MultifacetedProtDB - Bologna Biocomputing Group

Summary of P17516

Gene: AKR1C4, CHDR
Protein: Aldo-keto reductase family 1 member C4

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
1.1.1.-	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor;
1.1.1.209	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3(or 17)α-hydroxysteroid dehydrogenase
1.1.1.210	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α(or 20β)-hydroxysteroid dehydrogenase
1.1.1.225	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; chlordecone reductase
1.1.1.357	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α-hydroxysteroid 3-dehydrogenase
1.1.1.51	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3(or 17)α-hydroxysteroid dehydrogenase
1.1.1.53	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α(or 20β)-hydroxysteroid dehydrogenase
1.1.1.62	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 17β-estradiol 17-dehydrogenase

Publications

Structure

PDB	Resolution (Å)	PDB name
2FVL	2.4	Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (AKR1C4) complexed with NADP+

GO term

GO ontology	GO term	GO description
Biological Process	GO:0008209	androgen metabolic process
Biological Process	GO:0015721	bile acid and bile salt transport
Biological Process	GO:0006699	bile acid biosynthetic process
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus
Biological Process	GO:0044597	daunorubicin metabolic process
Biological Process	GO:0044598	doxorubicin metabolic process
Biological Process	GO:0042448	progesterone metabolic process
Biological Process	GO:0006693	prostaglandin metabolic process
Biological Process	GO:0001523	retinoid metabolic process
Biological Process	GO:0008202	steroid metabolic process
Molecular Function	GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity
Molecular Function	GO:0047024	5alpha-androstane-3beta,17beta-diol dehydrogenase activity
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity
Molecular Function	GO:0047044	androstan-3-alpha,17-beta-diol dehydrogenase activity
Molecular Function	GO:0047023	androsterone dehydrogenase activity
Molecular Function	GO:0032052	bile acid binding
Molecular Function	GO:0015125	bile acid transmembrane transporter activity
Molecular Function	GO:0047743	chlordecone reductase activity
Molecular Function	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase NAD(P) activity
Molecular Function	GO:0047086	ketosteroid monooxygenase activity
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Molecular Function	GO:0001758	retinal dehydrogenase activity
Molecular Function	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity
Molecular Function	GO:0047035	testosterone dehydrogenase (NAD+) activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome

InterPro	InterPro name
IPR018170	Aldo/keto reductase, conserved site
IPR020471	Aldo-keto reductase
IPR023210	NADP-dependent oxidoreductase domain
IPR036812	NADP-dependent oxidoreductase domain superfamily
IPR044482	Aldo-keto reductase family 1 member C

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-975634	Retinoid metabolism and transport	Leaf	R-HSA-9709957	Sensory Perception

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000037	Male pseudohermaphroditism
HP:0000062	Ambiguous genitalia
HP:0012245	Sex reversal

Summary of P17516

Gene: AKR1C4, CHDR
Protein: Aldo-keto reductase family 1 member C4

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P17516

Gene: AKR1C4, CHDR Protein: Aldo-keto reductase family 1 member C4

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: AKR1C4, CHDR
Protein: Aldo-keto reductase family 1 member C4