MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.2.2	Transferases; Acyltransferases; Aminoacyltransferases; γ-glutamyltransferase
3.4.19.13	Hydrolases; Acting on peptide bonds (peptidases); Omega peptidases; glutathione γ-glutamate hydrolase
3.4.19.14	Hydrolases; Acting on peptide bonds (peptidases); Omega peptidases; leukotriene-C4 hydrolase

PDB	Resolution (Å)	PDB name
4GDX	1.67	Crystal Structure of Human Gamma-Glutamyl Transpeptidase--Glutamate complex
4GG2	2.21	The crystal structure of glutamate-bound human gamma-glutamyltranspeptidase 1
4Z9O	2.3	Crystal Structure of human GGT1
4ZBK	2.18	Crystal Structure of human GGT1 in complex with GGsTop inhibitor
4ZC6	2.1	Crystal Structure of human GGT1 in complex with Serine Borate
4ZCG	2.22	Crystal Structure of human GGT1 in complex with Glutamate (with all atoms of glutamate)
5V4Q	2.2	Crystal Structure of human GGT1 in complex with DON

GO ontology	GO term	GO description
Biological Process	GO:0006520	amino acid metabolic process
Biological Process	GO:0019344	cysteine biosynthetic process
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0006536	glutamate metabolic process
Biological Process	GO:0006750	glutathione biosynthetic process
Biological Process	GO:0006751	glutathione catabolic process
Biological Process	GO:1901750	leukotriene D4 biosynthetic process
Biological Process	GO:0006691	leukotriene metabolic process
Biological Process	GO:0031179	peptide modification
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0002682	regulation of immune system process
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0007283	spermatogenesis
Biological Process	GO:0031638	zymogen activation
Molecular Function	GO:0036374	glutathione hydrolase activity
Molecular Function	GO:0102953	hypoglycin A gamma-glutamyl transpeptidase activity
Molecular Function	GO:0103068	leukotriene C4 gamma-glutamyl transferase activity
Molecular Function	GO:0002951	leukotriene-C(4) hydrolase
Molecular Function	GO:0000048	peptidyltransferase activity
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005886	plasma membrane

InterPro	InterPro name
IPR000101	Gamma-glutamyltranspeptidase
IPR029055	Nucleophile aminohydrolases, N-terminal
IPR043137	Gamma-glutamyltranspeptidase, small subunit
IPR043138	Gamma-glutamyltranspeptidase, large subunit, C-terminal domain

Pfam	Pfam name
PF01019	Gamma-glutamyltranspeptidase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-174403	Glutathione synthesis and recycling	Leaf	R-HSA-1430728	Metabolism
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	Leaf	R-HSA-1430728	Metabolism
R-HSA-5423646	Aflatoxin activation and detoxification	Leaf	R-HSA-1430728	Metabolism
R-HSA-5579022	Defective GGT1 causes GLUTH	Leaf	R-HSA-1643685	Disease
R-HSA-9035968	Defective GGT1 in aflatoxin detoxification causes GLUTH	Leaf	R-HSA-1643685	Disease
R-HSA-9664535	LTC4-CYSLTR mediated IL4 production	Leaf	R-HSA-1643685	Disease
R-HSA-9753281	Paracetamol ADME	Leaf	R-HSA-9748784	Drug ADME

Location	ECO term	Pubmed
Cell membrane	ECO:0000269	PubMed:23682772
Cell membrane	ECO:0000269	PubMed:8095045

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000020	Urinary incontinence
HP:0000486	Strabismus
HP:0000601	Hypotelorism
HP:0000964	Eczema
HP:0001249	Intellectual disability
HP:0001263	Global developmental delay
HP:0001274	Agenesis of corpus callosum
HP:0001337	Tremor
HP:0001347	Hyperreflexia
HP:0002019	Constipation
HP:0002075	Dysdiadochokinesis
HP:0002099	Asthma
HP:0002282	Gray matter heterotopia
HP:0002345	Action tremor
HP:0003593	Infantile onset
HP:0034445	Reduced gamma-glutamyltransferase level
HP:0034586	Glutathionuria

Tissue	Cell type	Expression level	Reliability
bronchus	respiratory epithelial cells	Low	Supported
colon	glandular cells	Low	Supported
endometrium 2	glandular cells	Low	Supported
epididymis	glandular cells	Medium	Supported
fallopian tube	glandular cells	Low	Supported
kidney	cells in tubules	High	Supported
liver	hepatocytes	Low	Supported
nasopharynx	respiratory epithelial cells	Low	Supported
pancreas	exocrine glandular cells	Low	Supported
stomach 1	glandular cells	High	Supported
stomach 2	glandular cells	High	Supported
urinary bladder	urothelial cells	Medium	Supported