Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.6.1.1
Transferases;
Transferring nitrogenous groups;
Transaminases;
aspartate transaminase
2.6.1.3
Transferases;
Transferring nitrogenous groups;
Transaminases;
cysteine transaminase
PDB | Resolution (Å) | PDB name |
---|---|---|
3II0 | 2.05 | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) |
3WZF | 2.991 | Crystal structure of human cytoplasmic aspartate aminotransferase |
6DNA | 3.0 | Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) |
6DNB | 1.7 | Crystal structure of T110A:S256A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) |
6DND | 2.1 | Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1) |
6LIG | 2.62 | Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1) in complex with AH |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006103 | 2-oxoglutarate metabolic process |
Biological Process | GO:0007219 | Notch signaling pathway |
Biological Process | GO:0006532 | aspartate biosynthetic process |
Biological Process | GO:0006533 | aspartate catabolic process |
Biological Process | GO:0006531 | aspartate metabolic process |
Biological Process | GO:0032869 | cellular response to insulin stimulus |
Biological Process | GO:0055089 | fatty acid homeostasis |
Biological Process | GO:0006094 | gluconeogenesis |
Biological Process | GO:0019551 | glutamate catabolic process to 2-oxoglutarate |
Biological Process | GO:0019550 | glutamate catabolic process to aspartate |
Biological Process | GO:0006536 | glutamate metabolic process |
Biological Process | GO:0006114 | glycerol biosynthetic process |
Biological Process | GO:0006107 | oxaloacetate metabolic process |
Biological Process | GO:0051384 | response to glucocorticoid |
Molecular Function | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity |
Molecular Function | GO:0047801 | L-cysteine transaminase activity |
Molecular Function | GO:0004609 | phosphatidylserine decarboxylase activity |
Molecular Function | GO:0030170 | pyridoxal phosphate binding |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0005634 | nucleus |
InterPro | InterPro name |
---|---|
IPR000796 | Aspartate/other aminotransferase |
IPR004838 | Aminotransferases, class-I, pyridoxal-phosphate-binding site |
IPR004839 | Aminotransferase, class I/classII |
IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
IPR015424 | Pyridoxal phosphate-dependent transferase |
Pfam | Pfam name |
---|---|
PF00155 | Aminotransferase class I and II |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-1237112 | Methionine salvage pathway | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-70263 | Gluconeogenesis | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-8963693 | Aspartate and asparagine metabolism | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:1974457 |