MultifacetedProtDB - Bologna Biocomputing Group

Catalytic activity

EC number	EC number description
3.1.1.13	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; sterol esterase
3.1.1.3	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; triacylglycerol lipase
3.1.1.6	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; acetylesterase

Publications

PDB	Resolution (Å)	PDB name
1F6W	2.3	STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN BILE SALT ACTIVATED LIPASE
1JMY	2.6	Truncated Recombinant Human Bile Salt Stimulated Lipase
6H0T	1.9	Crystal structure of native recombinant human bile salt activated lipase
6H0V	2.2	Crystal structure of tabun surrogate NEDPA inhibited recombinant human bile salt activated lipase
6H18	1.85	Crystal structure of sarin surrogate NIMP inhibited recombinant human bile salt activated lipase
6H19	1.89	Crystal structure of ethyl-paraoxon inhibited recombinant human bile salt activated lipase (aged form)
6H1A	1.75	Crystal structure of VX surrogate NEMP inhibited recombinant human bile salt activated lipase

GO ontology	GO term	GO description
Biological Process	GO:0046514	ceramide catabolic process
Biological Process	GO:0030299	intestinal cholesterol absorption
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0030157	pancreatic juice secretion
Molecular Function	GO:0008126	acetylesterase activity
Molecular Function	GO:0003824	catalytic activity
Molecular Function	GO:0008201	heparin binding
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0050253	retinyl-palmitate esterase activity
Molecular Function	GO:0004771	sterol esterase activity
Molecular Function	GO:0004806	triglyceride lipase activity
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space

InterPro	InterPro name
IPR002018	Carboxylesterase, type B
IPR019819	Carboxylesterase type B, conserved site
IPR019826	Carboxylesterase type B, active site
IPR029058	Alpha/Beta hydrolase fold
IPR032059	Mucin-like domain

Pfam	Pfam name
PF00135	Carboxylesterase family
PF16058	Mucin-like

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000077	Abnormality of the kidney
HP:0000107	Renal cyst
HP:0000112	Nephropathy
HP:0000119	Abnormality of the genitourinary system
HP:0000488	Retinopathy
HP:0000825	Hyperinsulinemic hypoglycemia
HP:0000831	Insulin-resistant diabetes mellitus
HP:0000956	Acanthosis nigricans
HP:0001511	Intrauterine growth retardation
HP:0001513	Obesity
HP:0001520	Large for gestational age
HP:0001738	Exocrine pancreatic insufficiency
HP:0001952	Glucose intolerance
HP:0001953	Diabetic ketoacidosis
HP:0001998	Neonatal hypoglycemia
HP:0002027	Abdominal pain
HP:0002594	Pancreatic hypoplasia
HP:0003074	Hyperglycemia
HP:0003076	Glycosuria
HP:0004904	Maturity-onset diabetes of the young
HP:0004924	Abnormal oral glucose tolerance
HP:0008255	Transient neonatal diabetes mellitus
HP:0011462	Young adult onset
HP:0012028	Hepatocellular adenoma
HP:0025502	Overweight
HP:0030057	Autoimmune antibody positivity
HP:0030794	Abnormal circulating C-peptide concentration
HP:0040214	Abnormal circulating insulin concentration
HP:0040216	Hypoinsulinemia
HP:0040217	Elevated hemoglobin A1c

Tissue	Cell type	Expression level	Reliability
lactating breast	lactating glandular cells	Medium	Enhanced
pancreas	exocrine glandular cells	High	Enhanced
stomach 2	glandular cells	Medium	Enhanced