MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1XF7		High Resolution NMR Structure of the Wilms' Tumor Suppressor Protein (WT1) Finger 3
2JP9		Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA
2JPA		Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA
2PRT	3.15	Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA
3HPJ	2.0	Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) peptide
3MYJ	1.89	Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) (R1Y) peptide variant.
4R2E	1.84	Wilms Tumor Protein (WT1) zinc fingers in complex with methylated DNA
4R2P	1.788	Wilms Tumor Protein (WT1) zinc fingers in complex with hydroxymethylated DNA
4R2Q	1.54	Wilms Tumor Protein (WT1) zinc fingers in complex with formylated DNA
4R2R	2.089	Wilms Tumor Protein (WT1) zinc fingers in complex with carboxylated DNA
4R2S	2.489	Wilms Tumor Protein (WT1) Q369P zinc fingers in complex with methylated DNA
4WUU	3.047	Structure of ESK1 in complex with HLA-A*0201/WT1
5KL2	1.692	Wilms Tumor Protein (WT1) ZnF2-4 in complex with DNA
5KL3	1.449	Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with DNA
5KL4	1.783	Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with formylated DNA
5KL5	2.289	Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with carboxylated DNA
5KL6	1.641	Wilms Tumor Protein (WT1) Q369R ZnF2-4 in complex with DNA
5KL7	1.579	Wilms Tumor Protein (WT1) ZnF2-4Q369R in complex with carboxylated DNA
6B0O	1.552	Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet TGT
6B0P	2.077	Zinc finger Domain of WT1(-KTS form) with 12+1mer Oligonucleotide with 3' Triplet GGT
6B0Q	2.794	Zinc finger Domain of WT1(-KTS form) with 13+1mer Oligonucleotide with 3' Triplet TGT
6B0R	1.818	Zinc finger Domain of WT1(-KTS form) with M342R Mutation and 14+1mer Oligonucleotide with 3' Triplet TGG
6BLW	1.835	Zinc finger Domain of WT1(+KTS form) with M342R Mutation and 17+1mer Oligonucleotide with Triplet GGT
6RSY	2.95	The complex between TCR a7b2 and human Class I MHC HLA-A0201-WT1 with the bound RMFPNAPYL peptide.
6WLH		RNA complex of WT1 zinc finger transcription factor
7BBG	2.64	CRYSTAL STRUCTURE OF HLA-A2-WT1-RMF AND FAB 11D06

GO term

GO ontology	GO term	GO description
Biological Process	GO:0008380	RNA splicing
Biological Process	GO:0035802	adrenal cortex formation
Biological Process	GO:0030325	adrenal gland development
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis
Biological Process	GO:0043010	camera-type eye development
Biological Process	GO:0060923	cardiac muscle cell fate commitment
Biological Process	GO:0071320	cellular response to cAMP
Biological Process	GO:0071371	cellular response to gonadotropin stimulus
Biological Process	GO:0060539	diaphragm development
Biological Process	GO:0030855	epithelial cell differentiation
Biological Process	GO:0007281	germ cell development
Biological Process	GO:0032836	glomerular basement membrane development
Biological Process	GO:0032835	glomerulus development
Biological Process	GO:0008406	gonad development
Biological Process	GO:0007507	heart development
Biological Process	GO:0001822	kidney development
Biological Process	GO:0030539	male genitalia development
Biological Process	GO:0008584	male gonad development
Biological Process	GO:0060231	mesenchymal to epithelial transition
Biological Process	GO:0072284	metanephric S-shaped body morphogenesis
Biological Process	GO:0072207	metanephric epithelium development
Biological Process	GO:0072075	metanephric mesenchyme development
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:2000195	negative regulation of female gonad development
Biological Process	GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0017148	negative regulation of translation
Biological Process	GO:0072112	podocyte differentiation
Biological Process	GO:1905643	positive regulation of DNA methylation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0060421	positive regulation of heart growth
Biological Process	GO:2000020	positive regulation of male gonad development
Biological Process	GO:2001076	positive regulation of metanephric ureteric bud development
Biological Process	GO:1902895	positive regulation of miRNA transcription
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0072166	posterior mesonephric tubule development
Biological Process	GO:0006355	regulation of DNA-templated transcription
Biological Process	GO:0003156	regulation of animal organ formation
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0007530	sex determination
Biological Process	GO:0007356	thorax and anterior abdomen determination
Biological Process	GO:0009888	tissue development
Biological Process	GO:0001657	ureteric bud development
Biological Process	GO:0001570	vasculogenesis
Biological Process	GO:0061032	visceral serous pericardium development
Molecular Function	GO:0070742	C2H2 zinc finger domain binding
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0010385	double-stranded methylated DNA binding
Molecular Function	GO:0044729	hemi-methylated DNA-binding
Molecular Function	GO:0043565	sequence-specific DNA binding
Molecular Function	GO:0000976	transcription cis-regulatory region binding
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

