MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
5.4.2.11	Isomerases; Intramolecular transferases; Phosphotransferases (phosphomutases); phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.4	Isomerases; Intramolecular transferases; Phosphotransferases (phosphomutases); bisphosphoglycerate mutase

Structure

PDB	Resolution (Å)	PDB name
1YFK	2.7	Crystal structure of human B type phosphoglycerate mutase
1YJX	2.8	Crystal structure of human B type phosphoglycerate mutase
4GPI	2.0817	Crystal structure of human B type phosphoglycerate mutase
4GPZ	1.65	Crystal structure of human B type phosphoglycerate mutase H11 phosphorylated form
5Y2I	1.917	Phosphoglycerate mutase 1 (PGAM1) complexed with its inhibitor PGMI-004A
5Y2U	1.98	X-ray structure of Phosphoglycerate Mutase 1(PGAM1) complexed with a small molecule
5Y35	1.994	Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH1
5Y64	2.149	Phosphoglycerate mutase 1 H11 phosphorylated form complexed with KH1
5Y65	2.554	Phosphoglycerate mutase 1 complexed with a small molecule inhibitor KH2
5ZRM	2.28	Phosphoglycerate mutase 1 complexed with a small molecule inhibitor In-AC
5ZS8	2.2	Acetylation of lysine 100 of Phosphoglycerate mutase 1 complexed with KH_ol
6ISN	1.98	Phosphoglycerate mutase 1 complexed with a small molecule inhibitor

GO term

GO ontology	GO term	GO description
Biological Process	GO:0061621	canonical glycolysis
Biological Process	GO:0006094	gluconeogenesis
Biological Process	GO:0006096	glycolytic process
Biological Process	GO:0006110	regulation of glycolytic process
Biological Process	GO:0043456	regulation of pentose-phosphate shunt
Biological Process	GO:0045730	respiratory burst
Molecular Function	GO:0046538	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Molecular Function	GO:0004082	bisphosphoglycerate mutase activity
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0004619	phosphoglycerate mutase activity
Molecular Function	GO:0019901	protein kinase binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:1904813	ficolin-1-rich granule lumen
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0034774	secretory granule lumen

InterPro / Pfam

InterPro	InterPro name
IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site
IPR005952	Phosphoglycerate mutase 1
IPR013078	Histidine phosphatase superfamily, clade-1
IPR029033	Histidine phosphatase superfamily

Pfam	Pfam name
PF00300	Histidine phosphatase superfamily (branch 1)

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System
R-HSA-70171	Glycolysis	Internal node	R-HSA-1430728	Metabolism
R-HSA-70263	Gluconeogenesis	Leaf	R-HSA-1430728	Metabolism

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Low	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	Medium	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebellum	cells in molecular layer	Medium	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Medium	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	Low	Approved
colon	endothelial cells	Low	Approved
colon	glandular cells	Low	Approved
colon	peripheral nerve/ganglion	Low	Approved
endometrium 1	glandular cells	Low	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	glandular cells	Low	Approved
gallbladder	glandular cells	Low	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	neuronal cells	Medium	Approved
kidney	cells in tubules	High	Approved
liver	hepatocytes	Low	Approved
lung	macrophages	Low	Approved
lymph node	germinal center cells	Low	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	follicle cells	Low	Approved
pancreas	exocrine glandular cells	Low	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Low	Approved
placenta	decidual cells	Low	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Low	Approved
seminal vesicle	glandular cells	Medium	Approved
skin 1	keratinocytes	Low	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Low	Approved
smooth muscle	smooth muscle cells	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Low	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Medium	Approved

Summary of P18669

Gene: PGAM1, PGAMA, CDABP0006
Protein: Phosphoglycerate mutase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P18669

Gene: PGAM1, PGAMA, CDABP0006 Protein: Phosphoglycerate mutase 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: PGAM1, PGAMA, CDABP0006
Protein: Phosphoglycerate mutase 1