tube	glandular cells	High	Enhanced
gallbladder	glandular cells	Medium	Enhanced
heart muscle	cardiomyocytes	Medium	Enhanced
hippocampus	glial cells	High	Enhanced
hippocampus	neuronal cells	Medium	Enhanced
kidney	bowman's capsule	Low	Enhanced
kidney	cells in glomeruli	Low	Enhanced
kidney	collecting ducts	High	Enhanced
kidney	distal tubules	High	Enhanced
kidney	proximal tubules (cell body)	Medium	Enhanced
liver	cholangiocytes	Medium	Enhanced
liver	hepatocytes	Low	Enhanced
lung	alveolar cells type I	High	Enhanced
lung	alveolar cells type II	High	Enhanced
lung	macrophages	High	Enhanced
lymph node	non-germinal center cells	High	Enhanced
nasopharynx	respiratory epithelial cells	High	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
pancreas	pancreatic endocrine cells	Medium	Enhanced
parathyroid gland	glandular cells	High	Enhanced
placenta	decidual cells	Medium	Enhanced
placenta	trophoblastic cells	High	Enhanced
prostate	glandular cells	High	Enhanced
rectum	endocrine cells	High	Enhanced
rectum	enterocytes	High	Enhanced
rectum	goblet cells	High	Enhanced
rectum	mucosal lymphoid cells	High	Enhanced
salivary gland	glandular cells	High	Enhanced
seminal vesicle	glandular cells	High	Enhanced
skeletal muscle	myocytes	Medium	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	cells in granular layer	High	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 1	endothelial cells	Low	Enhanced
skin 1	hair follicles	Medium	Enhanced
skin 1	langerhans cells	Medium	Enhanced
skin 1	lymphocytes	High	Enhanced
skin 1	melanocytes	High	Enhanced
skin 2	cells in basal layer	Medium	Enhanced
skin 2	cells in granular layer	High	Enhanced
skin 2	cells in spinous layer	Medium	Enhanced
skin 2	endothelial cells	Low	Enhanced
skin 2	langerhans cells	Medium	Enhanced
skin 2	lymphocytes	High	Enhanced
skin 2	melanocytes	High	Enhanced
small intestine	endocrine cells	High	Enhanced
small intestine	enterocytes	High	Enhanced
small intestine	goblet cells	High	Enhanced
small intestine	paneth cells	High	Enhanced
smooth muscle	smooth muscle cells	Low	Enhanced
soft tissue 2	peripheral nerve	High	Enhanced
spleen	cells in red pulp	High	Enhanced
spleen	cells in white pulp	High	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced
testis	pachytene spermatocytes	High	Enhanced
testis	preleptotene spermatocytes	High	Enhanced
testis	round or early spermatids	High	Enhanced
testis	spermatogonia cells	High	Enhanced
thyroid gland	glandular cells	High	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	High	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
urinary bladder	urothelial cells	High	Enhanced
vagina	squamous epithelial cells	Medium	Enhanced

Disease

Location	ECO term	Pubmed
Chromosome
Nucleus

Summary of P17096

Gene: HMGA1, HMGIY
Protein: High mobility group protein HMG-I/HMG-Y

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P17096

Gene: HMGA1, HMGIY Protein: High mobility group protein HMG-I/HMG-Y

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: HMGA1, HMGIY
Protein: High mobility group protein HMG-I/HMG-Y