InterPro	InterPro name
IPR000976	Wilm's tumour protein, N-terminal
IPR013087	Zinc finger C2H2-type
IPR036236	Zinc finger C2H2 superfamily

Pfam	Pfam name
PF00096	Zinc finger, C2H2 type
PF02165	Wilm's tumour protein

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-9690406	Transcriptional regulation of testis differentiation	Leaf	R-HSA-1266738	Developmental Biology

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000250
Nucleus	ECO:0000269	PubMed:15520190
Nucleus speckle	ECO:0000269	PubMed:15520190
Nucleus, nucleolus
Nucleus, nucleoplasm	ECO:0000269	PubMed:15520190

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0100721	Mediastinal lymphadenopathy
HP:0008187	Absence of secondary sex characteristics
HP:0001643	Patent ductus arteriosus
HP:0100001	Malignant mesothelioma
HP:0001824	Weight loss
HP:0001636	Tetralogy of Fallot
HP:0001195	Single umbilical artery
HP:0000100	Nephrotic syndrome
HP:0012841	Retinal vascular tortuosity
HP:0000813	Bicornuate uterus
HP:0002667	Nephroblastoma
HP:0001541	Ascites
HP:0000837	Increased circulating gonadotropin level
HP:0000044	Hypogonadotropic hypogonadism
HP:0000577	Exotropia
HP:0000939	Osteoporosis
HP:0002017	Nausea and vomiting
HP:0000486	Strabismus
HP:0000142	Abnormal vagina morphology
HP:0000846	Adrenal insufficiency
HP:0007299	Dysfunction of lateral corticospinal tracts
HP:0040030	Chorioretinal hypopigmentation
HP:0000027	Azoospermia
HP:0001680	Coarctation of aorta
HP:0002650	Scoliosis
HP:0000105	Enlarged kidney
HP:0000148	Vaginal atresia
HP:0010923	Anterior subcapsular cataract
HP:0007750	Hypoplasia of the fovea
HP:0002750	Delayed skeletal maturation
HP:0000061	Ambiguous genitalia, female
HP:0000286	Epicanthus
HP:0100779	Urogenital sinus anomaly
HP:0004383	Hypoplastic left heart
HP:0002240	Hepatomegaly
HP:0004322	Short stature
HP:0007759	Opacification of the corneal stroma
HP:0000812	Abnormal internal genitalia
HP:0012244	Abnormal sex determination
HP:0008715	Testicular dysgenesis
HP:0001669	Transposition of the great arteries
HP:0003676	Progressive
HP:0000737	Irritability
HP:0000147	Polycystic ovaries
HP:0008193	Primary gonadal insufficiency
HP:0002089	Pulmonary hypoplasia
HP:0000609	Optic nerve hypoplasia
HP:0001743	Abnormality of the spleen
HP:0001153	Septate vagina
HP:0000776	Congenital diaphragmatic hernia
HP:0000501	Glaucoma
HP:0000028	Cryptorchidism
HP:0012020	Right aortic arch
HP:0010459	True hermaphroditism
HP:0000030	Testicular gonadoblastoma
HP:0000790	Hematuria
HP:0000252	Microcephaly
HP:0010788	Testicular neoplasm
HP:0001522	Death in infancy
HP:0008734	Decreased testicular size
HP:0008232	Elevated circulating follicle stimulating hormone level
HP:0000786	Primary amenorrhea
HP:0003073	Hypoalbuminemia
HP:0040171	Decreased serum testosterone concentration
HP:0002126	Polymicrogyria
HP:0001428	Somatic mutation
HP:0000364	Hearing abnormality
HP:0009112	Aplasia of the left hemidiaphragm
HP:0003819	Death in childhood
HP:0007676	Hypoplasia of the iris
HP:0000518	Cataract
HP:0000006	Autosomal dominant inheritance
HP:0002664	Neoplasm
HP:0003270	Abdominal distention
HP:0002079	Hypoplasia of the corpus callosum
HP:0000822	Hypertension
HP:0001513	Obesity
HP:0003577	Congenital onset
HP:0000058	Abnormal labia morphology
HP:0000047	Hypospadias
HP:0002896	Neoplasm of the liver
HP:0001488	Bilateral ptosis
HP:0000526	Aniridia
HP:0000505	Visual impairment
HP:0011565	Common atrium
HP:0000054	Micropenis
HP:0009918	Ectopia pupillae
