Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
1.14.17.3
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor;
peptidylglycine monooxygenase
4.3.2.5
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases;
peptidylamidoglycolate lyase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0062112 | fatty acid primary amide biosynthetic process |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0060173 | limb development |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0060135 | maternal process involved in female pregnancy |
| Biological Process | GO:0042476 | odontogenesis |
| Biological Process | GO:0022602 | ovulation cycle process |
| Biological Process | GO:0001519 | peptide amidation |
| Biological Process | GO:0018032 | protein amidation |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0050708 | regulation of protein secretion |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0046688 | response to copper ion |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0051384 | response to glucocorticoid |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0009268 | response to pH |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0010043 | response to zinc ion |
| Biological Process | GO:0009404 | toxin metabolic process |
| Molecular Function | GO:0031418 | L-ascorbic acid binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004598 | peptidylamidoglycolate lyase activity |
| Molecular Function | GO:0004504 | peptidylglycine monooxygenase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Cellular Component | GO:0030658 | transport vesicle membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000323 | Copper type II, ascorbate-dependent monooxygenase, N-terminal |
| IPR000720 | Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase |
| IPR001258 | NHL repeat |
| IPR008977 | PHM/PNGase F domain superfamily |
| IPR011042 | Six-bladed beta-propeller, TolB-like |
| IPR014783 | Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site |
| IPR014784 | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal |
| IPR020611 | Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site |
| IPR024548 | Copper type II ascorbate-dependent monooxygenase, C-terminal |
| IPR036939 | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF01082 | Copper type II ascorbate-dependent monooxygenase, N-terminal domain |
| PF01436 | NHL repeat |
| PF03712 | Copper type II ascorbate-dependent monooxygenase, C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasmic vesicle, secretory vesicle membrane | ECO:0000250 | |
| Membrane | ||
| Secreted |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Enhanced |
| appendix | endocrine cells | High | Enhanced |
| bronchus | ciliated cells (cilia axoneme) | High | Enhanced |
| bronchus | ciliated cells (ciliary rootlets) | High | Enhanced |
| bronchus | ciliated cells (tip of cilia) | High | Enhanced |
| caudate | neuronal cells | Low | Enhanced |
| cerebellum | cells in granular layer | Medium | Enhanced |
| cerebellum | cells in molecular layer | Low | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cerebral cortex | neuropil | Medium | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endocrine cells | High | Enhanced |
| colon | peripheral nerve/ganglion | Medium | Enhanced |
| duodenum | endocrine cells | High | Enhanced |
| duodenum | glands of Brunner | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | glandular cells | Low | Enhanced |
| epididymis | glandular cells | High | Enhanced |
| fallopian tube | ciliated cells (ciliary rootlets) | Medium | Enhanced |
| fallopian tube | ciliated cells (tip of cilia) | Medium | Enhanced |
| fallopian tube | non-ciliated cells | High | Enhanced |
| heart muscle | cardiomyocytes | High | Enhanced |
| hippocampus | neuronal cells | Low | Enhanced |
| kidney | cells in glomeruli | High | Enhanced |
| kidney | proximal tubules (cell body) | Medium | Enhanced |
| nasopharynx | ciliated cells (cell body) | Low | Enhanced |
| nasopharynx | ciliated cells (cilia axoneme) | High | Enhanced |
| nasopharynx | ciliated cells (ciliary rootlets) | High | Enhanced |
| nasopharynx | ciliated cells (tip of cilia) | High | Enhanced |
| oral mucosa | squamous epithelial cells | Low | Enhanced |
| pancreas | pancreatic endocrine cells | Medium | Enhanced |
| placenta | decidual cells | Low | Enhanced |
| placenta | syncytiotrophoblasts - cell body | High | Enhanced |
| rectum | endocrine cells | High | Enhanced |
| rectum | peripheral nerve/ganglion | Medium | Enhanced |
| salivary gland | glandular cells | Low | Enhanced |
| skeletal muscle | myocytes | Medium | Enhanced |
| skin 1 | cells in basal layer | Low | Enhanced |
| skin 2 | cells in granular layer | Low | Enhanced |
| small intestine | endocrine cells | High | Enhanced |
| small intestine | enterocytes - Microvilli | High | Enhanced |
| smooth muscle | smooth muscle cells | Medium | Enhanced |
| stomach 1 | glandular cells | Low | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|