HP:0001696	Situs inversus totalis
HP:0000868	Decreased fertility in females
HP:0001647	Bicuspid aortic valve
HP:0001945	Fever
HP:0003774	Stage 5 chronic kidney disease
HP:0008053	Aplasia/Hypoplasia of the iris
HP:0000232	Everted lower lip vermilion
HP:0000969	Edema
HP:0008726	Hypoplasia of the vagina
HP:0000083	Renal insufficiency
HP:0004326	Cachexia
HP:0000823	Delayed puberty
HP:0031883	Increased proinsulin:insulin ratio
HP:0001747	Accessory spleen
HP:0034198	Second trimester onset
HP:0010464	Streak ovary
HP:0012579	Minimal change glomerulonephritis
HP:0008214	Decreased serum estradiol
HP:0002101	Abnormal lung lobation
HP:0002315	Headache
HP:0030010	Hydrometrocolpos
HP:0001967	Diffuse mesangial sclerosis
HP:0000085	Horseshoe kidney
HP:0011720	Cardiac total anomalous pulmonary venous connection
HP:0040314	Blind vagina
HP:0004736	Crossed fused renal ectopia
HP:0011496	Corneal neovascularization
HP:0008665	Clitoral hypertrophy
HP:0005301	Persistent left superior vena cava
HP:0011463	Childhood onset
HP:0008723	Gonadal dysgenesis with female appearance, male
HP:0001952	Glucose intolerance
HP:0100006	Neoplasm of the central nervous system
HP:0000707	Abnormality of the nervous system
HP:0002894	Neoplasm of the pancreas
HP:0011969	Elevated circulating luteinizing hormone level
HP:0003811	Neonatal death
HP:0011947	Respiratory tract infection
HP:0009110	Diaphragmatic eventration
HP:0001629	Ventricular septal defect
HP:0002215	Sparse axillary hair
HP:0012622	Chronic kidney disease
HP:0100242	Sarcoma
HP:0003251	Male infertility
HP:0001650	Aortic valve stenosis
HP:0000093	Proteinuria
HP:0030680	Abnormality of cardiovascular system morphology
HP:0000045	Abnormality of the scrotum
HP:0100615	Ovarian neoplasm
HP:0002595	Ileus
HP:0000771	Gynecomastia
HP:0003762	Uterus didelphys
HP:0002716	Lymphadenopathy
HP:0001903	Anemia
HP:0000037	Male pseudohermaphroditism
HP:0031504	Foamy urine
HP:0100632	Pulmonary sequestration
HP:0000033	Ambiguous genitalia, male
HP:0001710	Conotruncal defect
HP:0000130	Abnormality of the uterus
HP:0025193	Posterolateral diaphragmatic hernia
HP:0008730	Female external genitalia in individual with 46,XY karyotype
HP:0000508	Ptosis
HP:0012870	Vanishing testis
HP:0000149	Ovarian gonadoblastoma
HP:0003248	Gonadal tissue inappropriate for external genitalia or chromosomal sex
HP:0001249	Intellectual disability
HP:0000112	Nephropathy
HP:0002586	Peritonitis
HP:0000260	Wide anterior fontanel
HP:0002027	Abdominal pain
HP:0000639	Nystagmus
HP:0100539	Periorbital edema
HP:0001631	Atrial septal defect
HP:0000133	Gonadal dysgenesis
HP:0100526	Neoplasm of the lung
HP:0033210	Congenital alveolar dysplasia
HP:0011626	Scimitar anomaly
HP:0000815	Hypergonadotropic hypogonadism
HP:0011027	Abnormal fallopian tube morphology
HP:0200020	Corneal erosion
HP:0006703	Aplasia/Hypoplasia of the lungs
HP:0000150	Gonadoblastoma
HP:0000062	Ambiguous genitalia
HP:0001466	Contiguous gene syndrome
HP:0001083	Ectopia lentis
HP:0002225	Sparse pubic hair
HP:0010773	Partial anomalous pulmonary venous return
HP:0002643	Neonatal respiratory distress
HP:0000097	Focal segmental glomerulosclerosis
HP:0033743	Macular agenesis
HP:0100820	Glomerulopathy
HP:0032592	Aplasia of the right hemidiaphragm
HP:0010772	Anomalous pulmonary venous return
HP:0001651	Dextrocardia
HP:0000347	Micrognathia
HP:0002585	Abnormality of the peritoneum
HP:0100627	Displacement of the urethral meatus
HP:0008736	Hypoplasia of penis
HP:0003826	Stillbirth

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Enhanced
breast	glandular cells	Low	Enhanced
breast	myoepithelial cells	High	Enhanced
endometrium	endothelial cells	High	Enhanced
endometrium	lymphocytes	High	Enhanced
endometrium	macrophages	High	Enhanced
endometrium	smooth muscle cells	High	Enhanced
endometrium	stromal fibroblasts	High	Enhanced
endometrium 1	cells in endometrial stroma	High	Enhanced
endometrium 2	cells in endometrial stroma	High	Enhanced
epididymis	glandular cells	Low	Enhanced
fallopian tube	glandular cells	High	Enhanced
kidney	cells in glomeruli	High	Enhanced
kidney	cells in tubules	Low	Enhanced
ovary	ovarian stroma cells	Medium	Enhanced
placenta	decidual cells	Low	Enhanced
placenta	trophoblastic cells	Low	Enhanced
prostate	glandular cells	Low	Enhanced
seminal vesicle	glandular cells	Low	Enhanced
smooth muscle	smooth muscle cells	Medium	Enhanced
soft tissue 2	fibroblasts	Low	Enhanced
spleen	cells in red pulp	Low	Enhanced
testis	sertoli cells	High	Enhanced

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
malignant mesothelioma	MONDO:0006292	C45	chapter2, Neoplasms	OMIM:156240	Orphanet:50251
frasier syndrome	MONDO:0007635	N04	chapter14, Diseases of the genitourinary system	OMIM:136680	Orphanet:347
wilms tumor 1	MONDO:0008679	C64	chapter2, Neoplasms	OMIM:194070
denys-drash syndrome	MONDO:0008682	N04	chapter14, Diseases of the genitourinary system	OMIM:194080	Orphanet:220
nephrotic syndrome, type 4	MONDO:0009733	N04	chapter14, Diseases of the genitourinary system	OMIM:256370
meacham syndrome	MONDO:0012164	Q87	chapter17, Congenital malformations, deformations and chromosomal abnormalities	OMIM:608978	Orphanet:3097
familial idiopathic steroid-resistant nephrotic syndrome	MONDO:0019006	N04	chapter14, Diseases of the genitourinary system		Orphanet:656

Summary of P19544

Gene: WT1
Protein: Wilms tumor protein

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P19544

Gene: WT1 Protein: Wilms tumor protein

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: WT1
Protein: Wilms tumor protein